Low dose tamoxifen -a feasible option for DCIS, LCIS, & ADH

Options
besa
besa Member Posts: 1,088
edited December 2018 in Clinical Trials, Research News, Podcasts, and Study Results

Fron SABCS

"SAN ANTONIO – A low-dose treatment of tamoxifen – 5 mg daily rather than the conventional 20 mg daily – appears to offer women protection against recurrence of early stage breast cancer and also reduces adverse events that often accompany tamoxifen cancer prevention therapy, researchers reported here."

https://www.medpagetoday.com/meetingcoverage/sabcs...

· Share on FacebookShare on Twitter

Comments

  • farmerlucy
    farmerlucy Member Posts: 3,985
    edited December 2018

    Very interesting. Guess I’ll stop feeling guilty for only doing fouryears. (Although I realize my case is not the same since I had IDC.)

    · Share on FacebookShare on Twitter
  • Meow13
    Meow13 Member Posts: 4,859
    edited December 2018

    That is interesting. I always wondered about the one dose for all.

    · Share on FacebookShare on Twitter
  • edwards750
    edwards750 Member Posts: 3,761
    edited December 2018

    Wow too late for me to take advantage of a lower dosage but I’m still blessed. Manageable side effects and 7 years out last August.

    Diane

    · Share on FacebookShare on Twitter
  • Moderators
    Moderators Member Posts: 25,912
    edited December 2018

    Read our take on this study:

    Low-Dose Tamoxifen May Be an Option to Reduce Risk of Recurrence, Invasive Disease After Non-Invasive Breast Cancer
    December 18, 2018
    A low dose of tamoxifen after surgery reduced the risk of recurrence, as well as the risk of new invasive disease, in women diagnosed with hormone-receptor-positive breast intraepithelial neoplasia. Read more...

    · Share on FacebookShare on Twitter
  • MelissaDallas
    MelissaDallas Member Posts: 7,268
    edited December 2018

    "Most DCIS, ADH, and LCIS are hormone-receptor-positive. So most people diagnosed with DCIS, ADH, and LCIS take hormonal therapy to reduce the risk of developing invasive disease, as well as the risk of the non-invasive disease recurring"

    This is NOT true of ADH & LCIS. Doctors are frustrated by the low number of women agreeing to take prophylactic medication offered since it has shown to be so effective. MOST women with ADH & LCIS choose NOT to take tamoxifen or an AI.

    · Share on FacebookShare on Twitter
  • Rah2464
    Rah2464 Member Posts: 1,647
    edited December 2018

    I am so thrilled to see this study published. Wish it applied to IDC because I do feel the 20mg per day dose of tamoxifen is too heavy at least for me. But I will take it as long as I can.

    · Share on FacebookShare on Twitter
  • NotVeryBrave
    NotVeryBrave Member Posts: 1,287
    edited December 2018

    This has always been my plan since quitting Tamoxifen due to too many SE's. I realize that endocrine therapy is important, but I just couldn't suffer any more problems while trying to figure out the rest of the problems. Know what I mean?

    I've read some other limited research with some good results on really low doses - sometimes only 5-10 mg per week! I'm hoping to try again, building up slowly and backing down again if too much. We all are so different that it seems that different dosages would be a distinct possibility.

    · Share on FacebookShare on Twitter

Categories