Forgetfulness

Hi avidreader, treatments for BC like chemo and horomone suppressors put our bodies into a menapausal like state. That is why we have short term memory issues. Long before my cancer diagnosis I started peri-menpause. The first noticeble symptom was that memory loss. I would go into meetings with parents and draw a blank on names. It was very embarrassing and frustrating because I had always had an exceptional memory, especially for names. Good news is once the body goes into full menopause a lot of the memory gets better. Now mind you...I'm not talking like it was when you were 20, but the blanks become fewer. For now, use whatever helps you compensate. It does get better.

This is the side effect that bothers me the most with Chemo. I had such a great memory, but more than that a great vocabulary. Now I use the wrong words all the time and it is truly discouraging. If I didn’t make lists, I’d remember nothing! Sometimes I don’t even know what day it is. I really hope this is temporary

"Chemo brain" has been the most frustrating side effect for me (and I'm post-menopause, so that had nothing to do with it for me). I have to make lists and set reminders in my phone for everything. Sometimes I have to "think through" ordinary tasks, or even say the steps out loud. Called the doctor to make an appointment one day and couldn't even remember my own telephone number. I hope it's only temporary, but apparently it can be a long term problem for some people and that worries me.

Brain Health

Study Suggests Eating Salad May Improve Brain Health

20 Dec 2017

http://n.neurology.org/content/early/2017/12/20/WNL.0000000000004815

Search words: brain fog, memory, brain health, memory loss, eating for brain health, cognitive decline, improve your memory

Abstract

Objective To increase understanding of the biological mechanisms underlying the association, we investigated the individual relations to cognitive decline of the primary nutrients and bioactives in green leafy vegetables, including vitamin K (phylloquinone), lutein, β-carotene, nitrate, folate, kaempferol, and α-tocopherol.

Methods This was a prospective study of 960 participants of the Memory and Aging Project, ages 58–99 years, who completed a food frequency questionnaire and had ≥2 cognitive assessments over a mean 4.7 years.

Results In a linear mixed model adjusted for age, sex, education, participation in cognitive activities, physical activities, smoking, and seafood and alcohol consumption, consumption of green leafy vegetables was associated with slower cognitive decline; the decline rate for those in the highest quintile of intake (median 1.3 servings/d) was slower by β = 0.05 standardized units (p = 0.0001) or the equivalent of being 11 years younger in age. Higher intakes of each of the nutrients and bioactives except β-carotene were individually associated with slower cognitive decline. In the adjusted models, the rates for the highest vs the lowest quintiles of intake were β = 0.02, p = 0.002 for phylloquinone; β = 0.04, p = 0.002 for lutein; β = 0.05, p < 0.001 for folate; β = 0.03, p = 0.02 for α-tocopherol; β = 0.04, p = 0.002 for nitrate; β = 0.04, p = 0.003 for kaempferol; and β = 0.02, p = 0.08 for β-carotene.

Conclusions Consumption of approximately 1 serving per day of green leafy vegetables and foods rich in phylloquinone, lutein, nitrate, folate, α-tocopherol, and kaempferol may help to slow cognitive decline with aging.

Citations

Nutrients and bioactives in green leafy vegetables and cognitive decline

Authors: Martha Clare Morris, Yamin Wang, Lisa L. Barnes, David A. Bennett, Bess Dawson-Hughes, Sarah L. Booth

Neurology Dec 2017, 10.1212/WNL.0000000000004815; DOI: 10.1212/WNL.0000000000004815

Brain Health

Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study

19 Sep 2017

http://onlinelibrary.wiley.com/doi/10.1002/cncr.30987/abstract

Authors: Sheri J. Hartman PhD, Sandahl H. Nelson MS, Emily Myers MPH, Loki Natarajan PhD, Dorothy D. Sears PhD, Barton W. Palmer PhD, Lauren S. Weiner BA, Barbara A. Parker MD, Ruth E. Patterson PhD

The study was funded by the National Cancer Institute of the National Institutes of Health. The authors have disclosed no relevant financial relationships.

