All about Xeloda

Denny,

I am Her2- and on xeloda, but I do have two ERBB2 mutations -- so I'm not positive, but I have these somatic mutations. Just something to think about. Will you have a biopsy to determine status?

Denny,

You should do what you feel comfortable with. Clearly, you've had much success in managing this disease. But I've got to think that biopsy techniques have improved in 19 years. I've had two liver biopsies in the past two years and they were fairly easy (I know it could have to do with location of the tumor.) Just keep this is the back of your mind. And good luck. I hope the dosage increase helps with stabilization.

Bev

Bev...thanks for your input! The first biopsy hit my lung...the second missed the spot but was in my liver.

The location was the problem so the third one was done from my left side...through my abdomen clear to my liver on the right side. Each poke was like child birth times 100. It took 2 hours of poking and I ended up with internal bleeding.

And I had to have a liver resection of sections 7&8, so that area is gone now.

This new spot is at a different place...the left hepatic lobe. And there is another spot visible on the right hepatic lobe, but non-specific.

In 2004, my liver was so filled ith mets that I only had a year to live. I don't want to go through that stress again.

Denny- you and I sound very similar but you have more years than I. I was unable to biopsy my chest node and the repeat scan showed it was still there but bother/masked by all my pneumonitis. Wondering if it iHer2 - but will never know. Next scan in early OCT.

I’m in kadcyla with tucatinib for my current cancerZ mostly to keep brain Mets at bay. Not a lot of wiggle room due to brain Mets. Oncologist said I failed xeloda since I had one liver Mets develop in 2015. guess I wait and see

Thanks ladies!

Leftfoot...my 2 chest nodes could not be biopsied since they were behind my sternum. So they did a boodwork test for Foundation One and that showed that I had changed to Her2-.

I'm sure this has been discussed before, but have any of you had hair loss after being on xeloda for a while? I've been on xeloda (very low dose) since July and have noticed a few stray hair here and there. But this morning when I brushed my hair, quite a bit came out. I'm not sure if it's the xeloda or the neratinib or the combo that's causing it. Also having been eating great on the xeloda and wondering if that could be affecting the hair issue.

BevJen, I had quite a bit of hair thinning in the early days but it seems to have settled down now. I’m still losing hair but I’m also growing new hair at about the same rate……….everywhere except the nether regions anyway

BevJen, my hair is growing back on Madame X. I even get a haircut and have dyed it again. I also have to shave my legs again...something I hadn't had to do for several years.

BevJen...my hair thinned at first, but is okay now. It has always been thin and fine and 19+ years on chemo haven't helped.

I get about 5 hairs per leg.

Denny, If my hands and feet aren't buzzing, or numb, I'm wondering if Xeloda is working- so the SE is a reminder that it is working. I went from 3000 14/7 down to 2500 14/7 and now I'm going 5 days on, 2 days off, then 7/7 on 2500. It's better than going all the way down to 2000 a day and the Side Effects are less now with a break in the middle. Hope the increase works for you if you try it.

Hope you do well and hopefully it works!

Perhaps use Udderly during the day when you are working.

I am retired and on my computer all day since I have online stores. So when I am just typing, Aquaphor is okay. And it eventually sinks in.

When I have to handle something like fabric or paper, I wait for a bit until it sinks in.

Socks and gloves at night do soak up the Aquaphor so I use silicone socks and food service gloves.

Yay, Mis!!

Excellent news Mis,so happy for you!

Yay Mls!!!!