er+ pr- her2- onca 25 Chemo or not

Is the mammaprint a possibility? My doctor recommended the mammaprint as it does not have the intermediate issue. The other nice thing about this test is that it can tell you if you are a luminal a or a luminal b. I was classified as a luminal b, so that meant chemo. Luminal a's have a better prognosis and do not see much benefit from chemo. Not sure how much this test would be to pay out of pocket, but it left me feeling more comfortable with the decision to have chemo.

have s question : for which hormonal status they offer msmmaprint test- for triple negative or for er positive?

I m 41, er pr positive, her 2 negative , but grade3, stage1, I had a tiny micromet in 1 lymph node- I m doing chemo TC , even it’s will give me6-7% for survival . I saw the leading specialist director of breast oncology and was suggested chemo

Henry8 -

My oncotype number was 24 (I'm also HR+/PR-/HER2-); IDC; very small tumor; no node involvement; stage 1, grade 1; post-menopausal (WAY post...I'm 67).

It's important to remember that many medical oncologists treat HR+/PR-/HER2- the same way they treat HR+/PR+/HER2- . I decided not to overthink it and drive myself crazy.

The TayloRX study came out just before I received my Oncotype score - good timing. Bummed as I was that the test hadn't given me a definitive answer, I pressed my oncologist who, instead of telling me what to do, gave me all the possible information I needed in order to make my mind up. I really appreciated that and benefitted, I believe, from being treated as a partner and an adult. He said that if I chose not to do chemo, we'd move right into using an AI shown to be very effective for patients like me (post-menopausal), Letrozole (generic Femara) in preventing recurrence. He pointed out that my absolute benefit from chemo, if I chose to go that way, would be so minimal that it could be negated by the very likely side effects from chemo. Naturally, I wanted more opinions. My primary care physician's opinion was that I should forego chemo. I also contacted a second oncologist in my local office of my primary oncologist's practice; her opinion was a definite "no chemo."

So I feel strong and good about my decision. For those of us who are post-menopausal, the AI's have been shown to be so much more effective than tamoxifen that that alone gives me confidence.

Does Letrozole carry the risk of side effects? Yes. But so far I am not having any side effects (nearly 100 days on it now). If I do and if they became intolerable, we have a couple more drugs we can try. My MO did take the precaution of having a bone scan and, because of those results, putting me on twice-a-year Prolia shots to reduce further bone loss (and, hopefully, build bone mass). He also put me on additional calcium and vitamin D and I consulted with his in-house nutritionist in order to fine-tune my already healthy and primarily plant-based diet.

That's where I am...I'm sure that if I'd gone with chemo I would feel just as good about my decision. My husband and I decided at the beginning of this to own our decisions and not to let "creeping doubt" enter into it.

Good luck, henry8, and keep us posted.

So Meow, you got your MRI results? Congratulations!

You’re probably right. They post my scan reports pretty quick either way. With mammagrams and ultrasounds I know before I leave. How did you get them to do an MRI every year? I want that! All I get is a CEA and mammo.

Thanks Meow, I don’t have the density problem. I was thinking you get full body MRIs to watch for mets. Not even sure if there are full body ones, now that I think of it. Do you get tumor marker tests?

In 2011 I was diagnosed with IDC, 1cm, Stage I, Grade 3, 0/2 nodes, ER+/PR+, HER2- My Onco score was 18. I was told I was on the borderline of needing chemo. I elected not to have chemo because I was stage 1 and my lymph nodes were clear. Seven years later I am still cancer free. It was recommended I take hormone suppressant meds for 10 years. I took Femara for the first three years after surgery/radiation and then Anastrozole for 2 years. I am currently taking Tamoxifen for the remaining 5 years. I have had no recurrence to date.

For me the side effects were cumulative I tried to get through the achy joints. I did the treadmill 1hr everyday religiously. One day I felt I couldn't get out of bed. Called oncologist went on different medication that caused weight gain and severe dry eye. Almost 3 years off that stuff feeling much better.