Low dose tamoxifen -a feasible option for DCIS, LCIS, & ADH
Fron SABCS
"SAN ANTONIO – A low-dose treatment of tamoxifen – 5 mg daily rather than the conventional 20 mg daily – appears to offer women protection against recurrence of early stage breast cancer and also reduces adverse events that often accompany tamoxifen cancer prevention therapy, researchers reported here."
Comments
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Very interesting. Guess I’ll stop feeling guilty for only doing fouryears. (Although I realize my case is not the same since I had IDC.)
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That is interesting. I always wondered about the one dose for all.
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Wow too late for me to take advantage of a lower dosage but I’m still blessed. Manageable side effects and 7 years out last August.
Diane
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Read our take on this study:
Low-Dose Tamoxifen May Be an Option to Reduce Risk of Recurrence, Invasive Disease After Non-Invasive Breast Cancer
December 18, 2018
A low dose of tamoxifen after surgery reduced the risk of recurrence, as well as the risk of new invasive disease, in women diagnosed with hormone-receptor-positive breast intraepithelial neoplasia. Read more... -
"Most DCIS, ADH, and LCIS are hormone-receptor-positive. So most people diagnosed with DCIS, ADH, and LCIS take hormonal therapy to reduce the risk of developing invasive disease, as well as the risk of the non-invasive disease recurring"
This is NOT true of ADH & LCIS. Doctors are frustrated by the low number of women agreeing to take prophylactic medication offered since it has shown to be so effective. MOST women with ADH & LCIS choose NOT to take tamoxifen or an AI.
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I am so thrilled to see this study published. Wish it applied to IDC because I do feel the 20mg per day dose of tamoxifen is too heavy at least for me. But I will take it as long as I can.
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This has always been my plan since quitting Tamoxifen due to too many SE's. I realize that endocrine therapy is important, but I just couldn't suffer any more problems while trying to figure out the rest of the problems. Know what I mean?
I've read some other limited research with some good results on really low doses - sometimes only 5-10 mg per week! I'm hoping to try again, building up slowly and backing down again if too much. We all are so different that it seems that different dosages would be a distinct possibility.
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