How are people with liver mets doing?

Dear BAP, sorry to answer late - time difference. When you guys sleep, I work and live, when I sleep, you work and live, ehh... I am very sorry for what you go through. "Not fair" are not the words that can describe the whole situation. You are strong and known for coming back out of dark places. Once you will be better on Ibrance, many other options will open up. Definitely your son deserves to have mom and dad on Christmas morning. And he will. Not only this year but the next one too. You are a wonderful mom and should be proud of yourself. One day or day one - we decide. What a wonderful community here. Lot's of hugs to everyone,

Saulius

AlabamaDee's account continues to be compromised. The poster above, AlabamaDeee, which started out as BamaD is NOT the real AlabamaDee. We are in contact with the real AlabamaDee and she has NOT re-registered. Please do not respond to anyone claiming to be AlabamaDee until we notify you.

Please be cautious about sharing your email addresses, or any personal information over PM.

We are working on this issue. Please contact us via PM, or to community@breastcancer.org if you have any concerns.

Warmly,

The Mods

BAP, so sorry you’re having trouble with treatments. I also wondered about Verzenio as I couldn’t tolerate Ibrance. My hemoglobin tanked completely. Sending a virtual hug!

Amazing with Dee. I can’t fathom why anyone would want to compromise an account on BCO…

BAP, it seems like you have a plan. I can understand where you are coming from as my marrow is clearly going to be an issue going forward. I had good success with Xeloda but my MO wanted me to pause as my RBCs were out of whack on that treatment as well. Now, on Vinorelbine, I can see my RBCs are starting to drop, taking my hemoglobin along for the ride. Bit worried that there will be hesitancy to switch to something else immediately if this treatment is not working… Probably getting ahead of myself but my woosy blood has proven to be pretty annoying!

Hi Susan,

I think I mentioned in an earlier post that it was always tricky to figure out progression with me until it hit my liver. The pleura is hard to measure, bone scans were useless and all my bone lesions are sclerotic. As a result, while at the time my scans said stable, I was having symptoms that made me doubt this so we moved on to Faslodex which gave me a good long run. When the liver mets showed up I suggested we try Xeloda again and, thankfully, it worked

Nicole- I had to switch after a single liver tumor showed up and all wise was stable. I had a liver reduction surgery and took it out. Changed to taxol. Was told xeloda had failed me. Taxol worked great until my brain stopped behaving. I had to switch again to control it. I do know people who have made and argument for staying on current treatment if all is good elsewhere.

Good luc

Nicole, In clinical trials they standardized this stuff & they use RECIST criteria to determine what counts as stable and what counts as progression. They measure and add up the sizes of the lesions and add it all. So if one is shrinking a lot but another is growing, if you add it up the change might actually be 0 and then it would not count as progression.

BUT, my oncologist also said it's a trickier thing if it's happening in the same organ because it likely means the cancer is heterogenous and if there's no chance of a local therapy then what is the point of waiting? If one lesion has developed resistance and keeps growing, it will hurt the organ and that's bad news. If you switch systemic tx, the hope is that both the resistant lesion & the other lesions will respond to the new treatment...

Thanks for the tip, Moveforward. I have dry mouth all day long. Biotin never helped me either.

I'm I'm hospital severe pain in brain. Did a CT scan they saw somethjng..looks like a brain met.....waiting for MRi all I know is is its on the right in the Front??? FINDINGS: There is an ill-defined area of hypodensity in the subcortical

white matter of the right frontal lobe, best identified on images

#14-16. It measures approximately 1.8 cm in size. There is no mass

effect.

I'm freaking out

Oh Nicole, that is terrible. We are with you. We never get tired of giving out hugs and support here.

Nicole, what a scary development. But wait for the MRI to get better info. If it is a brain met, there are good treatments. Think of Illimae. I'm sorry this is happening!

{{{ Oh sweetie, I'm so sorry and will be thinking of you.}}}

I am probably going to be checking nyself out if hospital before MRI....its a nightmare in here I'm still waiting I would rather just get it out in town . The Neurosurgeon fellow came down and basically ci firmedbits a met its not a white area its a gray black lesion etc. The MRI is just ci firm and get more details. So my question is....obviously my treatment fauled..but no treatment oenetratrs blood brain barrier so what does that mean for brain metzers as far as systemic therapy??

It's not correct that systemic treatment drugs don't cross the blood / brain barrier. I've forgotten which one's do, but some do.

I believe they often treat brain mets with radiation, and it's quite effective.

Nicole, I'm so sorry this is happening but as others have said, please wait for the MRI to get as much information as possible. It can be treated. Sending hugs.