Skin Deep - Youthful skin and nails while on Tamox and AI's

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  • LillyDuff
    LillyDuff Member Posts: 73
    edited April 2018

    I also had Botox for the first time last year right before diagnosis. I loved the results, but now just wonder...Botox is a toxin, so why are we putting that into our bodies? Can't anyone think of anything else for those 11's and wrinkles other than poison? (Not going back to Botox as I just wonder if it triggered "something" in my body to all of a sudden present a lump that "just popped up out of blue." Ladies, do your self breast exams-it saved my life!!!!!!!!!!!

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  • TwoHobbies
    TwoHobbies Member Posts: 2,118
    edited April 2018

    Here's a topic I love and look forward to hearing everyone's ideas. I prefer to use safe products also. Love to check them on EWG, although unfortunately they can't keep up with the industry and a lot of stuff isn't rated.

    I'll start by saying I don't have any acne problems anymore and skin is on the dry side. I'm pretty happy with the condition of my skin at 57. My annoyances are the hooding eyes, lines around my mouth, and one large brown spot that won't go away! These seem particularly hard to address. If anyone has suggestions, please let me know. I haven't done any dermatological intervention except I did trentinoin for one year.

    1. Sunscreen and hats. I currently use Australian Gold 50 sunscreen which I bought thinking its all mineral and safe, but I saw it still rates a 4 on EWG, so next time I will probably try something else. For body I use neutrogena 50 dry touch - it is all mineral and rates well on EWG. Can use for face too but it kind has an annoying texture to put on and does leave some white cast.

    I'm outdoors a lot, and if you are too, you really can't rely on just sunscreen, even a 50 that I have always used. I learned this from noticing my forehead is way better than the bottom of my neck - I have always worn a baseball cap outside which protects my upper face but not down to my neck or chest . This year I'll look for something with a wider brim.

    2. Vitamin C - this REALLY does brighten and almost right away. By day 2 I saw it. I have been using Drunk Elephant C-firma. Fairly expensive but they use safe ingredients. I love their products that I have tried - but found cheaper alternative I'll try next time (see below).

    3. The Ordinary - I use their granactive retinoid and buffet (peptides and hyalauronic acid). Inexpensive and they use no parabens, phthalates, etc. I used prescription retinol for about a year - honestly I can't tell if it was better than this retinol.

    4. Face oils - I don't use moisturizer lotion or creams anymore. Whatever base I'm putting on from above, I add 3 or 4 drops of rose hip oil (The Ordinary), argan oil or marula oil or some combo.

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  • gkbuser
    gkbuser Member Posts: 348
    edited April 2018

    I use Norwex body cloths with warm water for my skin care. Not much else: they cleanse and exfoliate with no chemicals. I can't tell you how simple and effective this is! This is not the make up removal clothes, but the actual body cloths. For day,I use Burts Bees BB cream, it has moisture, sunscreen and tint all in one. Not a lot of color choices but I use the medium. At night I use Burts Bees nightcream with royal jelly. I use blush and eyeliner from Mineral fusion. For my nails I LOVE Essie treat, love and color. I buy it at my local Walgreens. I have the "sheers to you" color. My nails have been a wreck on AI's and this has really helped the peeling. I am a minimalist on a tight budget, but these products make me feel like a million bucks! http://www.essie.com/nail-polish/color-and-care?gclid=EAIaIQobChMIi-njiu2c2gIVloTICh1QNwAcEAAYASAAEgK21fD_BwE

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  • Michelle_in_cornland
    Michelle_in_cornland Member Posts: 1,689
    edited April 2018

    GK, why are you not on Tamoxifen with hair and nail issues? I am feeling relatively unscathed, and it has been a year and two months. I had to wait until I finished radiation and had the hysterectomy/oopherectomy. I would check on the Norwex cloths, as they have some type of anti bacterial agent to prevent mold, mildew and fungus. Would a plain microfiber cloth give the same results? I, too, am very careful with soaps and wash cloths. I purchase mostly white towels and wash cloths, because I bleach them when needed. My niece is an esthetician, and uses alot of terry cloth products on her clients. She swears by bleaching and using hot water with the white cloths and towels. She also believes that the bleach used in the washer helps prevent contamination of hair follicles on the face. She has amazing skin and her clients are radiant.

