Clinical vs Genomic

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Larissa714
Larissa714 Member Posts: 5
edited February 2018 in Chemotherapy - Before, During, and After

Has anyone had a high clinical risk but very low genomic? My mammoprint says no benefit from chemo and I've already had one cycle of a.c. and was extremely neutropenic and lost most of my hair today. Waiting on more tests from Sloan. Everything I've read says genomic is accurate and much of clinical is based on interpretation from pathologist( ki67 etc...) my reoccurance rate with tamoxifen is less than 3 percent. 10 percent with no treatment at all. I'm so conflicted. My head is spinning!!

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  • Murfy
    Murfy Member Posts: 342
    edited January 2018

    Hi Larissa! It is my impression that any nodal involvement means chemo is indicated, regardless of genotype and genetic tests. Positive node could mean metastasis, even as remote a possibility as that may be for you. The bottom line is that YOU have a choice in the matter regarding your own treatment!

    I, too, am conflicted. My cancer was small and contained, but Oncotype test said highest risk...so I learned today that I am supposed to have chemo too. I haven't decided yet if I want to go that route because I am predisposed to harsh and possibly irreversible side effects. Still doing my research...

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  • gb2115
    gb2115 Member Posts: 1,894
    edited January 2018

    I was high clinical risk but low genomic risk via mammaprint. I did not receive chemo on the advice of my oncologist.

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  • Hopeful82014
    Hopeful82014 Member Posts: 3,480
    edited January 2018

    No, nodal involvement does NOT automatically signal that chemotherapy is indicated.

    Nodal involvement does indicate that recommendations and decisions may need to be more nuanced.

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  • carmstr835
    carmstr835 Member Posts: 388
    edited January 2018

    My MO suggested no chemo for me as well. He stated only a 3% benefit with chemo. Onca score was 17 and 19. Mammaprint was low. I had 2 lymphnodes positive and extra nodal as well as Her2+. I went for a 2nd opinion and my case was brought before a tumor board and it as decided that I should have TCHP. My 2nd opinion MO puts little value in the Onca scores. HEBelieves it doesn't account for heterogenous tumors that he believes I have,

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  • Irene1524
    Irene1524 Member Posts: 7
    edited February 2018

    Waiting for my Mammaprint result. My sentinel lymph node had a 5.5mm metastatic tumor in it, but I was also advised that node positive does not necessarily mean chemo. My doctor said chemo does not work very well against Grade 1 cancers, because they are too similar to normal cells.

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