Kisqali/ribociclib, Faslodex/fluvestrant & Xgeva combo - Anyone?

tangandchris - your experience with your first faslodex shot reminded me of mine. It was the week I received the new diagnosis, and in order to get the faslodex injections, I had to go to the same infusion center where I had received chemo and rung that bell three years earlier. I was shaking and in tears. I was taken by such surprise by how being back there affected me. The poor nurse offered to wait, but I just wanted to get out of there.

Anyway, the injections I've had since then haven't been terrible. It was just the shock of everything. I hope things have gone better for your since.

Hello All,

New to this page. My name is Jane and I was dx'd with MBC about 6 weeks ago. I am on Faslodex and Kisqali.

I'm only at end of my second week of first cycle of Kisqali and side effects have not been too bad so far. Some nausea but not terrible, right after I take it (I've been taking in eve after dinner). The nausea passes in about 20 mins or so. I was definitely interested in hearing others report that fatigue can build once into the third week, so we'll see how that goes. I'm def very tired early in the evening but I've never been a night owl anyway, lol. I was at the beach this week and my skin is definitely more prone to burning now and I also got some skin rash after being in the sun. Shade it will be for me from now on!

The Faslodex butt pain has been a bit of a problem so I will def try that massaging and walking right after the injections that was recommended - thank you. It's been super hot here in NJ so the hot flashes have not been fun!

All this being said, I'm finding the se's manageable so far. But of course it's all still new to me!

Looking forward to sharing and learning together.

Jane

Hi NCYogi-

I didn't even know there was a profile to fill out lol so will do so now. Glad to connect with you and others here!

Jane

Hi all,

Thanks for checking in NCYogi. I'm literally just about to take my last dose of Kisqali for this first 21 day cycle. Feeling well overall - just tired by around 6 pm (now lol) and still some skin rash. My MO told me I could take an over the counter antihistamine for the rash and that seems to be helping. Hope Kisqali goes smoothly for you - overall I can't really complain about it!

Jane

Hi Beth! I’m on my 3rd cycle but haven’t had scans yet so I’m not sure about effectiveness (yet). I can tell you that my breast tumor (large!) has shrunk a lot because I can barely feel it & it WAS big & hard. My SE have been minimal so far. I’ll let you know after my scan. Fingers crossed for all of us

I've been on this combo about six months. At my first set of scans, the mets on my liver had reduced by 50%. No change to the tumor in my armpit. I've got my next set of scans in about two weeks. I have not had bad side effects except in the last month or so I've started getting joint pain from the faslodex. My family took a trip to Disneyworld earlier this month and by the third day I had to rent a scooter because the pain from walking all day was keeping me from enjoying the trip. I felt bad about that, but the scooter really helped. I generally take my meds at night with a protein shake, then follow them up with a dose of medical THC (cannabis tincture). The THC helps me sleep and reduces nausea.

I'm also on a whole stack of supplements prescribed by a integrative medicine doctor with a background in oncology. I think they help with the side effects. I only really started noticing the joint pain when I let some of the more expensive supplements run out.

Hi again, I take my pills with dinner to avoid nausea. I’m not sleeping great but I blame that on my sudden menopause (oopherectomy) & faslodex. 🤷🏻♀️ Hot flashes wake me up nightly. I’m going to try acupuncture & see if that helps. What cannibis do you use? Thc is illegal in NC & I haven’t investigated the medicinal route yet. Any advice is welcome!

I'm currently on this regimen. I'm on Xgeva as of 3 months ago, added late. I was searching for Xgeva info, but I'm not seeing much here.

I had my 3rd shot today and by the time I got home I felt completely wiped out. Surprisingly because I didn't notice this the other 2 times.

Do yall notice Xgeva adding fatigue? Of course I was told this drug has minimal se's lol. Don't they always say this?