Help for a diagnose explanation!

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herder033
herder033 Member Posts: 7
edited December 2017 in Just Diagnosed

Hi, I ask you kindly somebody translate me this path results. Thank you!

Sectorectomy piece 5/4, 5 / 2,5 cm, marked and oriented, with 4.5 / 1.7 cm cutaneous flap. 
On the section, a yellowish grayish tumor formation with undefined undefined areas measuring 1.2 / 1.1 cm 
is found and is 2.5 cm from the posterior edge, 2 cm from the median margin, 1.5 cm from the lateral, 0.3 cm 
from the top, 0.5 cm from the lower one. The tumor form retracts the adjacent skin. 
To the lower one there is an increased whiteness of 0.5 cm in diameter. 
Microscopy: 
The sections examined from the tumor model macroscopically depicted in the left sectorectomy piece exhibit 
malignant tumor proliferation of the type NST invasive breast carcinoma grade Nottingham I (tube 2, nuclear 2, 
mitotic grade 1, total = 5) that associates a the in situ intermediate ductal carcinoma component with solid 
or cribriform architecture, occupying approx. 15% of the tumor surface. 
Tumor proliferation extends to the dermis without affecting the epidermis, infiltrates adipose tissue and 
neighboring muscle tissue, shows desmoplastic reaction, extensive areas of hyalinization and low lymphocyte 
infiltration. 
Calcifications have been identified in the Invasive Breast Cancer Carcinoma component as well as in 
outbreaks of ductal carcinoma in situ. 
The closest resection margin is the upper one, which is at 2 mm from tumor proliferation. 
The ductal ductal carcinoma in situ is 7 mm below the lower edge. 
Observed lymphatic tumor emboli and appearance of perineural invasion. 
At the level of the parenchyma in the proximity of the lesion, typical ductal epithelial hyperplasia, 
adipose necrosis are identified, and corresponding broad areas of increased consistency are described 
macroscopically, extensive areas of hyalinization are present. 
Conclusions: NST invasive breast carcinoma with grade Nottingham I
pT1c Nx Mx L1 V0 R0 Pn1
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Comments

  • Mucki1991
    Mucki1991 Member Posts: 294
    edited December 2017

    Hi there I'm sorry you find yourself going through this. NST means no special type a low Nottingham score means they do not think it's a very aggressive cancer. When you speak with your DR take notes or have someone go with you as it's a lot of information to take in.

    Best Wishes for you.

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  • herder033
    herder033 Member Posts: 7
    edited December 2017

    Many thanks for your kind replay:-)

    This is my first encounter with such a diagnosis. I read a lot about this problem but I don't really know how to understand such a plenty of information. I made an effort to translate into English all this. I want to know what I have to expect next: treatment, prognosis, recurrence? The chemotherapy will be recommend. My first meeting with an oncologist will be in 8'th of January, when I'm scheduled. It seems doctors not hurry; this is a good sign I suppose. :-) Best wishes from snowy Europe!

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  • bluepearl
    bluepearl Member Posts: 961
    edited December 2017

    You have a grade 1 tumour that looks to be about 1.2 cm. It also appears you have lymphatic invasion and perineurial invasion (there is nerve tissue and lymphatic vessels in the tumour) and you have muscle infiltration,,,which lightly would have chemo recommend. It doesn't state the hormonal status nor her2, nor lymph node status. Those have yet to be discovered. Pt1c indicates it is, at the moment, stage 1. You have non-invasive DCIS present (common) and calcium deposits (common). If you have positive hormones and negative Her2 they may do a oncotypeDX on you, a genetic assay to determine if chemo will be necessary (usually grade 1 tumours don't respond well to chemo). If you decide mastectomy, you may want to consider radiation to that area because of the muscle infiltration issue. Actually, I am not a doctor but from I have read in journals, radiation would be highly recommended. Hope this helps a bit. (((HUGS))))

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  • herder033
    herder033 Member Posts: 7
    edited December 2017

    Thank you bluepearl,

    I have HER2 negative

    ER-70%

    PR-100%

    KI67-10%

    Nodes does not revealed because the radio tracer goes into my breast tiny node not to the axillary lymph node.

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  • herder033
    herder033 Member Posts: 7
    edited December 2017

    no one want to help me!

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  • Georgia1
    Georgia1 Member Posts: 1,321
    edited December 2017

    Hi there herder. We are not medical professionals, but your prognosis looks fairly good to me. The tumor is small and not very aggressive or fast growing. The low Ki67 score is also good. And the high ER and PR numbers mean the cancer should be treated well with tamoxifen or a drug called an AI, a daily pill. I suspect your oncologist will discuss surgical options with you (lumpectomy vs masectomy) then perhaps radiation.

    I wish you all the very best. Because of Christmas many people will not be online today.

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  • muska
    muska Member Posts: 1,195
    edited December 2017

    Dear Herder, i am sorry you have been diagnosed with breast cancer. Bluepearl and Georgia gave you an explanation of your path report above. With regards to treatment you need to discuss it with your Medical Oncologist and other specialists. Depending on your age, overall health and other specifics of your case they might recommend chemo, radiation and hormonal treatment or some combination thereof.

    Best of luck to you and keep us posted!

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  • herder033
    herder033 Member Posts: 7
    edited December 2017

    thank you very much, georgia1, i had already the sectorectomy, and in january i will start the radio therapy. somebody can tell me how many radio sessions will receive in my condition? TKS

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  • herder033
    herder033 Member Posts: 7
    edited December 2017

    Thank you muska! I'm 51 and i will start the radio in January. I curious how many radio session will i receive. Thank you

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  • HollyDollyD
    HollyDollyD Member Posts: 77
    edited December 2017

    Hey herder033...

    It's a lot to take in. Really. And I do a lot of research for my job - and it is STILL a lot to take in. I found this website helpful in explaining the terms:

    https://www.cancer.org/treatment/understanding-you...

    (((HUGS)))

    Holly

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  • SavedbyGrace1972
    SavedbyGrace1972 Member Posts: 105
    edited December 2017

    Herder033

    I'm sorry you have joined this club. Not sure what the igination process was or who was in charge of the selection process, but here we are. The women and men on this board are helpful. They've read a lot, researched a lot and experienced a lot. But everyone's cancer is different so the treatment will be different as well. I suggest you write down questions in a notebook for your medical team. After all, we are paying them and they should at least answer our questions.

    Good luck to you. Good luck to us all and may God be with us!

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  • Georgia1
    Georgia1 Member Posts: 1,321
    edited December 2017

    Hi Herder. In the US, the standard course of radiation is to the whole breast, daily for five to seven weeks. In Canada I believe it is usually three weeks + then four days of more targeted radiation to the tumor site.

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  • herder033
    herder033 Member Posts: 7
    edited December 2017

    Thank you, i am thankful for each response you provide me. I am confident in the capacity of my body to be healthy again, as well in the oncologist which i will meet in a few days, and in my Almighty God! I wish you a happy new year with health and happiness to all of us . :-))

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