ACTHP vs. TCHP, which to pick?

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Betty-PA
Betty-PA Member Posts: 8
edited April 2019 in IDC (Invasive Ductal Carcinoma)

Need to select between ACTHP and TCHP for stage II Invasive Ductal Carcinoma treatment. Which treatment is better? Thanks.

2cm breast tumor, 1.5cm armpit node lump, grade 3, ER+/HR-/Her2+ (ER positive, but not very strong), had lumpectomy and axillary node dissection, 3 out of 14 nodes are positive.

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  • Moderators
    Moderators Member Posts: 25,912
    edited February 2016

    This is a really difficult question for us to answer here. You may want to look at this page, which may help guide your choices:

    IDC Treatments

    Maybe some others will chime in with what treatments they selected, and how they made the decision.

    Perhaps a second opinion would be helpful, if your insurance permits.

    We're thinking of you.

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  • ThePrincess
    ThePrincess Member Posts: 424
    edited February 2016

    I am almost exactly similar to you in size and receptors - my DR thought AC+ THP was a better treatment for that specific type AND that it is better tolerated than TCHP.


    Good luck!

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  • Betty-PA
    Betty-PA Member Posts: 8
    edited February 2016

    thanks so much for your reply. I really appreciate. But I am concerned about the heart damage and potential leukemia. We're you tolerated well during the ACTHP treatment?

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  • sh2016
    sh2016 Member Posts: 1
    edited April 2016

    Hello there! I am new to this board. I was diagnosed two weeks ago and am also facing a similar decision between TCHP and AC+THP. I have Invasive Ductal Carcinoma ER-/PR-/HER2 + 2.3cm tumor grade 3.

    I switched my care over to a new very well respected DR and she feels that AC+THP will be better. Given my age (38). She felt it was less damaging on the ovaries than TCHP.

    The hospital where I had my first consults- both doctors only spoke about TCHP and didn't even mention AC+THP.

    Curious to know what you decided and how it is going? What are your major SE?


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  • Moderators
    Moderators Member Posts: 25,912
    edited April 2016

    Dear sh2016, welcome to the BCO community. We are glad that you reached out and hope that you will find support and good information here to guide you. While you are waiting for others to check in tai a oak at this information on Chemotherapy Combinations on our website. Stay connected here and keep us posted on how you are doing. The Mods

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  • rebecca06810
    rebecca06810 Member Posts: 1
    edited June 2016

    What did you end up having? I have a heterogeneous 2.2cm tumor HR-, Her2 inconclusive with IHC, positive with FISH. I'm doing AC-THP to leave no stone unturned.


    Rebecca

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  • HappyHammer
    HappyHammer Member Posts: 1,247
    edited June 2016

    I was ER+ and HER2+++ and did TCPH- some neuropathy and such but all in all- doable!  NED at the LX- hugs to you all as you make your decisions!

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  • Moderators
    Moderators Member Posts: 25,912
    edited June 2016

    Dear rebecca06810,

    Welcome to the community. We hope that you will keep us posted and stay connected here. The Mods

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  • Positivepower11
    Positivepower11 Member Posts: 101
    edited June 2016

    I was pr+ , er- and Her2+ on Fish, the inititial recommendation was TCHP and then the tumour was found to be hetrogenious so the MO decidied AC + THp was a better protocol.

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  • Mommato3
    Mommato3 Member Posts: 633
    edited June 2016

    I'm also happy to hear that Kayb. My MO recommended AC-THP because I was young(er) and he felt the TCHP had a lot of gastrointestinal issues. I've had times where I've worried because it seems like most get the TCHP (or TCH). This makes me feel better!

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  • ThePinkRibbonEffect
    ThePinkRibbonEffect Member Posts: 4
    edited December 2016

    Hi,

    I was recently diagnosed with StageIIA ER/PR/Her2 Positive. I went to two different places and one suggested ACTHP and the other TCHP. Since mine has not spread (it's stage II because it's 2.8cm), the second doctor suggested TCHP since it has less long term risk, even though I'm young (only 32). I feel more comfortable with TCHP but I'm a little conflicted as there's no research between one over the other. I'm curious what you chose and how you're managing overall. I will be starting treatment in the next couple weeks hopefully. Still super new so any guidance greatly appreciated. Looks like some others have been in this position.

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  • Moderators
    Moderators Member Posts: 25,912
    edited December 2016

    Hi ThePinkRibbonEffect,

    Welcome to the BCO discussion boards! We're glad you found us.

    We're bumping this thread to hopefully yield some responses from other members here as this thread has been inactive for a few months.


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  • LilyCh
    LilyCh Member Posts: 193
    edited June 2018

    Hi HappyHammer,

    My wife just had a very similar Dx: 06/2018, IDC, Right, 2cm, Stage IIA, Grade 2, ER+/PR+, HER2+. For the treatments, we are wondering if Chemo should be first or surgery first. We are scheduling to see an oncologist to discuss about it. The surgical doctor said this morning that chemo first along with targeted therapy will have 85% chance to shrink the tumor and 40% chance to completely get rid of it. Is that the case?

    Biopsy and Breast MRI showed nodes are clean, would that be accurate or can node negativity only be confirmed after the surgery? If nodes are indeed positive(false from both Biopsy and Breast MRI, how likely?) and we choose chemo first instead of surgery, would that cause any problem?

    Thanks a lot

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  • Mquinning
    Mquinning Member Posts: 2
    edited February 2019

    I just had my first round of THP today. I'm triple positive IDC, I have three tumors, one IDC 2.5cm, two DCIS 1cm. Total area spanned 5cm. Measured 3.5cm on clinical exam three weeks ago. I was started on TCHP, first treatment was three weeks ago. Im very sensitive to medications. I didn't tolerate the regimen at all. I had grade 3 SEs for two weeks. However, upon exam my MO could find no measurable tumor after only two weeks!! She switched me to THP for toxicity and because I responded so well. She's confident it was the Herceptin I'm responding to. No AC. If I have residual disease, I will get Kadcyla in the adjuvant setting. Cool new treatment for HER/2 + disease. Low toxicity

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  • MissouriCatLady
    MissouriCatLady Member Posts: 977
    edited April 2019

    Mquinning, I'm done with chemo, and having a wire-guided lumpectomy tomorrow and SNB. My MO told me the same thing, if I have residual disease, we will use Kadcyla. I will take Herceptin and/or Perjeta until November as well. Best of luck to you.

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