Anyone have high Ki67 and low RS?
Hello,
I just had my double mast and am awaiting Oncotype results. All tumors biopsied (3) showed Ki67 was >20 and I am trying to get prepared for a RS that says chemo will be needed. But I keep reading conflicting studies on the matter and I know more than just Ki goes into achieving the RS. Just curious what others have experienced?
Thanks!
Comments
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hi lovenow. My ki67 was 24%. Yes, ki factors in to the equation but my neg PR status was the biggest contributing factor to driving my score up. My oncotype was 27 and I did do chemo. The tailor x study results were not out yet at that time but it confirmed it was the right decision in my case. Others will chime in but most of the time oncotype and ki results tend to be in the same ballpark. Wishing you the best and sending wishes a speedy recovery from surgery
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Hi; sorry; but not me. My KI-67 was 30; and my oncotype even higher. I had chemo (Taxotere and Cytoxan). Finished those in December 2019.
For what it’s worth; I was shocked when my MO advised me toward chemo. Shocked .... I took 3 days to “think about it.” (Yes, really..), then I said “sign me up now.” Everyone is different, but for me, my imagination of what chemo would be like and the reality were much different. It was hard, but entirely doable. I had few side effects, and those were manageable.
Good luck to you!
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My ki67 was 59% and my oncologist did think that was going to translate to a high onco and chemo despite my ER and PR being at 90 to 100%. My oncotype score was 15 so no chemo. I know the stress of waiting for that test to come back and was trying to prepare myself for it.
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agree Sarah. I understand your delay in response. With early stage its hard to accept chemo is on the table. The PR neg seems to be the biggest contributed to a higher oncotype. Not fun but doable
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my Ki-67% was 60, my Er was over 90% my Pr was over 90% my oncotype result was 31. Last time I talked to my onc. She said she would have recommended chemo for me regardless of my ki-67 because I am a BRCA 2 mutant and some studies indicate that BRCA mutated cells may be more vulnerable to chemo b/c they are already deficient. Sucks but at the same time with having the BRCA and the Grade 3 tumor etc etc I'm glad I got 'the full works' chemo/rads/removal of ovaries and tubes and now letrozole.
My suggestion is while you are waiting assume they are going to tell you they recommend chemo and do your research while you wait on chemo and make a plan on how you will manage having chemo (daily life/work/etc) and then if it turns out it's not recommended--bonus and if it is recommended you've already started getting yourself prepared.
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Thanks to everyone for your replies!
2019whatayear, I am also BRCA2 positive and had never heard that this can influence as well. good to know!
My head is spinning from so many variables. Just got off the phone with Radiation Oncologist who says I'm riding the line between treatment or not as one tumor was 5.1cm but grade 2 and the other breast had at least two smaller tumors and one was grade 3. All nodes were negative. Sounds like RS is going to be most important factor in what comes next anyway.
Happy to hear your treatment was manageable Sarah, gives me hope if I need to go that direction.
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Hello, fellow mutant! Chemo sucks but it is doable. Because of the BRCA2 my MO has taken to managing me as high risk from our first meeting. I like and dislike the surveillance--I mean I like knowing I have done everything I can do to reduce my RS as much as possible but also I stress now that I'm out of active treatment.
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my KI67 was 40, and my oncotype was 16.
I opted for chemo.
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Hi LoveNow,
My Ki67 was 52% (but with a mitotic score of 1) My oncotype score was 8. I've wondered if the Ki67 score was inaccurate. I didn't have chemo. I was 60 at the time of diagnosis. (FWIW, my grade went from 2 for the biopsy to 1 after my mastectomy.
Good luck!
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OnTarget what did you base your chemo decision on since your oncotype score was relatively low?
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My ki67% was 20, I had grade 3, but my Oncotype was 8. I read that the ki67% is not always accurate and some docs don't use it. I also wondered if proliferation was higher from the biopsy healing at that site.
The ki67% is just one of a few proliferative factors in the Oncotype test. I forget, maybe three total?
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LoveNow,
My oncotype was considered intermediate. Per the 2019 TAILORx results, people with high risk characteristics (tumor size, etc), who are under 50 years old, and who have intermediate oncotype results, have a higher distant recurrence risk and a greater chemo benefit than the larger group. My distant recurrence risk was 12-13%, and my chemo benefit was 6% I think. That was enough of a benefit for me to feel it was worth it.
Thanks!
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My Ki-67 was 20, which is considered high I believe, but my Oncotype score was only 7.
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