HER2 test was Equivocal

Sadlynew2018 · August 2018

I'm so scared on this. They are submitting it for a FISH test apparently. Is this common? I guess my fear is, if I'm borderline and maybe need the treatment for triple positive but they err on the side of classifying me as negative, it could get bad. This is all so frightening. Has anyone else dealt with “equivocal" results? Google has injected such fear into me.

KathyL624 · August 2018

I was equivocal and then negative at FISH testing. Sometimes I worry too

Sadlynew2018 · August 2018

Kathy - I really need to stop googling. But it’s so tough, especially in the beginning. How was treatment for you?

carmstr835 · August 2018

I was equivocal, then they did the FISH and that was equivocal as well, they will continue to test until they come to +1 or less or +3. If your not sure, have a 2nd opinion, my Dr.'s did and found 2 different labs declared it positive.

SpecialK · August 2018

sadly - here is another recent thread that has some good info on equivocal Her2 testing.

https://community.breastcancer.org/forum/80/topics/866354?page=1#post_5254228

lulabella · August 2018

hi there...I was equivocal and then negative at FISH testing and then had the mastectomy surgery and came back HER2+ after they biopsied the tumor.

Ingerp · August 2018

Just chiming in to say equivocal HER2 is very common. Anyone with “FISH” in their profile initially had an equivocal result.

JaBoo · August 2018

Sadlynew, check the other thread that SpecialK linked above. Some useful links there!

My result was initially equivocal too, it happenes a lot. The timeline was as follows:

I had biopsy, IHC showed 2+

They sent it for FISH, which takes longer

Meanwhile I had lumpectomy and IHC in my pathology result says 3+

Shortly after the operation the FISH result came in as positive

GraceB1 · August 2018

I was negative at biopsy and then borderline with the FISH. 6.0 is the cutoff and I was 6.1. After a discussion we went ahead with the herception. I had insurance and was in relatively good health. I also had a really rare type of cancer and wanted to throw everything at it as there are no standardized treatment protocols.

HER2 test was Equivocal

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