CONFUSED - HAS THIS HAPPENED TO ANYONE

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Hope2018
Hope2018 Member Posts: 45
edited March 2018 in IDC (Invasive Ductal Carcinoma)

I was recently diagnosed with IDC.  Biopsy showed 90% ER positive, PR negative, HER2 negative.

Small 0.8cm tumor.

After lumpectomy path report showed triple negative.  Margins clear - Sentinel node negative.  How can you be 90% ER positive on biopsy and TRIPLE NEGATIVE on lumpectomy path report

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  • taylorlaurie
    taylorlaurie Member Posts: 3
    edited March 2018

    Hello,

    I was first diagnosed with TN in 2009. Mastectomy and chemo. 9 years later (3 weeks ago) i was diagnosed with TN again but in my remaining good breast. My reports have always agreed so I don't know what is up with yours. I know if your original cancer metastasizes it can change to a different typ but i don't understand this change for you. Of course, the best person to ask is your oncologist but in the meantime you might also join the Triple Negative Breast Cancer Foundation forums where all of us have TN diagnosis's. Someone there might have heard of this before. My user name there is Cheeks.

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  • moth
    moth Member Posts: 4,800
    edited March 2018

    I have been messaging Hope privately but just wanted to say here too that yes, this happened to me and it was explained to me that tumors are not always heterogeneous. It could be a smooth consistent tumor like a plain vanilla cake or something like a mixed fruit pie where depending which chunk you grab, you'll get different results.

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  • taylorlaurie
    taylorlaurie Member Posts: 3
    edited March 2018

    Thats great I’m glad you’re talking to her.

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  • NotVeryBrave
    NotVeryBrave Member Posts: 1,287
    edited March 2018

    The pie analogy makes sense. You might also consider getting a second pathology report done through another lab to see if it agrees. Some major centers have such programs pretty easily available.


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  • Hope2018
    Hope2018 Member Posts: 45
    edited March 2018

    That makes sense.  It's bad enough we have what we have.  Now we have to deal with conflicting info and who knows there is so much that can go wrong in the process of preparing and testing our tissue that error are made and some of us may be getting chemo that may not need it.  What do you think?

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  • NotVeryBrave
    NotVeryBrave Member Posts: 1,287
    edited March 2018

    Since there are many risks with chemo - I don't think I'd do it without confirmation by another pathology lab. And possibly a second opinion from oncology.


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  • Hope2018
    Hope2018 Member Posts: 45
    edited March 2018

    Thanks for your reply.  I'm requesting the slides from the core biopsy and it makes sense to have another evaluation before the chemo journey.  There is so much that can go wrong with the preparation and testing of these tissues.  We all want to make sure that we are doing the right thing.  

    I appreciate your response and I hope you are doing better with your treatment.  

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