Grade 1 and high oncotype? Anyone

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Missybb
Missybb Member Posts: 5
edited July 2019 in Diagnosed and Waiting for Test Results

hi, i am awaiting oncotype results. I am grade 1 (high grade 1 tubular=1, nuclear=2, mistosis=2).. it is IDC 1.2cm with DCIS grade 3. Had lumpectomy with SNB 0/1. My ki67 is 35.8% which is why it got sent for oncotype. Clear margins, closes 1mm and had additional cavity shaves

Just wondering what sort of RS people got with these type of stats.

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  • FindingOptimism
    FindingOptimism Member Posts: 67
    edited July 2019

    My stats were similar to yours. Oncotype 13, recurrence rate 9% with tamoxifen


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  • FindingOptimism
    FindingOptimism Member Posts: 67
    edited July 2019

    My stats were similar to yours. Oncotype 13, recurrence rate 9% with tamoxifen


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  • Missybb
    Missybb Member Posts: 5
    edited July 2019

    finding optimism thanks for that. I hope mine is low teens too.

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  • Beesie
    Beesie Member Posts: 12,240
    edited July 2019

    Missy, are you high ER+ and PR+ or is one (or both) low? That, probably more than grade, seems to have a big impact on the Oncotype score. Having both a high ER+ and high PR+ (90%-100% positive) is more likely to drive a lower score. If one or both are positive but only slightly so, the score will be higher.

    That said, there are 21 genes that are measured to determine the Oncotype score, so there always could be some outlier that drives the score up or down.

    Good luck! Hope you get a low score!

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  • edj3
    edj3 Member Posts: 2,076
    edited July 2019

    Beesie, when you say positive but only slightly, what's the range for that? I could Google it, I know, but you have so much information already at your fingertips that I'm being lazy.

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  • Missybb
    Missybb Member Posts: 5
    edited July 2019

    hi, on the alfred scale i am er 8/8 and pr 7/8. Dont know the %. Yes, I would think lower score unless the high Ki67 is indicative of the other proliferation genes being high too. The waiting is a nightmare. Should know wednesday. Many thanks x

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  • Beesie
    Beesie Member Posts: 12,240
    edited July 2019

    Missy, that ER and PR should drive the score down.

    edj3, I don't have a specific range and I don't think there is one. My statement was more general than specific. The Oncotype score is calculated by summing together points for each of the 21 genes. Some genes add points into the total, driving up the score, while other genes subtract points from the total, driving down the score. ER and PR are among the most significant 'negative' factors, meaning that a high ER and PR will result in a large number to be subtracted from the score. This also means that the lower the ER and PR, the lower the subtraction from the score, so other factors that increase the score, such as Ki-67, will have more weight in the total.

    I have also noticed from a lot of women posting here that if IHC testing shows a positive but low ER or PR, the Oncotype method of measurement may actually show a negative ER or PR.

    Here's the Oncotype formula. I have highlighted in green the genes that are subtracted from the total (i.e. the ones you want to be high), and in red the genes that are added into the total (i.e. the ones you want to be low).

    image

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  • letsgogolf
    letsgogolf Member Posts: 263
    edited July 2019

    Missybb - My stats were very similar to yours with the exception of your Ki67. My grade was 2+2+1 for a score of 5. My Oncotype score was 3. Fingers crossed for you to receive a low oncotype score as well. Best wishes!

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  • Missybb
    Missybb Member Posts: 5
    edited July 2019

    Beesie, thanks for that. I was looking for that formula today.

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  • Missybb
    Missybb Member Posts: 5
    edited July 2019

    lets go golf, thanks for your reply.

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  • edj3
    edj3 Member Posts: 2,076
    edited July 2019

    Thank you, Beesie--slogging through the path reports (that have changed as additional analysis has been done) and not having anything other than a one page, no details report on the MammaPrint--well it's frustrating. Always appreciate your knowledge.

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