Choice of anesthesia may change metastatic process of breast cancer

Jun Lin, MD, PhD, of the Department of Anesthesiology in the Renaissance School of Medicine at Stony Brook University, and colleagues found that sevoflurane anesthesia leads to more metastatic burden in the lung after breast tumor resecting surgery than propofol in laboratory models.

The study findings may serve as a guide to design clinical trials for clinicians to optimize anesthesia choice for breast cancer surgery in order to achieve best long-term outcomes.

Source:

https://www.news-medical.net/news/20200131/Choice-of-anesthesia-may-change-metastatic-process-of-breast-cancer.aspx

Wow, that last one is a stunner! Something to clearly watch. Thanks much.

Look up ketorolac.... there is a lot of info on it being a good anesthesia choice that discourages mets.

Thanks debbew ...that's just so weird.

2019whatayear, the study used mouse models... they were resecting tumors in mice! The results might not apply in humans at all (but gives researchers some reason to think it might).

Apparently, the potential effect of anesthesia on long-term outcomes is an active area of research.

Here is a retrospective study done on bc patients a year ago which found no difference in long term outcomes between IV and inhaled anesthesia: https://anesthesiology.pubs.asahq.org/article.aspx?articleid=2712483 But *this* study refers to a previous study from 2016 (https://ekja.org/journal/view.php?doi=10.4097/kjae.2016.69.2.126) that did seem to show a difference between sevoflurane and propofol, but notes that the previous study's sample size was small.

Sorry the results aren't clear yet.

psychedelics....... interesting. Suggested reading, Michel Pollan "How to Change Your Mind" https://bioneers.org/how-to-change-your-mind-a-review-of-michael-pollans-latest-book-about-psychedelics-zmbz1805/ . These were being researched fairly intensively until tune in, tune out ,drop out, became the rage. Lots of interesting information in Pollan's book. Research seems to be starting up again .

I wouldn't count on LSD to reduce anxiety. It might for some but it could go in the complete opposite direction for others. There are just too many variables to take into consideration.

I would suggest seeing what you can find out about using low-dose psilocybin for cancer patients

Hi, I have joined this forum in the hope of sharing our experience...and your post seemed to be one of the only ones that references the circumstances surrounding my mother's passing...My name is Robyn, I reside in Australia. This post is difficult to write, however my sister and I feel it would have been valuable information to us if we had it late last year. Our gorgeous mother was diagnosed with Stage IV mets that had spread to her bones, Aug 2019. Completely out of the blue. We were advised that once the initial rounds of radio were complete a regime of Kisqali/Ribociclib would enable a diagnosis of 10 years. Only 10 weeks later mum was transferred from rehab to emergency then ICU with sudden onset of lung inflammation in both lungs. After 12 days, we had to make the devastating decision to turn of life support. 4 days later, whilst researching Kisqali/Ribociclib we happened upon an FDA warning directly identifying sudden lung inflammation as a side effect of this drug, and as such patients should have their lungs monitored. Our mother began Kisqali/Ribociclib on Sept 19 2019, 3 days after her 70th birthday. This FDA warning was released on September 13 2019. Our mother was an otherwise healthy woman, with a rich and loving life ahead, she did everything she could in ICU to give herself a chance, "i want to get better" was her anthem between oxygen masks. Eventually mum was intubated whilst her ICU and Infectious disease specialists tested for all possible types of infection/diseases/pneumonia possible. We have lodged documents with Novartis and they are requesting follow up. In no way do we want to deter women from this treatment, we were so happy mum had this option, Kisqali/Ribociclib would have let her and her children and grandchildren say hello each day and goodbye on our own terms if we had the chance. We only think it should be a safe playing ground and so have decided to share this information. we also believe it should be a fare playing ground and are at a loss as to why these alerts are not sent out globally, given they are used globally. We are heart broken, we are completely devastated as she was everything to us. Nothing can be done to bring mum back but we so do not wish upon anyone else. Just ask the question, is all.

Yes--Robyn and sister thank you for sharing that with this group and my deepest sympathies on the loss of your mother.

Not breast cancer, but this was posted recently on a Facebook cancer group I am in. It was interesting the negative effect of hyaluronic acid on myeloma. . . as hyaluronic acid is in many, many cosmetics. . . for it's plumping effect. . even cosmetic brands considered a bit "healthier" like Aveda use it. . .

https://margaret.healthblogs.org/life-with-myeloma/what-is-multiple-myeloma/myeloma-and-hyaluronic-acid/?fbclid=IwAR02EUHMlizg82fHwq4RO6jEvLqLq4v9ziU8KelyvccwyYV4a_xtB3bgY78

RobynKH , deepest sympthies for the loss of your mother. The more we share, the more learned

In terms of state laws, a new law in PA requires insurance companies to cover approved cancer drugs prescribed for metastatic patients (rather than forcing a "fail first" with cheaper drugs):

https://www.post-gazette.com/news/politics-state/2020/02/05/PA-sate-House-passes-bill-to-abolish-fail-first-approach-for-stage-IV-cancer-patients/stories/202002050138

(notes that "Legislatures in Georgia, Illinois, and Maryland have passed similar legislation in recent years.")

debbew: thanks for all your interesting posts!

lumpie: we are thinking of you & sending you well wishes

Really interesting about the bell. Since I don't care for the image of cancer as a "battle" or a "war", I was less than pleased with a "conquering hero" victory celebration. I did the necessary treatment. A quiet glass of wine would have been nice.

yw, santa, glad you found them interesting!

I'll add my thanks to marijen and mystical and all the others who post and comment, but especially Lumpie for starting and really running this thread (hope things are going well!).