Any scientists or pharmacists out there?

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chocomousse
chocomousse Member Posts: 157
edited October 2021 in Complementary and Holistic Medicine and Treatment

Could someone tell me what 300 mM MSM translates into in terms of milligrams, per the article below?

The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

MSM is a natural sulfur containing compound which acts against various breast cancers [10, 27, 28] and is already found as an efficient drug in combination therapy against cancer cells [46]. Combination therapy is one of the methods we can employ to reduce the adverse effects of the drug, either by reducing the concentration of the individual drug, or by synergising the mechanism of the drug. The dosage of MSM we used in this study is a higher concentration. It is not the amount of MSM that contains in food. We used a concentration of 300 mM MSM (individual concentration) just for pharmacological purpose. In order to check the efficacy of combination therapy, we reduced the concentrations of both MSM (200 mM) and Tam (15 μM). Treatment with Tam may cause joint pain to the pateients, whereas MSM is an effective drug for the treatment of joint pain. So the usage of this drug combination may also reduce the joint pain caused by Tam.

https://bmccancer.biomedcentral.com/articles/10.11...

TIA.

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  • AMG2
    AMG2 Member Posts: 130
    edited August 2021

    I'm coming up with 28.24 g per liter.

    300 mM is 300 milimoles per liter. Converting that to molar, there are 1000 mmoles per mole, so 0.3 moles per liter. The molecular weight of MSM is 94.13g per mole,

    0.3 mol/L x 94.13 g/mole = 28.24 g per L

    Hope that is what you were after, and that my math is right.

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  • Esther01
    Esther01 Member Posts: 294
    edited August 2021

    Wow AMG2, that's amazing! I knew it was mM was moles, but that's it!

    Chocomousse, my paltry contribution is that you can ask my doctor who is also a biochemist about MSM to see if she's seen it used in combination with Tam. She treats thousands of cancer patients and gives a free "Ask the Doctor" Q&A on Mondays on Youtube as a gift from her medical practice. PM me if you'd like the link.

    Blessings,

    Esther

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  • AMG2
    AMG2 Member Posts: 130
    edited August 2021

    Actually, in reading the methods, I'm a little confused, because they state their dosage 2 different ways. One is 300mM in a 100 uL (0.1 ml) injection, and the other was also a 0.1 ml injection of a 3 percent solution of MSM (I think this would be 3 g per 100 ml). Anyway, it's a little ambiguous. The first one could mean that they made a 300 mmol solution of MSM and used 0.1 ml of that solution per mouse. This would actually make a lot more sense because 28 g of almost anything would not likely dissolve in 100 microliters.

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  • chocomousse
    chocomousse Member Posts: 157
    edited October 2021

    Thanks so much for responding AMG2. How much does 28.24 g per L translate into in terms of a daily oral dosage in grams or mg?

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  • chocomousse
    chocomousse Member Posts: 157
    edited August 2021

    Thank you Esther01! ❤


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  • chocomousse
    chocomousse Member Posts: 157
    edited October 2021

    Bumping.

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