Ibrance Users greater than 24 months

Thank you for the information, Sandibeach. I really appreciate it! I know I have 3 bone mets and the bone mets are Er+, Pr+,Her2-. (Found on accident while having mri due to leg injury)The bone biopsy they did came back breastcancer. I have a mammogram, breast ultrasound, and breast mri tomorrow to try to find the bc. Then on Tuesday I have a biopsy of whatever they find. Then next Tuesday I have a chest and abdominal CT to check for other mets. I thought I'd wait to fill in my bio until I know a little more info. Thanks again for your kind words.

Thank you for the encouragement. I honestly appreciate it.

Thank you all for this hopeful thread. I was dx with bone mets in January 2011, de novo. (Became a member of bco.org at that time). Had chemo, lumpectomy, radiation. Then began Arimidex which kept me stable or nead for about eight years until bone scan this month showed progression in L1 vertebrae and a rib. I'd really been cruising along there, even allowing myself the heady thought that maybe I beat mbc or at least could get 15 years out of the Arimidex. So I'm feeling a big let down, like all the air went out of my balloon, even at the same time grateful that I had years on Arimidex. I feel scared and unsettled like when I was first dx. With news of progression, all those memories of that time have flooded back Into my thoughts.

This week I began Ibrance/Aromasin. I'd like to know at what point after beginning Ibrance did you first get scanned, and how often after that? I'd gotten Pet scans for several years after dx, then insurance only approved bone and ct scans. I'd like to know the kinds of scans everyone else gets.

I've also been getting zometa ivs all these years, every month at first then down to four times a year and last year went to every six months. There was some talk about me going on Xgeva and figure the onc will discuss with me at my appt with her in two months. I'd like to know what, if any, biophosphenates those of you with bone mets are on.

I'm appreciative of this thread.

Hi ladies! I was diagnosed in Feb 2015 at the age of 38 w/mets to my spine (T5 and L2). I've been taking tamoxifen and lupron for over four years. Unfortunately, this week, I progressed in recent scans w/new mets in my spine (S1) and liver. My MD is suggesting CDK 4/6 (Palbo/Ibrance). My question for all of you: Should I complement w/aromatase inhibitor (Letrozole/Femara) or SERD (Fulvestrant/Fasoldex). The standard seems to be the former, but recent PALOMA 3 study indicates better PFS w/the latter. Thoughts?

hi blooming - sorry to hear about your progression but amazing how good a long run you’ve had, especially while traveling the world at the same time!

I vote for Ibrance and Femera as well. I was reading a bunch of articles about the two options and from what I read, folks had longer PFS with Femera.

Also I hear that the falsodex shots hurt like a mofo - so personally I’d want to take the easier teeny pill.

Monday I start cycle 25!!!

Hi Blooming...I have been on Ibrance/Femara for 3 years now with little problem; however, I have been having back/shoulder pain and am having a scan next week to see what is going on. But the treatment so far has not been too bad. We shall see what the onc says...

A recent report in the literature states that Abemaciclib (Verzenio), unlike Palbociclib (Ibrance) or Ribociclib, can also inhibit CDK2, which is a kinase that cancers can use to get around CDK4.6 inhibitors:

"In cells and mice, abemaciclib inhibits kinases other than CDK4/6 including CDK2/cyclin A/E-implicated in resistance to CDK4/6 inhibition-and CDK1/cyclin B."

Given that Abemaciclib is also a stronger CDK4 inhibitor than Ibrance, it might make sense to move from Ibrance-Femara to Abemaciclib-Faslodex, has anyone had success doing that?