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  • gkbuser
    gkbuser Member Posts: 348
    edited April 2018

    I was not a candidate for tam due to severe endometriois. And that endo was in multiple places in my abdomen. If it wasnt for that, they would have put me on tam. Norwex is antibacterial with small amounts of silver used in the material. That is why only water is needed. I also think that is why it has worked so well on my acne and refinespores. The very first time I used them, I was amazed.

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  • dtad
    dtad Member Posts: 2,323
    edited April 2018

    LillyDuff...peptides are probably the best thing for the 11's besides botox. Nothing will give you the results of botox but peptides do make a difference. Please let me know if you want any brand suggestions. Good luck.

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  • Michelle_in_cornland
    Michelle_in_cornland Member Posts: 1,689
    edited April 2018

    Getting ready for a conference this week in Vegas, "the city that sucks all the moisture from your body." Last year, I had to make an emergency run to Ulta for hair oil and rose bud salve for my lips. This year, I am prepared. I am taking several types of moisturizers, hair oil, hair conditioner, leave in hair conditioner, leave in cream.....the arsenal.

    I love anything Vitamin C, as my skin does glow with use.

    GK, do you think the silver causes a positive reaction, such as with colloidal silver, shrinking pores and preventing acne? That would make sense to me, but also concern me because of metal toxicity.

    Two hobbies, I love working with products of all kinds and testing them. Last night I used Amieka shampoo with Lanza silver shampoo, and Lanza blue conditioner with Redkin's Soft conditioner. After which, I applied Monat's leave in conditioner ..... just a bit. I am trying to keep my hair a dark ash blonde, devoid of warm tones. My hair always wants to go light and I like depth. And, in anticipation of Vegas, it was moisture, moisture, moisture on the hair.

    Dtad, as always, your opinions are appreciated and please tell us what peptides you recommend!!

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  • LillyDuff
    LillyDuff Member Posts: 73
    edited April 2018

    dtad- Just read your reply. Yes, please any recommendations would be appreciated. Thank you!:)

    Also, I have been researching PRP vampire facial as an alternative to Botox.

    PRP-platelet-rich plasma includes drawing blood from your arm, separating the platelets, and then injecting them back into you in another location where needed for skin rejuvenation via microneedling. Any thoughts out there on that one? I am really interested in trying this out as an alternative to Botox toxins.


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  • gkbuser
    gkbuser Member Posts: 348
    edited April 2018

    michelle, I absolutely think the silver makes the difference. The silver wouldnt be absorbed by the skin. Nothing is left on the skin.http://sustainablesuburbia.net/why-are-the-norwex-body-cloths-so-effective-against-acne/

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  • dtad
    dtad Member Posts: 2,323
    edited April 2018

    LillyDuff....I know Kim Kardashian does the PRP facial treatment LOL! I use Skin Care 2 products and I buy them on Joella Milan's site. Just google it. You can also Email her with any questions. I don't believe you have to buy the highest end products. On the other hand I really do not think most drugstore products work that well. IMO the key ingredients are a much lower percentage and the packaging is many times insufficient. Most important skin care ingredients break down very easily once they are exposed to air. Especially, vitamin C. So they really should not be packaged in jars. Dark colored or closed bottles are the best. PS make sure you use the coupon codes if you go on Joella's site. Every brand has a code and you get 5-6 5 dollars off/month. Good luck and let me know if you have anymore questions.

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  • LillyDuff
    LillyDuff Member Posts: 73
    edited April 2018

    dtad-Thank you for the recommendations.

