Does tamoxifen interfere with Wellbutrin working?

orangeflower,

My non-doctor understanding is that the answer is no. Wellbutrin messes with tamoxifen because it is an inhibitor of the CYP2D6 liver enzyme, which is needed to metabolize tamoxifen. Wellbutrin itself is metabolized by the CYP2B6 liver enzyme, and I don't see anything anywhere saying that tamoxifen is an inhibitor of CYP2B6. Here's some more info on Wellbutrin metabolism and interactions: https://www.drugs.com/pro/wellbutrin.html#s-34073-7 (scroll down to the "drug interactions" section).

Wellbutrin interferes with how Tamoxifen attaches to receptors. There are a lot of articles / case studies that recommend other antidepressants that are in a different class.

If you go the the link in the other post and type in Tamoxifen and the look up Wellbutrin, there is an explanation in plain English and you can also read the professional info - that goes into more detail about percentage of cancer reoccurrence when using antidepressants are moderate to potent inhibitors versus ones that are mild inhibitors.

I have been doing a lot of reading about this because I have not had success with other antidepressants and I didn't want to switch.

If the oncologist and the psychiatrist don't know, the person to ask is a good pharmacist. Maybe your cancer center has one. Your doctors should have offered to speak to one on your behalf, but maybe you would rather speak directly to the pharmacist anyway.