How are people with liver mets doing?

Hi ladies! Will be going back and reading through the posts but looks like I am joining you. Ibrance and Faslodex have quit working.

Max_Otto, yes to your question. I took verzenio in Dec. 2017. After 4 weeks, my liver enzymes jumped to over 600. Both alt and ast were very high. We stopped the verzenio, because I also got a blood clot. I started doxil, and that didn't work, so I am back on verzenio at 75 mg twice daily, 3x a week. A baby dose! But we are running out of options. Noticed this week, liver enzymes are starting to go up. So, navelbine will be next. Getting a liver biopsy next week. I am hoping we can find drugs that are not so hard on the liver.

Love hearing the good news Hartrish!

JFL, thanks for the idea of the ginger candies. I will look into those.

Therese

Celebrate_Life: you were wondering if there were any chemos not hard on the liver.

A few months ago my bilirubin levels shot up, first to 12 when <= 1 is normal. Scans showed >20 spots in my liver. My other liver markers were. I have higher than previously too. Whilst completeing radiation for my femur (ano story my femur developed a crack near the top which were caused by new bone mets and I had an emergency rod and pin were out in) My bilirubin shot up again to 16 (actually 19 when I was admitted) I had a procedure to insert a stent, however this didn't bring my bilirubin down.

According to my MO Cisplatin is the only chemo I could take with such high bilirubin. I then started it (every three weeks) and within the first dose my bilirubin leaves had come down to 2.5, and now are 1.5 in the blood tests after my second dose. I am staying on Cisplatin for a couple of more rounds. But can now take other chemos. Cisplatin is hard on the kidneys and so you take it with 2 hours of hydration before before and after the dose., takes around. Side effects are hearing loss/tinnitus. I have this slightly, thoughI don't think it's getting worse. Also - I was given all the leaflets for hair loss but don't seem to have any - my hair doesn't seem to be thinning either. I'm quite tied but no nausea due to good drugs to take alongside.

From being very ill with jaundice and scared and facing only having one option I am so relieved to back to normal for not only bilirubin but all my liver markers.

Celebrate, Thanks for your response, I'm reading about V and the impact on bibliubin and enzymes which are concerning after Y90.

Scwilly, You do have positive news, bili and enzymes are normal which should help clear the jaundice. I can identify with being scared, every time they run another MRI, I am a wreck prior to the results, I try to control this but the dark thoughts creep in.

-k

great news. Hartrish.

Max Otto - We have a dedicated abamaciclib thread where the Abamaciclib experts hang out ...

Z

Thanks Grannax! I hope I can say the same some day

I see the doctor tomorrow. Since I have morphed into triple negative, I don't see any options. I am on doxil-but I do not believe it is working. I went to the triple negative site-but quickly got off because most of these lovely women are no longer with us. I wonder if I should just quit treatment. I have no quality of life. I am scared.

lisajo. Sending you hugs and positive vibes. See your doctor and have a look at whats on the table. There has to be more options.

I have my liver biopsy tomorrow. Am pretty nervous about it.

lisajo everyone here knows I am no Pollyanna, yes, TN is tricky, but it's not a life sentence. Many ladies do well for a very long time. I can't possibly tell you medically, everything that you took is enough or you did not take enough. But i do know there are many treatments still out there. Maybe a 2nd opinion would be good for you to hear more ideas or different ones. Is that at all possible for you? Make sure you got as much info you can. Thinking of you.

Gracie I bet you will. I was the exception to the rule because of my lung mets. They had to intubate me, that's the only thing I had SE from. The BX is soo important for your TX. I wish the pathology didn't take so long to get back. Waiting is not my strong suit.

Good morning ladies. I'm kind of a passive participant on the thread. There's so much great information here but unfortunately my brain fog won't let me comprehend very much of it at one time. I have a couple of questions I'm hoping you ladies can help me with. I have extensive bone mets, a (mostly resolved) pleural effusion in my right lung, and extensive liver Mets. Of course we are focusing on the liver. I'm taking letrozole and verzenio. Two months so far on the letrozole. A little over a month on the verzenio. The only liver symptoms I had in the beginning were nausea, loss of appetite, amd dark urine. After starting letrozole, the dark urine became normal appearing very quickly. When I began the verzenio the urine became somewhat darker again and I developed mild jaundice. It went away. Then at the end of my first month of verzenio I was out of it for five days because of some mixup with the specialty pharmacy and my insurance. Ive been back on it for five days now. Today I woke up with mild jaundice in my face and moderate in my eyes. Everything else seems to be better. Any thoughts?

just got out...am in recovery. They couldn’t get to the liver, the spot is very close to an artery. So they went to the hip and got a rather large Chunk of a new lesion. Enough to store some!!

Gracie, I'm glad you're in recovery!

Gracie-Glad your biopsy is over. Hoping you recover quickly. Hugs!

Lynne