Search words: brain fog, memory, brain health, memory loss, eating for brain health, cognitive decline, improve your memory, memory and motion, exercise

Abstract

BACKGROUND

Increasing physical activity can improve cognition in healthy and cognitively impaired adults; however, the benefits for cancer survivors are unknown. The current study examined a 12-week physical activity intervention, compared with a control condition, on objective and self-reported cognition among breast cancer survivors.

METHODS

Sedentary breast cancer survivors were randomized to an exercise arm (n = 43) or a control arm (n = 44). At baseline and at 12 weeks, objective cognition was measured with the National Institutes of Health Cognitive Toolbox, and self-reported cognition using the Patient-Reported Outcomes Measurement Information System scales. Linear mixed-effects regression models tested intervention effects for changes in cognition scores.

RESULTS

On average, participants (n = 87) were aged 57 years (standard deviation, 10.4 years) and were 2.5 years (standard deviation, 1.3 years) post surgery. Scores on the Oral Symbol Digit subscale (a measure of processing speed) evidenced differential improvement in the exercise arm versus the control arm (b = 2.01; P < .05). The between-group differences in improvement on self-reported cognition were not statistically significant but were suggestive of potential group differences. Time since surgery moderated the correlation, and participants who were ≤2 years post surgery had a significantly greater improvement in Oral Symbol Digit score (exercise vs control (b = 4.00; P < .01), but no significant improvement was observed in patients who were >2 years postsurgery (b = −1.19; P = .40). A significant dose response was observed with greater increased physical activity associated with objective and self-reported cognition in the exercise arm.

CONCLUSIONS

The exercise intervention significantly improved processing speed, but only among those who had been diagnosed with breast cancer within the past 2 years. Slowed processing speed can have substantial implications for independent functioning, supporting the potential importance of early implementation of an exercise intervention among patients with breast cancer.

Cancer 2018; 124:192-202. © 2017 American Cancer Society

I have only had one lot of chemo so far...EC and I have already noticed its affected my memory. However, prior to BC and chemo I had already developed an altered memory due to severe Anaphylaxis. Each time I have a shock I stop breathing and my heart stops briefly, which obviously starves the brain of oxygen and therefore a very altered memory. I am 33 and its quite bad. It has already deteriorated with chemo. I am taking Magnesium and now Rosemary Oil as I have extensively researched these and found them to be beneficial to memory loss. However not a cure. Before my diagnosis I finally decided to just accept my memory loss and learn to adapt and have things in place to help with certain important things I was forgetting.

I guess my only recommendation is to do the same, accept and learn to adapt. Sorry if that sounds heartless, I sincerely don't mean it such way.

Cancer Recovery – Nutrition

Top 12 Cancer-Fighting Foods

https://draxe.com/cancer-fighting-foods/

Leafy Green Vegetables

Leafy greens are the cornerstone of any healthy diet since they're exceptionally rich in vitamins, minerals, antioxidants and enzymes, yet very low in calories, fats, sodium and other toxins. Leafy greens of all kinds — nutritious spinach, kale, collard greens, romaine, arugula salad, watercress, etc. — are rich in antioxidants known to combat cancer, including vitamin C and beta-carotene (a type of vitamin A).

And the benefits keep coming; as natural sources of glucosinolates, they also contain antibacterial and antiviral properties, inactivate carcinogens, help reprogram cancer cells to die off, and prevent tumor formation and metastasis. These powerhouse chemicals are known to break down during the chewing and digestion process into biologically active compounds that prevent cancer cells growth, which are referred to as indoles, thiocyanates and isothiocyanates.

Isothiocyanates (ITCs) found in leafy greens, which are made from glucosinolates, have been reported to help detox your body at the cellular level. Add a handful of leafy greens to your lunch and dinner to increase your nutrient intake; to make obtaining them simpler, try juicing vegetables for near perfect health. Vegetable juices are very easy to digest and make yourself at home. The Gerson diet meal plan even advises cancer patients to drink 13 glasses of freshly prepared juice daily!

Cruciferous Vegetables

Cruciferous vegetables are known to be powerful cancer killers and some of the best vitamin C foods widely available. Many are rich in glutathione, known as the body's "master antioxidant" since it has high free-radical-scavenging abilities. Nearly all members of the brassica family of cruciferous vegetables are nutrient-dense sources of a family of phytochemicals called isothiocyanates that are linked to cancer prevention. In addition to isothiocyanates, cruciferous veggies like cabbage and broccoli also contain sulforaphanes and indoles — two types of strong antioxidants and stimulators of detoxifying enzymes that protect the structure of DNA.

