Anyones path report say Lobular Like

Mine showed IDC with Lobular features on one report and Mixed type on another report. I was under the impression that E-Cadherin positive tumors were IDC and not Lobular although they could have Lobular features. I know mine was also Positive for E-Cadherin. I will have to double check the notes that I have on this.

I believe I would speak to the pathologist. Is that within the rules?

I agree with you. I don't think Lobular would stain positive. I am guessing it's actually IDC with Lobular features as in my case. I am going to dig out my reports to see exactly what they say.

Sadly, ILC/IDC are pretty much treated the same regardless of type; oncotype scores can often keep one from having chemo. I didn't have any of that testing because I had positive nodes and considered a different animal than others, so chemo was highly recommended, although I supposed I could have refused it. Since I embraced all my treatment as giving me even a hair's-breadth chance of kicking c to the curb, I wanted every available treatment I could get. I was in great health and knew I could handle the rigors of all my treatment; others can't, though, and that's okay.

I would like to share that ILC has a tendency to both hide from scans like mammos and has a higher tendency to be multi-focal. If you've ever had a mammo that revealed dense breast tissue, that will make it even harder to detect any problem in the future. Because I had ILC and very dense breasts, I opted for the BMX with recon. It was not an easy decision, and I took nearly 2 years to make it. Since I had 5 "clear" mammos over 5 years that didn't show that I had cancer, I couldn't see myself trusting mere scans ever again.

Claire in AZ

Hi All

These reports can be so confusing to understand.  My pathology says moderately differentiated infiltrating lobular carcinoma with focal ductal features, Elston Grade II  the longest span 1.2 cm the entire craniocaudal dimension measures 2.9 cm  .   Irregular margins and avid enhancement.   The tissue core with a focus suggestive of residual DCIS.   Gee I only know the doctor said I had Invasive lobular carcinoma he never mentioned anything about ductal.   ER+PR+   >90% variable, focally >90%     HER2-Neg.   Ki-67  25-35%  Are these bad odds???  Does anyone understand this?

Dakrok and all, yes it is frustrating to have a mixed or unclear diagnosis, but stage and grade are more predictive than the ILC/IDC distinction. Your 1A stage is very good. The high ER and PR numbers mean the anti-hormonal therapy prescribed should work well for you in preventing recurrence in your other breast as well as elsewhere in your body, even if there is/was some DCIS. The Ki-67 test is old technology and most doctors disregard it now. So overall, in my layman's opinion, you have good odds.

I had no problems with the radiation part of treatment. It was pretty easy and mine was left side and included all nodes except intramammary. Best wishes for a easy and speedy process! Arimidex has also been easy with no side effects at all after almost 2 years. Only issue has been development of Osteopenia and not getting along with Boniva. Switching to Fosamax on Friday.

Jessie123 I am familiar with Lupron injections. I had to give those to myself years ago when I was trying to get pregnant via IVF. Had to shut down estrogen prior to going on Pergonal injections each cycle. I wasn't on it for any extended period of time so I am not aware of any damage to my bones from it. My bones were fine 2 years ago when I had a DEXA Scan but after 2 years on Arimidex I have osteopenia of the lumbar spine. Just barely in the osteopenia range for now but I don't want it to get worse. My sister has been on Arimidex for 4 years and now has gone from osteopenia to Osteoporosis. She is on Prolia injections every 6 months.

My understanding of e-caderin is that it is a test to make sure what type of carcinoma you have, i.e. lobular or ductal. At first mine was diagnosed as Lobular, then when the first report came back it was diagnosed as Ductal and then the 2nd report said it was Lobular. When I queried this my Oncologist e said it was Lobular behaving like Ductal The only reason they knew it was Lobular is that they did an ecaderin test on it and that proved it was Lobular. I don't think it makes any difference whether it is Lobular or Ductal to tell you the truth. I think whether it has spread is more important. Size doesn't seem to make a huge difference either. I had a 2 cm tumour and a friend had a 5 cm tumour but mine was invasive and hers wasn't. I had to have chemo and she didn't.

So what exactly is ecaderin then ?