Heart problems with Herceptin & Perjeta
Hi everyone. I recently had a significant change in left ventricular function on my echocardiogram. Holding this months dose of HP. Wondering if others experienced this? Did it improve by holding a dose? If had to stop permanently, did you receive some other treatment going forward. I have 5 more HP treatments to completion. Concerned because HER2+, HR/PR Negative. IBC . MO resistant to any kind of imaging surveillance. Any bio markers that your MO are following for those that havecompleted TX. ?
Comments
-
My ejection fraction went down to 42 during her Herceptin treatments (no perjeta, I believe it was in the study phase) and we continued. I received no echo’s for the rest of my chemo treatments. My initial ejection fraction was in the low normal range- 58 to 62.
-
Yikes Kathleen! Did you have any echo after completion? And did the EF recover? Any long-lasting side effects experienced?
-
I did not receive a final echo, or an echo since and I am in my 11th year of remission. I have had no serious health issues in the last 11 years. I do have side effects from treatment. Lymphedema, brain fog that never really went away and fatigue.
-
I haven’t had heart issues, but my MO told me that the solution for herceptin heart issues was stopping the herceptin, and then it would improve. Hopefully holding a dose will help as well and you will be able to continue.
I also wanted to share that there was a study that showed 6 months of herceptin could be as good as a year. Obviously being able to finish the treatment since that is the standard would be nice — but stopping early might not be the worst thing either.
https://www.breastcancer.org/research-news/herceptin-for-6-months-seems-same-as-1-yr -
melbo: thanks for the info. The heart function is unchanged after 6 weeks off of Herceptin. All remaining treatments are canceled, at least until cardio-oncologist evaluation. Unfortunately, he is in high demand & since I am asymptomatic earliest appointment is in October.
On the bright side, I only had 3 more treatments remaining according to my MO, I had a fantastic response to adjuvant therapy,
We discussed Neratinib which is FDA approved after Herceptin, but, no studies yet on efficacy if Perjeta was also received, so she will not prescribe it.
I am in surveillance phase officially! Just in the nick of time, it seems because my husband is undergoing testing for Lymphoma. All focus and support needs to be on him! He was my Rock of support. Now I will be his.
Categories
- All Categories
- 679 Advocacy and Fund-Raising
- 289 Advocacy
- 68 I've Donated to Breastcancer.org in honor of....
- Test
- 322 Walks, Runs and Fundraising Events for Breastcancer.org
- 5.6K Community Connections
- 282 Middle Age 40-60(ish) Years Old With Breast Cancer
- 53 Australians and New Zealanders Affected by Breast Cancer
- 208 Black Women or Men With Breast Cancer
- 684 Canadians Affected by Breast Cancer
- 1.5K Caring for Someone with Breast cancer
- 455 Caring for Someone with Stage IV or Mets
- 260 High Risk of Recurrence or Second Breast Cancer
- 22 International, Non-English Speakers With Breast Cancer
- 16 Latinas/Hispanics With Breast Cancer
- 189 LGBTQA+ With Breast Cancer
- 152 May Their Memory Live On
- 85 Member Matchup & Virtual Support Meetups
- 375 Members by Location
- 291 Older Than 60 Years Old With Breast Cancer
- 177 Singles With Breast Cancer
- 869 Young With Breast Cancer
- 50.4K Connecting With Others Who Have a Similar Diagnosis
- 204 Breast Cancer with Another Diagnosis or Comorbidity
- 4K DCIS (Ductal Carcinoma In Situ)
- 79 DCIS plus HER2-positive Microinvasion
- 529 Genetic Testing
- 2.2K HER2+ (Positive) Breast Cancer
- 1.5K IBC (Inflammatory Breast Cancer)
- 3.4K IDC (Invasive Ductal Carcinoma)
- 1.5K ILC (Invasive Lobular Carcinoma)
- 999 Just Diagnosed With a Recurrence or Metastasis
- 652 LCIS (Lobular Carcinoma In Situ)
- 193 Less Common Types of Breast Cancer
- 252 Male Breast Cancer
- 86 Mixed Type Breast Cancer
- 3.1K Not Diagnosed With a Recurrence or Metastases but Concerned
- 189 Palliative Therapy/Hospice Care
- 488 Second or Third Breast Cancer
- 1.2K Stage I Breast Cancer
- 313 Stage II Breast Cancer
- 3.8K Stage III Breast Cancer
- 2.5K Triple-Negative Breast Cancer
- 13.1K Day-to-Day Matters
- 132 All things COVID-19 or coronavirus
- 87 BCO Free-Cycle: Give or Trade Items Related to Breast Cancer
- 5.9K Clinical Trials, Research News, Podcasts, and Study Results
- 86 Coping with Holidays, Special Days and Anniversaries
- 828 Employment, Insurance, and Other Financial Issues
- 101 Family and Family Planning Matters
- Family Issues for Those Who Have Breast Cancer
- 26 Furry friends
- 1.8K Humor and Games
- 1.6K Mental Health: Because Cancer Doesn't Just Affect Your Breasts
- 706 Recipe Swap for Healthy Living
- 704 Recommend Your Resources
- 171 Sex & Relationship Matters
- 9 The Political Corner
- 874 Working on Your Fitness
- 4.5K Moving On & Finding Inspiration After Breast Cancer
- 394 Bonded by Breast Cancer
- 3.1K Life After Breast Cancer
- 806 Prayers and Spiritual Support
- 285 Who or What Inspires You?
- 28.7K Not Diagnosed But Concerned
- 1K Benign Breast Conditions
- 2.3K High Risk for Breast Cancer
- 18K Not Diagnosed But Worried
- 7.4K Waiting for Test Results
- 603 Site News and Announcements
- 560 Comments, Suggestions, Feature Requests
- 39 Mod Announcements, Breastcancer.org News, Blog Entries, Podcasts
- 4 Survey, Interview and Participant Requests: Need your Help!
- 61.9K Tests, Treatments & Side Effects
- 586 Alternative Medicine
- 255 Bone Health and Bone Loss
- 11.4K Breast Reconstruction
- 7.9K Chemotherapy - Before, During, and After
- 2.7K Complementary and Holistic Medicine and Treatment
- 775 Diagnosed and Waiting for Test Results
- 7.8K Hormonal Therapy - Before, During, and After
- 50 Immunotherapy - Before, During, and After
- 7.4K Just Diagnosed
- 1.4K Living Without Reconstruction After a Mastectomy
- 5.2K Lymphedema
- 3.6K Managing Side Effects of Breast Cancer and Its Treatment
- 591 Pain
- 3.9K Radiation Therapy - Before, During, and After
- 8.4K Surgery - Before, During, and After
- 109 Welcome to Breastcancer.org
- 98 Acknowledging and honoring our Community
- 11 Info & Resources for New Patients & Members From the Team