Aromotase Inhibitors and Restless Legs

Butterfly, is not a common side effect of Arimidex but some women may have difficulty sleeping while taking this treatment. Make sure to ask your doctor about this and review your current medications with him/her to see if any might be contributing to sleep issues.

Best,

The Mods

Magnesium helped my when I was pregnant and had few times restless leg syndrome. Let us know if it works for you.

I have had restless legs for the last 25 years. I don’t think it’s letrozole. Try limiting coffee, sugar and salt intake. I find that this helps most of the time. There are times where I want to chop my legs off from the pain being so intense that it affects my entire being

I don't have restless legs, but intractable leg cramps frequently wake me up at midnight, 1:30, 3, 4:30, when I leap from the bed like a maniac and hop around in agony. I've tried drinking plenty of water, potassium, calcium, magnesium, soap under the sheet, pickle juice, hot water, compression stockings, Ben Gay, stretching, not stretching. Nothing helps when it's a cramp kind of night. It's like my lower legs have snakes crawling around under the skin until the twitching coalesces into massive cramps that leave my muscles sore for days. At 5:00 AM it's hopeless so I usually just stay up and resign myself to a zombie day.

Cramp nights seem to come in waves, like a month at a time, then a cycle of better nights. I've thought perhaps it's the Letrozole, but I've been on it since 2012 and haven't suffered cramps all this time. Maybe it's just the passing of years. It sure sucks.

I’ve had RLS for many years. Klonopin (Requip, etc) are no longer used as they make it worse by causing augmentation. Gabapentin and similarly, Lyrica (pregabalin) are most commonly prescribed now. Make sure your iron levels are okay. That usually needs to be dealt with first.