Newly diagnosed ER+, PR-,HER2-

So sorry you've been diagnosed. You will find lots of ER+/PR-/HER2- women here:

https://community.breastcancer.org/forum/137/topics/858729

Gigi, as you also had that lung cancer diagnosis, you could ask your doc if genetic testing is in order. Might help with determining your follow-up treatment.

Best of luck!!!

Well, one 'good' thing about grade 3 tumors is that they tend to be fast-growing and, therefore, more responsive to treatment! However, here's hoping your Oncotype shows low numbers!

Well a small percentage of us are er+ pr-, her2-. I had 2 tumors ilc and idc both 95% er receptors and 0% pr. My grades were 1 for idc and 2 for ilc. Both had mitotic scores of 1, slow growing. My oncodx came back at 34. Both tumors measured 1cm at greatest extent no nodes. I declined chemo and went for AI drugs made it 4 years. I am now 8 years NED.

Interesting thing about er receptor only behaves like triple negative as far as recurrence srsts but AI drugs are roughly 2x as effective for er+ pr- as tamoxifen.

If I were grade 3 I might have seriously considered chemo but as it was I was not willing to do it to possibly prevent recurrence.

For anyone interested..I just bumped up a thread for Long term Oncotype test survivors. My score was 46. I found that thread helpful.

I am an 9 year survivor of ER + PR - HER -, stage 1 BC Had bilateral mastectomy, chemo and on year 9 of anastrazole. NED

I was diagnosed with lung cancer about 3 years after BC diagnosis. Originally stage 1B, now stage 4. Doing well on current treatment.

Not sure if this is helpful-- I was er/pr+ her - but my oncotype showed I was closer to pr-. Onc said that pathology (pr+) ruled the day-- but I suspect I was a very lowpr+. Anyway, I am almost 11 years out----lumpectomy, - had chemo (oncotype 27) and radiation and AI for 5 years. All good- and I do my regular mammograms, onc visits and an MRI every other year--- this all seems to work for me--- I hope you get good news about your treatment... others are correct-- the treatments seem to work best on the more assertive tumors

I went to my post-op surgery appointment recently. Clean margins, no node involvement. 😎 My lumpectomy was 6/14/2019.

The only issues was the IDC was grade 3 and they found a friend next to it - medium-grade DCIS. And also the obnoxiously high Ki67 (93%!) - which we knew about from the biopsy. I'm ER+ (weak staining 75%), PR-(0%) and HER2-.

The next steps are what treatment options the team recommends. I go to my radiation oncologist July 1 and medical oncologist July 3. Back to the surgeon July 18th.

I am very curious on what my Oncotype score will be. I'm 66,

Gigibozo Thank you for starting this thread - I too was diagnosed with IDC, ER+/PR-/HER2- last year. I'm sorry you're going through this but welcome you to a wonderful family of people who will support and share and be your community whenever you want us. This website saved my ass last year when I felt lost! I don't drop in as much as I should, but will make a point of checking in more frequently as it seems there's always something to learn or something to impart to people who need information or just a pat on the back and a little comfort.

Please keep us in the loop as you go through your next months.

PatsyKB, my case is similar but I had 2 tumors 1 idc the other ilc both 1cm, my nottingham scores were 5 and 6, so grade 1 and 2 with mitotic scores of 1. ER 95% and PR 0%, her2 negative. I had a single side mx with DIEP reconstruction. I did 4 years on AI drugs, my oncodx score was 34. I didn't do chemo. I had no nodes and good margins so no radiation. Oncologist wanted me to do the chemo.

I found some information on the possible meaning of being pr negative, but in the studies most are weakly er positive and a bit more aggressive. There were 2 articles about the difference between tamoxifen vs anastrozole and it was encouraging to see anastrozole being almost 2x as effective.

As far as recurrence our case behaves more like triple negative. So the first 5 years is where nearly all recurrences happen. My oncologist says for along time researchers believe the absence of pr suggests the cancer is no longer feeding off estrogen. Not so sure about that since anastrozole seems to be working. There are theories about the aggressive behavior I had a couple links posted in the other thread. But again most of those were fast growing.

I am on year 8, no cancer. Have no idea how I got it, I had none of the risk factors as far as family history or based on my health and health habits. I get so tired of reading about exercise, weight and alcohol, bunch of meaningless noise atleast for my case.

hello everyone, i was operated on the 7th may 2019, the result came out on the 7th june. The diagnosis showed INVASIVE DUCTAL CARCINOMA then i did IMMUNOHISTOCHEMISTRY, the result showed ER=POSITIVE, PR= NEGATIVE HER2 NEGATIVE. for the ER, the mark is on no. 3 that is STRONG STAINING, meaning the proportion score is 3 and the intensity is 3= 6. now the doctor wrote this to me to buy for chemo: I.V Epirubin 150mg stat, I.V Cyclophosphamide 1g stat, Tab Capecitabine 1.5g 12 hrly for 2weeks, and in betweet the third and fourth chemotheraphy, ill have to undefgo the whole mastectomy.

What does "srsts" mean?

My wife's surgical pathology was different from the biopsy results. Her PR on biopsy was 97% (strong) but on surgical it was only 5% (weak). Her ER was slightly lower, 97% (strong) v. 90% (moderate).