Chemotherapy with ILC

everetta
everetta Member Posts: 71
edited August 2019 in ILC (Invasive Lobular Carcinoma)

Are there any studies that anyone has found that demonstrate the ILC is responsive to chemotherapy. I keep hearing that ILC is responsive to hormonal but not chemotherapy. But I think there must be certain ILC's that do respond to chemotherapy--and is there a particular chemotherapy that gets a response.

· Share on FacebookShare on Twitter

Comments

  • karen1956
    karen1956 Member Posts: 6,503
    edited May 2019

    I was diagnosed in 2006 and had TAC chemo - my course of treatment was bilat, chemo, radiation, AI's and oophorectomy. I'm still here 13 years later dancing with NED....hopefully I'll stay this way for years to come. All the best to you.

    · Share on FacebookShare on Twitter
  • everetta
    everetta Member Posts: 71
    edited May 2019

    HI Karen,

    Thank you for your reply. So glad to hear that you have done so wonderfully and will be dancing later NED for all the years to come!

    · Share on FacebookShare on Twitter
  • LaCombattante
    LaCombattante Member Posts: 226
    edited May 2019

    I didn’t have chemo when I was diagnosed first time. My Oncotype score came back as 10, with no benefit of chemo. I was on Tamoxifen for four years and then switched to Femara.

    Fast forward to 2019: recurrence in auxiliary lymph nodes on the affected side, while still on Femara. This time I am doing chemo (EC-T); the tumor board had a heavy discussion of my case and with an exception of one doctor they all agreed that chemo is the best course of treatment for now.


    · Share on FacebookShare on Twitter
  • Meow13
    Meow13 Member Posts: 4,859
    edited May 2019

    Just curious do you know what percentages for er and pr receptors? I was under the impression that say 100% both er and pr positive would respond the best to hormone therapy. Maybe that isn't necessarily true.

    · Share on FacebookShare on Twitter
  • Anonymous
    Anonymous Member Posts: 1,376
    edited May 2019

    "...Despite these limitations, our study is the largest report to date that specifically analyzes outcomes of patients with ILC who receive endocrine therapy with or without adjuvant chemotherapy. Controlling for patient age and tumor stage, we observed no survival benefit from adjuvant chemotherapy for patients with stage I/II ILC. These survival outcomes are consistent with the known genomic characteristics of ILC and the very low rates of pCR after neoadjuvant chemotherapy. The public health impact of this study is substantial, because ILCs represent about 10% of invasive breast cancers.23,24 Because most patients have stage I or II disease, avoidance of ineffective chemotherapy will markedly reduce the adverse effects and economic burden of breast cancer treatment."

    That having been said, I did not see that this study didn't indicate focus on node + vs. node -. My MO strongly encouraged chemo for me because of my node + status, and I agreed with her and got ACT. Even if it was a small chance, I wanted that chance because of my + nodes.

    Here is the link to the 2017 write up, FWIW.

    https://onlinelibrary.wiley.com/doi/pdf/10.1002/cncr.30699

    · Share on FacebookShare on Twitter
  • everetta
    everetta Member Posts: 71
    edited May 2019

    Thank you to everyone for these responses. This study is helpful. I haven't read any studies that show that lobular is beneficial, but I think with positive nodes it could be and I think you made a wise decision. They say there are some lobulars that could benefit, perhaps ones with high oncotypes or particular types of lobular. Thank you for pointing out this study. I hope all continues to go well for you. These decisions are so hard.

    · Share on FacebookShare on Twitter
  • jessie123
    jessie123 Member Posts: 532
    edited May 2019

    One of my friends had a BMX 5 years ago for early stage ILC -- she had no node involvement, but she was ES - 25% and PR - 0. She did have to have chemo. They did not do an Oncotype score on her. Her second opinion was at M.D. Anderson. M.D. recommended Chemo, but a much stronger version than what was recommended locally. She opted for the lighter dose.

    · Share on FacebookShare on Twitter
  • kitkit
    kitkit Member Posts: 80
    edited July 2019

    Hello,

    We've had discussions before in which I said my doctor said that chemo was ineffective for lobular cancer. He repeated the same thing yesterday - said 90% not effective. I found article that confirms:

    https://www.ncbi.nlm.nih.gov/pubmed/28382636



    · Share on FacebookShare on Twitter
  • cathmg45
    cathmg45 Member Posts: 12
    edited July 2019

    Hi,

    My onc back in 2008 said he couldn't guarantee that chemo would be of benefit, but because the cells were pleomorphic, he advised that I do 4 rounds of Cytoxan and Taxotere. I would have been uneasy otherwise. It's in the rearview mirror now!

    Best of luck,

    Catherine

    · Share on FacebookShare on Twitter
  • mshar
    mshar Member Posts: 23
    edited July 2019

    For whatever it's worth, AC+T cleared up my (large) ILC tumor in my breast as well as my lymph nodes and bone mets. A recent biopsy showed a few scattered cells left in the main tumor site but nothing close to what it was before. I don't have any information about oncotype yet.

    · Share on FacebookShare on Twitter
  • FaithAndTrust
    FaithAndTrust Member Posts: 44
    edited August 2019

    hi everetta

    I was extremely blessed to achieve a PCR response to my node positive ILC so the CHEMO did a great job for me.

    I read all the time doctor's saying CHEMO doesn't work for lobular but this was obviously not the case for me.

    I believe it is worth risking the side effects of CHEMO which I found doable.

    I am very grateful for the CHEMO I received.

    Good luck with your decision.


    · Share on FacebookShare on Twitter

Categories