Dogs Primarily Develop Triple Negative Breast Cancer

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sillyoldrabbit
sillyoldrabbit Member Posts: 124
edited October 2018 in Triple-Negative Breast Cancer

I came across this interesting research study today:

High Frequency of Triple Negative Mammary Carcinomas in the Dog as Model of Human Breast Cancer

So far, I haven't found any explanation for why this is the most common type of mammary cancer in dogs. It seems strange that the risk of breast cancer in dogs is reduced by early spaying. If lifetime hormone exposure increases the risk, then why are the majority of canine tumors triple negative?

Anyone have any thoughts on this?

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  • WC3
    WC3 Member Posts: 1,540
    edited October 2018

    I'm guessing earlier spaying prevents the mammary glands from fully developing.

    My dog had one heat before she was spayed and developed white discharge in one teet during it. The vet said it was a false pregnancy. 8 years later she developed cancer in that mammary gland. It was a spindle cell carcinoma, which is rare in canine mammary glands. We could only afford surgery. The vet thought she got clear margins but it started growing back instantly, and though that type of cancer only rarely metastasizes in dogs, she had potential evidence of it in her lungs. We didn't have the money at the time for a second surgery but she lived about a year. She was having breathing problems when we euthanized her so I guess it was in her lungs and a second surgery wouldn't have really helped.

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  • JoE777
    JoE777 Member Posts: 628
    edited October 2018

    Jumping in as a rabbit owner- if females aren't spayed, they develop mammary cancer and often uterine because they have a constant wash of estrogen. it lengthens their life considerably. As long as 8 years. Only survive about two years in the wild

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