Using DIM with an aromatase inhibitor

Dana-Farber has been really meaningful to me. And looking at the research as much as possible I do see a lot of variation in results. They are advising me that the variation makes them believe this would not be a good choice now. If I was on tamoxifen, they way they would be more comfortable. My markers have been off a bit for the first time in the last seven years but they do not see anything on my imaging yet. Dr. Block in Chicago supports mainstream approaches but does push the boundaries for complementary treatments compared to Dana-Farber. The question is where is my comfort level? At this point in my treatment we are trying to figure everything out. Wonderfully, I am living outside the boundaries. An extraordinary responder! But that means everything is not clear. Funny place to be.

Dear dtad,

Thanks for your response. Getting others experiences is valuable. I have heard of using DIM in leu of tamoxifen especially. I do get your point about being redundant. That is something I am wondering also. Again thank you for your insight. I made me think of that point again.

Dear Lilsuzq,

Dana-Farber has said that there is research with DIM might have mild estrogenic effect. So theoretically it could exacerbate hormone sensitive conditions such as breast, uterine, and ovarian cancer; endometriosis; and uterine fibroids. However, preliminary research also suggests that DIM might have antiestrogen effects and could potentially be protective against hormone-dependent cancers. So they are saying until more is known, they advise women with hormone-sensitive conditions to avoid DIM. I am on an aromatase inhibitor. Dana-Farber would be more comfortable with me taking DIM if I was on tamoxifen.

I just saw Dr. Block recently. When I call there, the staff cannot really answer this question. Dr. Block wanted me to do more things like take DIM. His oncologist said everything looked great and just basically keep up what I am doing. Dr. Block said he disagreed. Recently a staff member there said I could ask questions of Dr. Block in a phone conversation. I did not know that was an option. I am sure this will have a charge. I am kind of thinking this through. I know Block will say that there is research supporting DIM use for it's antiestrogen effects, because Dana-Farber is saying that too. I do not know if there is research looking at metastatic cancer/aromatase inhibitor/DIM use. Again, it is kind of odd being on the edge of research.

I would love to see what you think about your experience at Block. I have been going there for about 5 years. I am using them more for their nutritional advice now. The aromatase inhibitor has tanked my metabolism and dealing with my weight has been a problem. Block is actually more helpful with this for me than Dana-Farber, although my insurance will not pay for phone call conversations with the nutritionist. I am grateful for the help though. Hope your experience is good.

Wishing the best....