Assoc. of Breast & Ovarian Cancers With Predisposition Genes

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chocomousse
chocomousse Member Posts: 157
edited October 2018 in Genetic Testing

Key Points

Question Which non-BRCA genes are associated with breast or ovarian cancer and what are the magnitudes of those risks?

Findings In this study assessing whole-exome sequencing results from 11 416 patients with breast cancer, ovarian cancer, or both and 3988 controls, an increased risk of breast cancer was associated with PALB2, ATM, CHEK2, and MSH6genes, whereas MSH6, RAD51C, TP53, and ATM genes were associated with an increased risk of ovarian cancer.

Meaning In addition to confirming several well-known breast or ovarian cancer gene associations, this study identified MSH6 and ATM as possible moderate-risk breast and ovarian cancer predisposition genes, respectively.

https://jamanetwork.com/journals/jamaoncology/full...

Edited by Mods to make link hot.


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  • SimoneRC
    SimoneRC Member Posts: 419
    edited October 2018

    Hi Moderators!

    This article looks like a subscription article. Any way you can post the full text?

    Just been advised to have salpingo-oophorectomy. Interested to read this study.

    Thanks

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