Variant of Uncertain Significance in BRCA1
My mom has metastatic breast cancer . She was first diagnosed at 49 and metastasis were found at 54.
Now her only sister has MBC too (diagnosed at 70). She never wanted to do any check-ups previous to the mets diagnosis.
Their only female cousin also has stage III BC, diagnosed in her midd- 50s.
That would make 100% of women in their family generation having (advanced) breast cancer. There are no more female cousins.
My mom was tested and the report sais Variant of Uncertain Significante un BRCA1.
How can that be managed? It is neither positive nor negative...Very confusing. She goes to the genetist expert every year to seré if there is more research on her mutation.
If you or any family member was also tested Uncertain to BRCA, I would appreciate if you could share the approach your medical team followed in your case.
I am worried about myself and my cousins. The oldest is 43 and I am the youngest (almost 35). I also have a brother.
Thank you very much for your input,
Alicia
Comments
-
I have a VUS of BRCA 1. Until some research is done on the thousands of these variations, you will be none the wiser. However, given the high rate of breast cancer in your family, you should have regular checkups.
-
Perhaps both of you might consider looking up the PROMPT study. You can join by sharing your BRCA variation.
Withvolunteers pooling their data, the leaders hope to gain further knowledge regarding the significance of these more unusual mutations. It will help future generations make treatment decisions. The sponsors are a consortium of major US research centers/universities.
-
I joined prompt a while back since I have brca2 vus
-
Thank you for the replies. The last time my mum was to the genetist, It wasn't VUS anymore, but "likely pathogenic". I guess they gathered more data in those years. I could not find the exact mutation on the reports she just gave me (it is incomplete), but I hope I can ask for it.
It the meanwhile, I am going to do the genetic test my self. It cost about 575 euros in my city (Madrid, Spain) and It checks 18 genes.
I Will post the results
Alicia
-
Is there any study for people with other variations of unknown significance to join? I have one on TP-53.
In my tumor tissue, the systemic variant I have was present, plus a second TP-53 variant known to be pathogenic.
I am happy to join any studies that can help researchers understand BC better.
Categories
- All Categories
- 679 Advocacy and Fund-Raising
- 289 Advocacy
- 68 I've Donated to Breastcancer.org in honor of....
- Test
- 322 Walks, Runs and Fundraising Events for Breastcancer.org
- 5.6K Community Connections
- 282 Middle Age 40-60(ish) Years Old With Breast Cancer
- 53 Australians and New Zealanders Affected by Breast Cancer
- 208 Black Women or Men With Breast Cancer
- 684 Canadians Affected by Breast Cancer
- 1.5K Caring for Someone with Breast cancer
- 455 Caring for Someone with Stage IV or Mets
- 260 High Risk of Recurrence or Second Breast Cancer
- 22 International, Non-English Speakers With Breast Cancer
- 16 Latinas/Hispanics With Breast Cancer
- 189 LGBTQA+ With Breast Cancer
- 152 May Their Memory Live On
- 85 Member Matchup & Virtual Support Meetups
- 375 Members by Location
- 291 Older Than 60 Years Old With Breast Cancer
- 177 Singles With Breast Cancer
- 869 Young With Breast Cancer
- 50.4K Connecting With Others Who Have a Similar Diagnosis
- 204 Breast Cancer with Another Diagnosis or Comorbidity
- 4K DCIS (Ductal Carcinoma In Situ)
- 79 DCIS plus HER2-positive Microinvasion
- 529 Genetic Testing
- 2.2K HER2+ (Positive) Breast Cancer
- 1.5K IBC (Inflammatory Breast Cancer)
- 3.4K IDC (Invasive Ductal Carcinoma)
- 1.5K ILC (Invasive Lobular Carcinoma)
- 999 Just Diagnosed With a Recurrence or Metastasis
- 652 LCIS (Lobular Carcinoma In Situ)
- 193 Less Common Types of Breast Cancer
- 252 Male Breast Cancer
- 86 Mixed Type Breast Cancer
- 3.1K Not Diagnosed With a Recurrence or Metastases but Concerned
- 189 Palliative Therapy/Hospice Care
- 488 Second or Third Breast Cancer
- 1.2K Stage I Breast Cancer
- 313 Stage II Breast Cancer
- 3.8K Stage III Breast Cancer
- 2.5K Triple-Negative Breast Cancer
- 13.1K Day-to-Day Matters
- 132 All things COVID-19 or coronavirus
- 87 BCO Free-Cycle: Give or Trade Items Related to Breast Cancer
- 5.9K Clinical Trials, Research News, Podcasts, and Study Results
- 86 Coping with Holidays, Special Days and Anniversaries
- 828 Employment, Insurance, and Other Financial Issues
- 101 Family and Family Planning Matters
- Family Issues for Those Who Have Breast Cancer
- 26 Furry friends
- 1.8K Humor and Games
- 1.6K Mental Health: Because Cancer Doesn't Just Affect Your Breasts
- 706 Recipe Swap for Healthy Living
- 704 Recommend Your Resources
- 171 Sex & Relationship Matters
- 9 The Political Corner
- 874 Working on Your Fitness
- 4.5K Moving On & Finding Inspiration After Breast Cancer
- 394 Bonded by Breast Cancer
- 3.1K Life After Breast Cancer
- 806 Prayers and Spiritual Support
- 285 Who or What Inspires You?
- 28.7K Not Diagnosed But Concerned
- 1K Benign Breast Conditions
- 2.3K High Risk for Breast Cancer
- 18K Not Diagnosed But Worried
- 7.4K Waiting for Test Results
- 603 Site News and Announcements
- 560 Comments, Suggestions, Feature Requests
- 39 Mod Announcements, Breastcancer.org News, Blog Entries, Podcasts
- 4 Survey, Interview and Participant Requests: Need your Help!
- 61.9K Tests, Treatments & Side Effects
- 586 Alternative Medicine
- 255 Bone Health and Bone Loss
- 11.4K Breast Reconstruction
- 7.9K Chemotherapy - Before, During, and After
- 2.7K Complementary and Holistic Medicine and Treatment
- 775 Diagnosed and Waiting for Test Results
- 7.8K Hormonal Therapy - Before, During, and After
- 50 Immunotherapy - Before, During, and After
- 7.4K Just Diagnosed
- 1.4K Living Without Reconstruction After a Mastectomy
- 5.2K Lymphedema
- 3.6K Managing Side Effects of Breast Cancer and Its Treatment
- 591 Pain
- 3.9K Radiation Therapy - Before, During, and After
- 8.4K Surgery - Before, During, and After
- 109 Welcome to Breastcancer.org
- 98 Acknowledging and honoring our Community
- 11 Info & Resources for New Patients & Members From the Team