Systemic Treatment Post Ibrance and Afinitor

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YellowRoses
YellowRoses Member Posts: 20
edited June 2019 in Stage IV/Metastatic Breast Cancer ONLY

Is there another targeted therapy pill to take after Ibrance and then Afinitor stop working? Or, is it back to an IV chemo such as Taxol?

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  • ann273
    ann273 Member Posts: 209
    edited June 2019

    Hello YellowRoses,

    I'm sure many will chime in here with multiple options. There's the newly approved Alpelisib (Piqray), Abemaciclib and Faslodex (which has proven to work even after Ibrance fails in a lot of cases) and then Xeloda (which is chemo, but not IV chemo.)

    Ann

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  • Grannax2
    Grannax2 Member Posts: 2,551
    edited June 2019

    I'm on my third cycle of Xeloda, I'll have a scan at the end of June. Therefore, I don't know if it's working yet but I'm hopeful. IF and AA failed.

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  • YellowRoses
    YellowRoses Member Posts: 20
    edited June 2019

    Thank you, Ann.

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  • YellowRoses
    YellowRoses Member Posts: 20
    edited June 2019

    Thanks, Grannax2.

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  • pajim
    pajim Member Posts: 2,785
    edited June 2019

    If you have the mutation, and 1/3 of women do, you can take Piqray. Else it's likely Xeloda or a trial. There are a bunch of trials going on for new hormonal treatments. Some are oral versions of Faslodex.

    I also tried Verzenio (with Faslodex), even though I had taken Fas and Ibrance. But that was after a year of Xeloda. Sadly it didn't do the job.

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  • YellowRoses
    YellowRoses Member Posts: 20
    edited June 2019

    Thanks, pajim.

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  • YellowRoses
    YellowRoses Member Posts: 20
    edited June 2019

    I really do appreciate your replies and look forward to others. Will be nice to walk into next med onc appt. with some ideas!

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  • EV11
    EV11 Member Posts: 127
    edited June 2019

    YellowRoses-- you might consider asking for a tissue biopsy or liquid biopsy to see if you have targetable mutations (esp. PI3K for alpelisib/Piqray) or have developed any ESR1 mutations. There are a number of promising oral SERD trials (a few require an ESR1 mutation but many don't) and a few immunotherapy trials that accept ER+ MBC patients (MORPHEUS is open a few centers; required progression on CDK4/6i and no chemo in the metastatic setting...); there are other options at various centers for IO as well.. Not sure where you live, so I can't suggest more that these broad considerations; but talk to your onc about trials if you are interested/willing. There are a a number of oral targeted meds (venetoclax is one I really like) in trials.

    Progression is so challenging-- it's hard to wrap your head around knowing your cancer has found a way around your current treatment; there's the fear about how the next treatment will effect you; worry about it's effectiveness; and the mental energy drain in contemplating all your options. It's A LOT to deal with and I am sending support your way.

    Elizabeth

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  • YellowRoses
    YellowRoses Member Posts: 20
    edited June 2019

    Thank you Elizabeth. I have had a genetic study done and this week will be meet with a doctor to talk about what you have suggested. And they aIso have tissue biopsy results. I do appreciate your help.

    This whole journey is not for sissies!

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