Add one or two kinds — including broccoli, cauliflower, cabbage or Brussels sprouts — to three mostly plant-based meals daily in the form of roasted veggies, soups or stir fries, or dip them into hummus or Greek yogurt for a healthy, fast snack. Additionally, many other vegetables are beneficial for lowering cancer risk, including onions, zucchini, asparagus, artichokes, peppers, carrots and beets.

Berries

The ORAC scores of nearly all berries are very high, making them some of the top high-antioxidant foods in the world. Blueberries, raspberries, cherries, strawberries, goji berries, camu camu and blackberries are easy to find and use in numerous types of recipes — which is good news considering they supply vitamin C, vitamin A and gallic acid, a powerful antifungal/antiviral agent that increases immunity.

Berries are especially rich in proanthocyanidin antioxidants, which have been observed to have anti-aging properties in several animal studies and are capable of lowering free radical damage. High amounts of phenols, zeaxanthin, lycopene, cryptoxanthin, lutein and polysaccharides are other berry benefits. Less familiar "superfoods" mulberry, camu camu and goji berries have been used in traditional Chinese medicine since around 200 B.C. to increase immunity and energy, so look for those in powder or dried form in health food stores and online.

Brightly Orange-Colored Fruits and Veggies (Citrus Fruits, Squash, Sweet Potatoes, etc.)

Brightly colored pigments found in plant foods are a sure sign that they're beaming with phytochemicals, especially carotenoid antioxidants. This is exactly the reason you want to "eat the rainbow" and vary the colors of the foods on your plate.

Carotenoids (alpha-carotene, beta-carotene, lycopene, lutein, cryptoxanthin) are derivatives of vitamin A found in many citrus fruits, sweet potatoes, berries, pumpkin, squashes and other plant foods. (14) One of the most researched is beta-carotene, an essential nutrient for immune functioning; detoxification; liver health; and fighting cancers of the skin, eyes and organs. Two nutrients that give these foods their signature dark hues include lutein and zeaxanthin, which have been shown to help prevent eye and skin-related disorders since they act as antioxidants that filter harmful high-energy blue wavelengths, protecting healthy cells in the process.

When it comes to carbohydrate-rich veggies, studies show that complex carbs, including sweet potatoes, carrots, beets, other tubers and whole-grain foods, is related to a reduced risk of several types of cancer, particularly of the upper digestive tract. This is likely due to a favorable role of fiber, but the issue is still open to discussion. In contrast, refined grain intake and high glycemic load foods are not apart of an anti-cancer diet. These have been associated with increased risk of different types of cancer, including breast and colorectal. (15)

Fresh Herbs and Spices

Turmeric, which contains the active ingredient curcumin, is one of the most powerful ingredients in an anti-cancer diet because it's been shown to decrease tumor size and fight colon and breast cancer. Along with easy-to-use black pepper, turmeric absorption is enhanced and better able to fight inflammation. Aim for one teaspoon of turmeric powder and 1/4 teaspoon of black pepper or more daily, which can easily be used in a tonic drink, with eggs or in a veggie stir fry. You can also take curcumin supplements; aim for 1,000 milligrams daily.

Additionally, other herbs that act as immune system boosters include ginger, raw garlic, thyme, cayenne pepper, oregano, basil and parsley — which can easily be used in many recipes, juices, dressings and smoothies.

Organic Meats

Organic meats including beef or chicken liver are recommended on many cancer-fighting diets since they're considered some of the most nutrient-dense foods on the planet and extremely high in vitamin B12. Consuming organic meats as part of a "nose to tail" approach to eating animal proteins provides minerals that help cleanse the liver and enhance the ability to remove toxins from the blood and digestive tract.

Detoxifying with rich sources of selenium, zinc and B vitamins helps purify blood; produce the bile needed to digest fats; balance hormones naturally; and store essential vitamins, minerals and iron. These mineral-rich foods can help counteract the effects of alcohol, prescription drugs, hormone disruptions, high triglyceride levels, low potassium, obesity and viral infections.

