Anyone on Taxotere, Perjeta and Herceptin

SFmama

I had surgery first after consulting with two oncs. Who said as long as within 1 to 2 weeks. My largest at the time was thought to be 1.8. Took a lot to get myself scheduled 2 1/2 weeks later bilateral mastectomy because surgeon thought no hurry cause all oncs say that. Got another surgeon and it was 2.2 with no lymph involvment thank god!

2nd opinion awesome  onc at Roswell cancer institute suggested Perjeta right from the start but was 2 1/2 hrs away from me so he agreed to work with onc in my home town. He had to convince her to do this even after I told her my insurance covers it and finally called to tell her how to request from insurance and it passed no problem. Had first Herceptin, Perjeta, taxotere and carboplaten 12/16/15 next 1/6 for total of 6 every 3 weeks and then Herceptin and Perjeta every 3 weeks for a year.

Hometown onc was convinced Perjeta before surgery only Roswell onc said all studies and NCC said should go with Herceptin. Needless to say, I did not choose this onc and am extremely unhappy with her care but having hard time finding another 

Hi mdcaley and welcome to Breastcancer.org!

We're sure the other members here will weigh in soon with their thoughts. In the meantime, you may want to check out the main Breastcancer.org site's page on Lumpectomy vs. Mastectomy to help you make your decision.

We hope this helps! Looking forward to hearing more from you.

--The Mods

hi, I am also getting neoadjuvent therapy. I am meeting with my surgeon on 1/19. I have cancer in my left breast with lymph node involvement. I have decided that I want a bilateral mastectomy. I have cysts in righty and have a history of having to get diagnostic mammograms. I just know myself. I know that I will worry everytime I need to go get checked. I feel that while it doesn't take the risk completely away, it will reduce my chances of having to do this again. I also want my breasts to look the same as each other. I agree, it's a personal choice. Good luck with your decision.

Hi,

My mother starts six cycles of THP this coming Monday. She was originally DX'd three weeks ago as Stage 3 with a 5cm breast tumour and lymph node involvement; after recent PET scan she's now Stage IV with a single bone lesion. She's due a bilateral mastectomy after the first six cycles.

Anyone out there able to share insights into how best to cope with side-effects? The team will brief us the day she starts chemo, but this doesn't give me a whole lot of time to prepare.

I've read a lot about gastro-intestinal SEs. I had ulcerative colitis a couple of years ago and used Slippery Elm, Smecta and (of course) imodium to control my symptoms; unsure whether using Smecta (or other forms of clay) is contraindicated with THP. Have also read about using activated charcoal (link to JHOP study).

Does anyone have any experience of this?

Thanks ;-)

A

Reviving an old thread as I am starting this cocktail next week. Port was put in yesterday, so far doc isn't giving me Nuelasta which is a blessing, that stuff is the devil.

Saw the PA yesterday, she wants to do Nuelasta ACK!! NOOOOO!! I mean, I'll do what I have to but NOOOOO.

starting my Treatment on Wednesday. My Chemo regimen is Taxotere, Carboplatin, Perjeta, Herceptin and Neulasta. I am hoping for no side effects. How long before the show up

I had the same treatment. I received 6 treatments......one every three weeks. I took the Neulasta shot.

How are you doing

dmwaser.....I will be starting the TCHP regimen in about a month. Having a mastectomy next week (left side). Can you let me know what type of side effects you have been getting and what the fatigue level is or can you compare it to like a flu, etc? Any help you can offer would be appreciated. Hope you are doing well. Thanks!

Hello. I will have round 2 of 6 Wednesday of TCHP and was wondering, do things get worse on this treatment, or do they stay about like the first round? I know everyone is different and will have to deal with whatever comes my way, just thought I would ask some of you warriors that have finished off your treatment. My best wishes to you in your journey. Thank you, Lisa

I’m on day 11 from my second infusion of TCHP and I’m still tired. This one was a little harder than the 1st, a little more tired, nauseous, and D. But, I’m managing and hope it goes well for you. We are warriors!!

I am also on TCHP and just had round 4 of 6 last week. I feel horrible for at least 10 days. I get nausea and body aches and mouth sores. The mouth sores are the worse. At least with nausea you can take medicine but mouth sores the mouth wash only numbs you for some time then you feel the pain and eating is a challenge.

I also got a horrendous acne rash. It was bad. Face red and acne boils all over that would bleed. Horrible. My doctor gave me doxycycline and it has helped.

My first infusion put me in the hospital.

I was on Taxotere, Perjeta, Herceptin & Carboplatin. I finished it up in August, 2017. I had 6 cycles of it followed by 12 cycles of maintenance Herceptin. I was very lucky. I had mild nausea & fatigue. I had my infusion on Friday and took that day & the following Monday off from work for a rest day. If I ate anything tomato based I would have bad heartburn. But I could usually take the nausea meds and it would take care of it. I never had mouth sores. I was constipated so I had to take a stool softener which kept me more like having diarrhea the whole time. My voice was hoarse the whole time and one of my eyes was cloudy, would run and was red and irritated just about the whole time. But given the list of side effects I know I was very lucky.

Sunocean- way to go! You are almost done!

Tuesday I go in for my 4th infusion. I’m ready to be done. This round was harder than the first 2 and I got a cold. Hoping for minimal side effects for everyone and strength and patiences.

We are stronger than this and will be okay!

Hugs to everyone

Hi, I'm Sofia. I'm stage IV on Herceptin + Perjeta + Docetaxel (Taxotere) + Denosumab. I was first dx in 2012 (34 years old) with stage I and HER2 - . I did a mastectomy, chemo, tamoxifen for five years (and zoladex for 2). In April 2018 I was going to finish Tamoxifen (5 year mark) and it was also my 40th birthday. I started having a lot of pain and found mets in bones, liver and a pleural effusion. I started chemo immediately (convencional chemo for HER2 -) since my doctor thought I was in risk of paralysis but the results were disappointing (markers wouldn't go down much) so I went for a liver biopsy and we found out that my cancer had "mutated" into HER2+. So I changed to this H+P+T+D. I'm doing it every 3 weeks and the Denosumab shot every 4 weeks. Markers went down from over 1300 (back in April/ May) and 3 weeks ago were around 150, so my doctor was feeling optimistic. I had 10 taxotere total (and am very swollen from toxicity but no heart problems). I did 3 cat scans a few days ago and I'm still waiting for the results. Today I'm freaking out because I have a lump on my left rib that suddenly seems bigger. Can't understand how markers keep going down and now a tumor seems to be growing. Can't do anything now but wait for the scans result.