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  • TwoHobbies
    TwoHobbies Member Posts: 2,118
    edited April 2018

    Michelle, how do you like the Amika shampoo? I haven't ventured into safer shampoos too much - it says they don't use phthalates and parabens, etc. What type of hair do you have -curly, straight, fine dry? When you mentioned dry Vegas, it reminded me that my favorite lip balm ever is ecolips mongo kiss, and its organic so I feel Ok about putting it on my lips.

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  • Michelle_in_cornland
    Michelle_in_cornland Member Posts: 1,689
    edited April 2018

    I do like the Amika products. Sometimes, I will use the Amika shampoo with Lanza blue conditioner/redken soft conditioner ....I like to use several products at one time, to keep my hair hydrated. I used hair oil in Vegas several times.

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  • HersheyKiss
    HersheyKiss Member Posts: 550
    edited July 2018

    WebMD recently featured a slideshow,

    The Truth About Beauty Product Dangers.

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  • gkbuser
    gkbuser Member Posts: 348
    edited October 2018

    image

    Has anyone ever tried nail wraps? I had these nail wraps that I had gotten with points from a reward store. I'm off this week so I decided to put them on last Friday and I have to say I'm pretty impressed! They're very pretty, were easy to apply (they were just a peel and stick type didn't need heat or anything or any special equipment) I'm on day 4 of Living pretty normally. Cleaning, laundry, shampooing baths, and dishes up the Wazoo and they still look great. I know that I have a lot of nail breaking and peelinissues from the anti hormonal medications and I'm guessing this could be a pretty cheap and easy way to help our nails.



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  • Michelle_in_cornland
    Michelle_in_cornland Member Posts: 1,689
    edited October 2018

    GK great idea. I have not tried them, but have been a vitamin c and calcium w/ d3 crazed person over the last several months. Even the pinky nail, that was a couple mm long, is now fine. I use a combo of Sally Harden and Butter London. I do plan to try some wraps, when I don't have my hands in Dawn, cleaning baseboards and prepping for painting.

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  • gkbuser
    gkbuser Member Posts: 348
    edited October 2018

    Michelle, I've heard Sally Hansen has a very good nail wrap. I'm going to try that brand too.

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  • gkbuser
    gkbuser Member Posts: 348
    edited November 2018

    So I have been using nail wraps pretty continuously since October 16th when I posted the picture. All I can say is nail wraps where have you been all my life! Since then I have done the color Street French manicure and loved it. Today I just change those to the Jamberry apple cider wraps which is from their Autumn collection. I'll try to post a picture. So far I have tried both the color Street and the Jamberry. Jamberry are vinyl with heat activated adhesive. Color Street are actual strips of nail polish that include the base coat color and top coat. The Jamberry company went through some changes while back and a lot of their Consultants left at that time. So, I have found a lot of things online that people are getting rid of real cheap. I've been getting sheets for around 5 to $6 on places like Facebook garage sale sites and Craigslist. If you're into Etsey there's some on there too. So price-wise can be a deal if you look. I think full price for the jamberrys are around $15 per sheet and color Street are a little cheaper at 11 to 13.

    image

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  • Michelle_in_cornland
    Michelle_in_cornland Member Posts: 1,689
    edited November 2018

    Nice, GK, I have always wondered about using something like that. I think they could protect the nail in the winter from dry air and splitting // peeling.

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  • TWills
    TWills Member Posts: 679
    edited November 2018

    I've totally changed my skincare routine and added several different things. I'm just over one year out from finishing chemo and rads and one year on Tamoxifen and recently turned 47. Skin before all of that was always very oily. It changed to very dry during treatment but is slowly changing back to oily but not completely. During and after chemo I noticed my face “fell" and lost elasticity and suppleness and I developed the 11's between my eyes and frown lines around my mouth, seemingly overnight. As if chemo and treatment wasn't enough. I'm three treatments into a series of 6 biweekly(every two weeks) microdermabrasion and light Jesners peel treatments, so far I love what it has done for my skin! I've also started using a High Frequency facial unit daily. Got it from my esthetician but they are available on Amazon for $30ish. They are amazing! I also treated myself to Dysport(BOTOX alternative) for my 11's, I've never done anything like that before so it was scary but let me tell you, it's amazing! I LOVE LOVE LOVE the results. I love the way it looks but more than that, I love the way it feels! I had no idea how much stress I carried between my eyes. I totally understand why they do these treatments for migraines. I live in an area where prices are quite competitive or it wouldn't have been something that I would have done. I got a deal from a referral and paid $110 which was about half price. Anyway, that's my update for now. I also got Retin A, but I won't start that until my microdermabrasion treatments are done. On that note, compounding pharmacy prices are amazing for things like retin A, $30 compared to $190

