Mom's breast cancer is her2 positive (per 2018 guidelines )

Jcextra123
Jcextra123 Member Posts: 11
edited July 2021 in HER2+ (Positive) Breast Cancer

So we found out that mom's breast cancer is her2 positive per 2018 guidelines. She has an her/cp ratio of 1.5 (FISH) which would make it her2 negative and an her2 4.4 immunochemistry which is considered positive. But she has as a ki67 of only 7 percent. And no lymphovascular invasion. Could she still be her2 negative overall? When they go in and do the surgery tommorrow and see that it hasn't spread to any lymph nodes could she do just surgery and hormonal therapies and skip radiation and chemo. She is 67 years old. I've read there was a similar benefit to women 70 and older with no lymph node involvement. Where they could skip radiation and chemo and just do the hormo me targeted treatment and surgery whether lumpectomy or masectomy


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  • Redkitty815
    Redkitty815 Member Posts: 44
    edited July 2021

    My mom was diagnosed with Her2+/ER+/PR- cancer in March. She had a 6 mm tumor, grade 3, node negative. We received 3 different recommended treatment plans because of her age (75), existing conditions (Parkinson’s) and the small size and early stage of the tumor. The options were Herceptin + Taxol (the gentler of the taxanes), Herceptin + taxotere, and no chemo, just radiation and hormone therapy. So it’s possible, but for anything larger than a 5 mm tumor, the guidelines recommend herceptin + a chemo. We ultimately decided to go with Herceptin + taxol with a low bar to stop the Taxol should my mom have any neuropathy which could further complicate her Parkinson’s.

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