Cultured Dairy Products

Cultured dairy products are a rich source of "good bacteria" probiotics, which are microorganisms that promote a natural bacterial balance in your intestinal microflora and help increase immunity. Over 80 percent of your immune system is housed in your gut, so it's no surprise that probiotic foods and supplementation can stop tumor growth and help cells renew.

One of the easiest ways to consume more probiotics is in their most natural state, which includes raw milk products such as cheese, kefir and yogurt. Raw and cultured are key here, since fermentation produces probiotics but high heat processing used to pasteurize dairy can damage many of the vital nutrients, including the enzymes, proteins and probiotics. Most dairy today is loaded with hormones, antibiotics, pain killers and pesticide residue so buying organic is also important.

Aim for six ounces of cultured dairy daily (probiotic yogurt, cottage cheese, goat milk kefir or amasai). Cottage cheese, which is rich in sulfur protein and saturated fats, was found to be especially beneficial as part of the Budwig diet for cancer protocol. You can also increase your probiotic food intake without dairy by consuming cultured vegetables like kimchi, sauerkraut, coconut kefir, kombucha or natto.

Cultured dairy is also a great source of calcium. Calcium, particularly when combined with Vitamin D3 form, may reduce the incidence of cancer by 35 to 60 percent. Calcium seems to be especially beneficial for preventing cancer and rectal cancers. (16) Some studies have also found that it helps reduce breast cancer and ovarian cancer risk. Sunlight exposure and marine oils such as cod liver oil or krill oil are great sources of vitamin D that help with calcium absorption. Calcium should ideally be obtained from foods like organic dairy products (I recommend

Nuts and Seeds

Chia seeds and flaxseeds are two of the most nutrient-dense seeds in the world. They provide fiber, omega-3 fatty acids and a range of important minerals. Hemp seeds, sesame seeds, pumpkin seeds and sunflower seeds are also beneficial and full of healthy fatty acids, as are walnuts, brazil nuts and almonds. Their health benefits and are best sprouted and can be used easily in smoothies, baked goods and with yogurt. Aim for two tablespoons daily.

Healthy Unrefined Oils (Coconut, Flax, Cod Liver and Extra Virgin Olive Oil)

Did you know that your brain and nervous system control the function of your entire body and that about 60 percent of your nervous system is made up of fatty acids? The problem is that many of the conventional processed fats and oils widely consumed today are hydrogenated oils that are capable of destroying the membranes of our cells, leading to diseased cells and toxicity.

Refined and rancid fats create problems throughout your entire body, leading to lower immune function, cell congestion and inflammation that kicks off disease. Replace refined vegetable oils, hydrogenated oils and trans fats with quality oils, including flax oil, extra virgin olive oil, cod oil and coconut oil. These nourish your gut and promote better immune function, help you reach and maintain a healthy weight, plus flaxseed and cod liver oil contain essential omega-3 fatty acids that can help energize your cells. Olive oil contains phytonutrients that seem to reduce inflammation in the body. It may reduce the risk of breast and colorectal cancers.

Mushrooms

Nutritious mushrooms vary in terms of their benefits, taste and appearance since hundreds of mushroom species are in existence today, but all are known to be immune-enhancers and many have been used to fight cancer for centuries.(17) Reishi, cordyceps and maitake in particular can improve immune function, fight tumor growth and help with cell regeneration. Look for them in capsule or tincture form, and cook with them whole whenever possible too.

Traditional Teas

Metastasis is the most deadly aspect of cancer and results from several connected processes including cell proliferation, angiogenesis, cell adhesion, migration and invasion into the surrounding tissue. Metastasis is the principal cause of death among cancer patients, so it's one of the most important issues in cancer research today. Several clinical and epidemiological studies have reported that the consumption of green tea can help decrease cancer risk. Green tea contains major polyphenolic compounds, including epigallocatechin-3-gallate, which has been shown to inhibit tumor invasion and angiogenesis, which are essential for tumor growth and metastasis. (18)

Teas derived from the leaves of the plant Camellia sinensis are commonly consumed as beverages around the world, including green, black or oolong tea. While all traditional teas seem to be beneficial, the most significant effects on human health have been attributed to green tea, such as matcha green tea. It contains the highest percetange of polyphenolic compounds, catechin, gallocatechin and EGCG.

