Will molecular profiling/second opinion affect first line

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Anotherone
Anotherone Member Posts: 633
edited July 2019 in Stage IV/Metastatic Breast Cancer ONLY

I have tried giving info about my diagnosis and treatment but it does not seem to show it - ot may be it is just me who does not see it ..

In short I had Stage 3 Grade 3 IDC Her+ weakly Er+ in 2006 , had half of axillary nodes involved, had CMF and TAC, radiotherapy and herceptin for a year.

Now there are metastasis all over my lungs, massive ones, with lots of lymph nodes involved. Clear bones and liver , not sure about brain yet.

I am waiting for biopsy (bronchoscopy ) results and wondering whether at this stage I would benefit from second opinion and there is a point in delaying treatment until it is obtained or first line treatment will be pretty much standard and I may as well start it ASAP. I am 46 , fit and well otherwise.

I guess it will be chemotherapy with/without hormonals or herceptin and perjeta depending on biopsy results no matter what are the other possible results of Caris profiling ? Or do I misunderstand the topic. It is ridiculous that I have nobody else to ask about it .

I am in the UK so basically I wondered whether there are any first line treatments that I would better source privately rather than going with what NHS offers. Thank you ladies and it would be great if any of you could help - as you know it is nerve wracking having to deal with decisions on this scale with no information

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2019

    Yes, I am in the USA but as far as I know the standard first line of treatment for HER2+ Stage IV would be a taxane plus Herceptin and Perjeta. The taxane chemo would be for 6 months if you are tolerating it and responding, the H&P continues indefinitely. I didn't start anti-hormonals until my chemo was completed.

    This is based on the CLEOPATRA study - https://www.breastcancer.org/research-news/perjeta-boosts-overall-survival-for-some

    I wish you the best with your treatment.

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  • Anotherone
    Anotherone Member Posts: 633
    edited July 2019

    thank you olma. I expect them to book me tomorrow for a chat..

    I wonder why put a limit of 6 months on taxol if one is responding - why not to pursue it further..

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  • Anonymous
    Anonymous Member Posts: 1,376
    edited July 2019

    Since we continue on H&P and can remain stable that way, I think it's a matter of just conserving the treatment and the wear and tear on our bodies. I think they want to minimize any side effects that could develop and "save" the chemo for any such time that you might need it again....so that our cancer does not become resistant.

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