What would you do?

The Mammaprint website says that a low risk score means no chemo and that hormonal therapy may suffice. Your post was confusing on this point and just want to make that clear. Here is a quote from the site:

"if a breast cancer patient is Low Risk by MammaPrint hormonal therapy (e.g. Tamoxifen) alone may be sufficient to further reduce her recurrence risk."

Oncotype only used Tamoxifen in their studies, and it looks like the same is true for Mammaprint. Aromatase inhibitors may be more effective. In any case, Tamoxifen halves risk of recurrence in the Oncotype studies which would mean your risk would go from 7-10% to 3.5-5%. 

Only you can decide. Many people take anti-hormone meds with little trouble or manageable trouble. I have many health issues but have been on them for more than 3 years. Yeah I get stiff, so I exercise and after 20 minutes it goes away. I had pre-existing osteoporosis which has gotten worse (can't take meds) but I would rather be disabled than dead (I have kids with special needs.)  So far, no fractures.

It really is up to the individual. I would try them at least, but that's me.

One other thing: I had reactions to all the generics (two different meds), and have to take brand name Femara. I got state help for the coverage gap. This is different from side effects but is more like an allergy.

The hormonal meds are supposed to cut any residual risk in half. I guess you need to weigh the possible risks of them against the reduction of risk for BC recurrence. Make the best choice for you and try not to look back.

Some people have no or minimal SE's. Some of those SE's start right away and get better over time. Some risks of the medications occur over a long period of time. You should not be recommended to take anything if the risk to you is greater than the benefit.

I took Tamoxifen for only 3 months. I had a number of problems while on it. Most concerning were severe leg cramps that disrupted my sleep every night and a worsening mental or emotional state - which could have been related to the lack of sleep. I was still on Herceptin as well.

I worry a little, even with a great chemo response, about a recurrence. I've had a second opinion doctor also recommend Tamoxifen. So I intend to try again but will start with a really small dose (5 mg) and gradually increase it. And if I can't tolerate it or can't increase it - oh, well.

I'm of the opinion that most people should at least try what is offered after asking appropriate questions.

Thanks, but I did Magnesium, Calcium, Potassium, tonic water, hydration, leg stretches, pickle juice - basically anything and everything recommended to me.

I also quit a taxing new job and went back to my old job. And started seeing a counselor. And joined a fitness and nutrition class.

It took several weeks, like 6 or so, after quitting the Tamoxifen for things to improve.