High Ki-67, but low grade and stage?

Thank you so much! I used the er and pr as it was on my path report...i only have one number of 100 percent for both er and pr. If i plug in 100 on both it gives me a score in the twenties. If i plug in 300 it gives me 12 to 14. I called the lab. They cant rush it. It was a mistake made by the pathologist. All about specimen id numbers not matching up with their documentation. Now im skeptical of the entire process.

Thank you for the support. Cancer sucks!

I used that formula and it came up with numbers in the 20s. My score was much less. Grade and Ki-67 are subjective to the pathologist.

agree with KB. I'm sorry for the added stress. Waiting is hard enough. Your high PR is in your favor. Lower PR drives your score up. Hang in there

It is always possible to talk to the folks at Genomic Health, the maker of the Oncotype Dx.  I called them a few times!

So sorry to hear about pathology error in sending sample.  I got to know the pathology people- actually went in to meet them- because my samples were being sent all over the place. Nervewracking. I actually had my Oncotype done a second time and made sure it was the right tissue block.

I had grade 3 (one lab said grade 2), uncertain HER2 (finally resolved as negative), KI67% at 20, and Lymphovascular invasion, focal.

But my Oncotype score was 8. Go figure.

It is possible, someone told me, that the healing biopsy site might increase the Ki67% because healing cells are proliferating. I have no idea if this is true.  For me, the other thing was that my biopsy results were HER2+ but post surgical results were equivocal then negative. I was told that biopsy result may have had a lot of DCIS in it, which tends to be HER2+.

So this stuff is complicated.

I went with the Onctoype score and had no chemo. None of us will ever be certain.

KI67% is only one of several proliferation measures in the test. I would have thought, with LVI, that my invasiveness score would have bumped it up, but maybe 95% ER and 80% PR bumped it way up.

Thirty percent of grade 3's have low Oncotype scores. Nothing is as it seems!!!!

I called the Genomics lab yesterday and all thry could tell me is that the specimen id number on the documentation from the order sent initially didn't match the specimen id number they received. Took them 10 days to get the specimen and then 7 days to do anything with it! So when your told 10 to 14 days that's after they recieve the specimen! So frustrating!!!

that is good to know it makes me hopeful. Did you multiple your hormone receptors by the different levels and add them

Before you plugged them in? My score has been delayed as well and so anxious .

So sorry Cjzach10 I sympathize and hope you get your results this coming week

my ki is 30. What is yours? I know all this waiting is painfu

mine was also 30

Thanks for the list kbee I think i will ask for all of those things!

Mine was the opposite, my Ki-67 at biopsy were low both in the breast tumor and lymph node (8% and 7.5%) but had high grade - grade 2 to 3. I had chemo before surgery and never got oncodx.

hi meow. Yes this is the same one as I posted above but maybe listed under another website ? My score varies as my range for Er is 98-100% so I put 300 for Er and feel good about that but my range for Pr is 41-50% so when I do what they say here to calculate:

All the required data is generally present in the surgical pathology report. The hormone receptor results will require the semi-quantitative H-score. If not reported initially, this can be easily calculated by the case pathologist by reviewing the immunohistochemical (IHC) stain slides. H-scores are calculated based on percentage of positive cells showing none, weak, moderate, or strong staining intensity. The score is given as the sum of the percent staining multiplied by an ordinal value corresponding to the intensity level (0=none, 1=weak, 2=moderate, 3=strong). With four intensity levels, the resulting score ranges from 0 (no staining in the tumor) to 300 (diffuse intense staining). For e.g. a tumor showing no staining in 10% cells, weak staining in 30% cells, moderate staining in 40% cells, and strong staining in 20% cells; the H-score will be calculated as follows: (0x10)+(1x30)+(2x40)+

I could have anywhere from 120 up so not sure. I enter it a bunch of different ways and I get anywhere from 16 to 20.

My Oncotype score was 52 and Magee equation scores averaged 28. I'm hoping the Magee scores are more accurate!

I don’t know I still waiting on my score that’s why I am making myself crazy trying to figure out what it will be. I should stop obsessin

Cjzach10 I want to call the genomic lab. Can I call and just give my name and they will give me the status

They should talk to you too. The number i got us 1 855 500 0275. Good luck i hope you get some answers!