Drug interaction question....

I am not on Tamoxifen or an anti-depressant, but have seen this topic come up over the time I have been on this site. Here is a pretty comprehensive list of the many drugs that interact with Tamoxifen. Anti-depressants, and Benadryl, are the most frequently discussed here on BCO. Here is the link:

https://www.drugs.com/drug-interactions/tamoxifen-index.html

teacher- I felt like that when I first started Tamoxifen. I called it “medicine head” to my husband, and I wasn’t taking any other meds. A little bit like having a little too much to drink. I was taking mine right before bed, so it kinda helped me sleep back then. It did go away after a month or so. Hope this helps!

My head felt that way too on tamoxifen. It eventually progressed to brain fog where i literally felt like I was walking around in a fog and would forget what i was doing/saying, what i was planning to do/say, words would just fail me right in the middle of a sentence, recall was greatly affected (I'm in medical sales so this was not a good thing at all) and i even had issues knowing where i was at times. One afternoon on the way home from work I really thought I was completely lost as the exit I take off the highway didn't look at all familiar. I started to panic because I truly had no idea where i was. Thankfully another part of brain was taking me home by rote. I eventually figured out where I was but it was VERY scary on so many levels. I don't tell you this to scare you, rather to give you things to watch out for. If these start to happen definitely reach out to your MO to check into alternatives to tamox therapy.

I agree with moth. A pharmacist is your best bet!