    Oh, and I’ve added Collagen Peptide powder, 20g added to my coffee every morning. It’s only been a few weeks and I’m not sure if I’ll be able to tell exactly what’s working for sure but I do know that my skin feels firmer from the Jessner peels.

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  • Nomaddd
    Nomaddd Member Posts: 40
    edited November 2018

    I am not super sure about using collagen powders. I also bought some but might end up not using it.


    "Disseminated breast cancer cells often enter a state of dormancy in metastatic niches, and their reactivation causes the emergence of metastatic disease even many years later. The tetraspanin TM4SF1 was previously identified as a molecule that promotes metastatic outgrowth in mice injected with dormant cancer cells. Gao et al. found that TM4SF1 promotes the reactivation of dormant breast cancer cells in the lung, bone, and brain by facilitating signaling in response to cellular contact with type I collagen, a major component of the extracellular matrix (ECM). Bioinformatics analyses showed that high TM4SF1 expression correlated with reduced metastasis-free survival in breast cancer patients and that expression of a TM4SF1-associated gene signature (identified in TM4SF1-transfected cells) was a predictive marker of early relapse. Silencing TM4SF1 in metastatic breast cancer cell lines both decreased the expression of various pluripotency factors, including Sox2, a signal transducer and activator of transcription 3 (STAT3) target gene. When injected into mice, breast cancer cells in which TMS4SF1 was knocked down exhibited less metastatic outgrowth in lung, bone, and brain without impairing tumor cell viability. Staining lung sections from a mouse model of metastatic breast cancer to detect collagen and Ki-67, an indicator of actively dividing cells, indicated that most tumor cells in contact with type I collagen were proliferating, whereas most of those not in contact with type I collagen were not positive for Ki-67, suggesting that these may be quiescent. Treating cultured breast cancer cells with soluble type I collagen but not other ECM components induced wild-type but not TM4SF1-deficient cells to form tumor spheres. Various analyses revealed that TM4SF1 interacted with the extracellular portion of the collagen receptor discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase, and stimulated collagen-induced clustering of DDR1. The TM4SF1-DDR1 complex interacted with the scaffold protein syntenin 2. Silencing TM4SF1 prevented the coimmunoprecipitation of DDR1 and syntenin 2. Time course analyses after treating dormant breast cancer cell line 4TO7 with type I collagen while manipulating the abundance or activity of various proteins revealed that collagen-stimulated DDR1 activates protein kinase Cα (PKCα) through TM4SF1, which recruits PKCα through syntenin 2, and that PKCα subsequently activates Janus kinase 2 (JAK2)–STAT3 signaling. Silencing STAT3, SOX2, or syntenin 2; disrupting syntenin 2 binding to TM4SF1; or silencing but not enzymatically inhibiting DDR1 suppressed the ability of breast cancer cells to form organoids in culture or colonize metastatic niches in mice. Given that the presence of type I collagen stimulates cell migration out of the primary tumor, these new findings reveal another mechanism by which this ECM component promotes metastatic disease.

    H. Gao, G. Chakraborty, Z. Zhang, I. Akalay, M. Gadiya, Y. Gao, S. Sinha, J. Hu, C. Jiang, M. Akram, E. Brogi, B. Leitinger, F. G. Giancotti, Multi-organ site metastatic reactivation mediated by non-canonical discoidin domain receptor 1 signaling. Cell 166, 47–62 (2016)

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