The antioxidant EGCG appears to be the most potent of all the catechins, and its anticancer effects have activity about 25–100 times more effective than that of vitamins C and E! EGCG has been reported to be linked to the modulation of multiple signaling pathways, finally resulting in the downregulation of expression of proteins involved in the invasiveness of cancer cells.

Wild-Caught Fish

According to a 2004 study conducted by researchers at the Richerche Institute of Pharmacology, higher fish consumption is another favorable diet indicator of better immune function. (19) The study, which investigated the cancer-fighting effects of the Mediterranean diet, found that people who reported eating less fish and more frequent red meat showed several common neoplasms in their blood that suggested higher susceptibility.

Wild and especially small fish, including salmon, mackerel and sardines are anti-inflammatory omega-3 foods that are correlated with better brain, hormonal and nervous system health. Omega-3 fatty acids exert anti-inflammatory effects, and therefore recent studies have connected them to cancer prevention and natural enhancement of anti-tumour therapies. (20) Evidence suggests a role for omega-3 fatty acid supplementation in cancer prevention and reducing symptoms of treatments like chemotherapy. Omega-3s have been shown to preserve muscle mass and function in chemotherapy cancer patients and to contribute to a reduced inflammatory response resulting from the treatment's toxicity.

I have been on Arimidex since end of June and I also have memory problems. Very frustrating but Iguess we all just have to deal with it.

Discovering Curcumin's Brain Benefits

To read more on the benefits of Curcumin, select the link:

http://www.lifeextension.com/Magazine/2017/SS/Discovering-Curcumins-Brain-Benefits/Page-01

Cognition, memory, spatial orientation, facial recognition, learning—all depend on intact brain structure and function.

We've seen that curcumin's ability to combat inflammation and oxidative stress makes it a powerful ally for our brain health. A 2017 study uncovered another mechanism behind curcumin's neuroprotective and cognition-enhancing properties: It promotes brain-cell plasticity.¹²

Neuronal plasticity is the degree to which connections between individual brain cells (neurons) can be made, broken, and remade rapidly.⁷⁰ This allows us to stay in touch with the constant changes in environment, knowledge, and emotions. The ability to make these connections quickly—thousands of times faster than the fastest computer—is what underlies learning, memory, and cognition.

A major factor in supporting neuronal plasticity is the ability to produce neurites, which are tiny projections emanating from brain cells.^71-73 Neurites form branches called dendrites, which connect our neurons. It is via these synaptic connections where nerve signals are transmitted.

Preclinical experiments have demonstrated impaired neurite outgrowth in models of neurodegenerative disease, depression, and stroke. This lack of ability to form connections between brain cells contributes substantially to impaired plasticity—and ultimately to weakened cognition, memory, and learning skills.^74-79

This new knowledge about improving connectivity between brain cells is what makes curcumin so attractive to researchers.

Curcumin promotes vigorous neurite outgrowth and enhances neuronal plasticity.^12,80-87 Even more encouraging is the fact that in these studies, curcumin administration resulted in the formation of new brain cells. This effect improved memory and increased cognitive function.^12,84

These effects have been shown to counteract – and even reverse – the harmful effects of chronic stress and even brain injury on cognition, memory, learning, and plasticity.^85,87

How It Works

Curcumin's remarkable ability to enhance neurite outgrowth (and therefore, neuronal plasticity), comes from its ability to regulate a unique biochemical signaling molecule called brain-derived neurotrophic factor (BDNF).^12-16

BDNF promotes neurite outgrowth, promotes brain-cell survival, and boosts synaptic plasticity—all of which help to build and maintain the neuronal circuits that let us learn, think, and remember.^88,89 In essence, it's what allows us to exist as individual humans.

It was only in late 2016 and early 2017 that scientists began to appreciate how powerfully curcumin promotes production and activation of BDNF in brain tissue.^12-16

Piecing these studies together gives us a nearly-complete picture of how curcumin produces dramatic neuroprotective effects that contribute to improvements in age-related brain disorders.

Curcumin's unique ability to upregulate BDNF secretion results in greater neurite outgrowth and, subsequently, improved brain plasticity—the very connections that are necessary to preserve cognition and memory.

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