How are people with liver mets doing?

NicoleRod, SadiesServant..thank you.

I feel like I am being pulled in two directions and I don't have the luxury of time for 2nd opinion..mets growing fast.

I will do the mapping to see IR still thinks I am a good candidate. He said it is not the size of lesion, it is the volume of disease in liver that he would not do y90. The more we wait, the less opportunity to use Y90. He is contacting my MO.

ahh sandi that is so hard. is there any way you could get a taxane infusion and do y90 right before your next infusion? or do it somewhat in between infusions? that is what i am trying to do for my mom but with doxil and MO agreed. meeting with IR in a week so we'll see

LFF, maybe that is good that those markers have never been a good indicatot.

You need a mini vacation. Can that happen? Just to get away. Between work, your kids, graduations..whew.

I am glad you are being watched, esp with potentially moving up the scan. You have not had a rest from this..you have to be mentally and physically exhausted.

welcome mia_milion

As you can see this board is very busy. Ibrance (cdk 4/6 drug) plus an AI is a recommended first line metastatic treatment. Often there is great response for a long period but sometimes not.

I started with Verzenio and Faslodex. It did not work for me. So they tried chemo next for me. I hope you can find the next systemic treatment that works well for you.

Please consider local liver treatment and talk to a IR( interventional radiologist) for y-90 and other ablations AND/OR talk to a Radiation oncologist about SBRT (high dose targeted radiation) these procedures have helped me to whack-a-mole the tumors until I found a systemic treatment that worked.

Let us know how it goes for you. We care.

Dee

Cyber HUGS to all of you suffering. 🥰

Long time lurker and finally joining the conversation. I've run through most of what's still on the treatment menu and currently holding steady with some liver improvement with 3 weeks on one week off taxol. Bone Mets galore but only slight progression over the years. Tired, cranky, feet like bricks. Fuzzy cotton head. Oh, forgot to mention SBRT in signature. Everything works for awhile. The latest kicker is my Covid antibody test came back negative. Here I was feeling my Cheerios only to find out that the vaccine gave me absolutely no immunity.

Enough about me. I've been following you all and hope we can all hang on as we live with all the pain, uncertainty,and ups and downs. Here's to finding ways to rebound and live as well as we can for as long as we can

Can someone clearly define what is meant by "diffuse" liver mets?

I should know..but do not.

Nicole and Sandi, thanks for your welcome words. The posts on this thread gave me the comfort level to participate.

Nicole, you continue to be a trooper. I have admired your concern for others at the same time you have been dealing with almost constant pain.

Sandi, if you do begin Taxol, it started working for me right away and made the side effects more doable since I knew it was worth it. You actually have around two energetic days before the premed steroid wears off. Downside is the trade off of staying awake most of the night. A really good book helps until you finally nod off. Taxol side effects are very predictable for almost everyone. There used to be a thread about taxol for mets. It has been inactive for awhile but very informative and encouraging.

Shared experiences are so helpful. Only fellow travelers on this path can truly understand.

I really appreciate you pointing me to this information. After reading the FDA's current thinking, I am far less “down in the dumps" about my negative antibody test. I will continue to take regular precautions and wear a mask when appropriate. You made my day

Dear MCbookair2018, what do you oncologists say? I never say "this is the end" - there's always something that can be done, in my humble opinion:/

Dear Bliss, how have you been, what is your situation?

Hugs to everyone,

Saulius

Nicolerod. I stay low with most chemo but with this one, Navelbine, it’s just gotten lower and lower each TX. My other values were lower too. My bone marrow is definitely having a lot of trouble keeping up. I thought cut off for transfusion was HGB was 7 but she said 8. I’m sure she’s looking at other symptoms too. Like rapid HR, dizziness etc.

So I had my one unit of blood yesterday. It does feel like I have more energy and my brain is working better this morning. It needs to. I have a busy week. Chemo on Thursday. Neupogen shots on Friday Saturday and Sunday. I asked about Neulasta patches. Nope not on this drug because of it being 3 on one off cycle.

Got my scans scheduled for off week but I won’t know results until July 8

SandiBeach57: My wife has both discrete tumors and diffuse mets in her liver. Diffuse means the cancer is spread out, or "peppered" through the tissue, as opposed to being in defined tumors. On a scan it can look like cirrhosis.

Macbookair2: If you suspect ascites, take her somewhere they can use ultrasound to diagnose it. Forget about the tap tap on the belly method. It is often inaccurate. Aside from an MRI, ultrasound is the most accurate and convenient way to spot fluid. X-ray, no. The can do a paracentesis, where they insert a needle in a singe spot and drain a lot of it. If it continues, a tube can be inserted so you can drain it at home (with a little training). Diuretics can help slow the accumulation. There are two they use in tandem to help cancel out side effects. Also, if blood clots are causing hepatic hypertension, a heparin based blood thinner can be used to reduce the formation of new clots. When they do a draining, they can analyse the fluid to determine whether there are cancer cells in the fluid or not. That gives them some information about the nature of the ascites. If the ascites is caused by hepatic hypertension, they need to watch out for varices that can form and bleed in the esophagus and other area where the blood backs up.

CONGRATS ALABAMADEE !!!!!! Always good to read good news.

Wow Dee! Is this the CK2/4/6 trial with your ESRI mutation?

Nicole,

Have you been on Trodelvy (Sacituzumab Govitecan)? My MO has been giving it to a lot of her patients and every single one has responded.

I know you didn't want to debate but you still have other treatment options including clinical trials.

I care a lot about you even though we have never met in person. If you ever want to talk, send me a PM and I'll give you my phone number.

Big hugs, Susan