Letrozole (Femara), Fatigue and Depression.

I didn't get those symptoms until two years in. Are you still close in time to menopause? The first weeks involve a sharp drop in estrogen levels so I would wait and see. The body adjusts to that quick change, but it takes some weeks. In my experience the real problems with aromatase inhibitors come from a slower accumulation of effects form low estrogen over a period of years. But everyone is different.

Make sure you exercise!  Walking can feel difficult at first but after 20 minutes or so you start to feel better, so always walk at least 45 minutes or so. I have found Tai Chi to be helpful as well, and I am sure yoga would be too.

pabbie, I'm on the same hormone therapy track as you except I'm 46 and premenopausal so I get the added bonus of Lupron. I took Aromasin for 5 months. The last month my hands and feet ached so much I couldn't sleep. Took a five day break then started Femara three weeks ago. I loved your use of the word "blanketed" because it's true. I feel an emotional darkening happening and easily cry at anything. Today, a beautiful summer afternoon found me napping in my bed (not even outside in the gorgeous sunlight). I just couldn't hold up my head. I'm going to try to stay w this drug; I start back to my teaching job next week. I hope I have the energy for it. Hope it's true that in time for our emotions even out. Hugs.

It's usually four letters like TEVA BREC ACCO ACTA MYLA at the end of the line the word Letrozole is on

I am 1/3 through radiation and will start letrozole when I complete this part of treatment. However within the three months that I was told that I possibly have breast cancer and conclusively do you have breast cancer my triglycerides and glucose skyrocketed both more than doubled. Both along with my blood pressure had been totally non-problematic before the stress of this diagnosis hit my system. In addition my blood pressure at each doctors appointment since surgery July 5 has also skyrocketed. Obviously I am not dealing with stress very well and I'm truly not sure what I can do to get back to who I was. These numbers make me more nervous so the cycle of stress is just revolving nonstop. I realize also that I'm not necessarily dealing with breast cancer alone right now as a spot was seen on my simulation CT scan which led to a long scan which is leading to diagnostic testing to determine if perhaps I now have asthma. I can only wonder if this is also anxiety induced. I also am being tested once the long scam and testings resolve within an endoscope to determine if in fact there something awry in my esophagus. Of course this two leads to the never ending stress that I can't seem to escape. I do take pleasure after my teaching job and after radiation to take a nice walk each day with a bok in hand. I average the ten thousand steps

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I have been on Femara for 18 mths now and the last 2mths or so I am so fatigued, not just tired where a good sleep helps. I am 58 and only work 10.5 hrs a week and have to really push myself to do that. Am usually a very energetic person.

Talked to my onco and he said that it would be Femara as all my bloods are good.

I'm glad I found other people that are suffering fatigue. Thought something was wrong with me given the length if time I have been on it and very little side effects.

Thanks. 💚