Create FileSee comment in PubMed Commons belowSci Rep. 2016 Jan 27;6:19771. doi: 10.1038/srep19771.

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production.

Leoncikas V¹, Wu H¹, Ward LT², Kierzek AM¹, Plant NJ¹.

Author information

1

School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.

2

Oncology DMPK, AstraZeneca, Alderley Park, Cheshire, SK10 4TG, United Kingdom.

Abstract

A major roadblock in the effective treatment of cancers is their heterogeneity, whereby multiple molecular landscapes are classified as a single disease. To explore the contribution of cellular metabolism to cancer heterogeneity, we analyse the Metabric dataset, a landmark genomic and transcriptomic study of 2,000 individual breast tumours, in the context of the human genome-scale metabolic network. We create personalized metabolic landscapes for each tumour by exploring sets of active reactions that satisfy constraints derived from human biochemistry and maximize congruency with the Metabric transcriptome data. Classification of the personalized landscapes derived from 997 tumour samples within the Metabric discovery dataset reveals a novel poor prognosis cluster, reproducible in the 995-sample validation dataset. We experimentally follow mechanistic hypotheses resulting from the computational study and establish that active serotonin production is a major metabolic feature of the poor prognosis group. These data support the reconsideration of concomitant serotonin-specific uptake inhibitors treatment during breast cancer chemotherapy.

PMID:

26813959

PMCID:

PMC4728432

DOI:

10.1038/srep19771

[Indexed for MEDLINE]

Free PMC Article

Marijen very interesting article. I think I'll ask my mo about it.good news. My alnd was negative for anymore positive nodes!

marijen, surprisingly my platelets were normal at end of chemo darn it! not sure what they were prior to chemo; however did get a blood clot around picc so I'm thinking they weren't low at any point! hope the chemo and the upcoming tamoxifin will help destroy any other circulating (or at this point no longer circulating) cells

very interesting video and some info a little above me but it does explain why cancer patients are at risk for deep vein thrombosis and pulmonary embolisms

Jay, I didn’t have much pains prior BC, now I have pains on my knees. I need to move it around in the morning, if I sit for long time, I feel the pains on my knees also. That’s all I can say.

Moving around is the best thing for aches. Of course, if you overdo it, that can make you sore/achy too. The rule of thumb for anything (except, of course, you are in agony, running a high fever or something acute, is to wait two weeks before you even start to think about checking with a doctor. Jay, I would be willing to bet it's from your unaccustomed trips up & down the steps carrying heavy loads.

Hi ladies

Thanks for your thoughts, and responses. It made me feel better, but my mind still goes to "what if it's this"? Can't help it. I feel like I'm always going to have this dark cloud over my head. Still having the aches in the joints, but today, it eased off a little.

ruthbru

My mother, as well thinks it's my trips up and down the stairs, also in heels, no less. It's funny you mentioned two weeks, and I already had an appointment with my onco on the 18th. Didn't realize it until I looked at my calendar today.

PauletteK

I never had any accute pains before breast cancer as well, so this just scares me some. I will feel better when I see my onc.

bravepoint

I wish I could get up early, maybe I need to trade in my two cats for a dog. Lol. My daughter and I love animals. She would love another cat, and a dog. One of our cats acts more like a dog. She runs out every chance she gets. What breed are your dogs?

Oh, to those of you who have pets, have at anytime they got on your lap, and laid their paw on your chest? My cat does this to me every time I sit on the couch, or lay in bed. This has been going on since my diagnosis. I believe our beloved pets just know their owners.

marijen

Love that, move it to lub it. I have to ask, what is synovial fluid? Never heard of it.

Hey PauletteK






My pain was better today, however, last night was awful. I'm at my mother's house which is two hours away from mine. So, I had to pack in a hurry, always pack too much. I'm on the second level of my complex, so many trips up and down the stairs carrying luggage. My ex-husband always did that. I miss being married, however we get along great. He has been right there for me through my journey, and we've been divorced for four years. Thank you so much for asking. So many wonderful women on this forum. I can gaurentee your dog knows exactly what's going on with you. They are very smart, and perceptive. I've read stories where women who have a dog, or cat gave them signals that something was wrong before they were diagnosed. What would we do without our pets???? On another note, how are you doing? You're supposed to be starting radiation this month. When do you start?

🤦♀️🤦♀️🤦♀️

JaymeB - I have 3 German Shorthaired Pointers, Terra 15 1/2 years, Dante 4 years and Rayne 9 years. They are very high energy so need that walk/run every morning! They were a huge comfort to me during my year of surgery then chemo then rads. Whenever I lay down to rest, they snuggled in tight beside me.

Hope99 - Sounds like you are doing chemo before surgery. I did surgery first. The stage of your 2A or B refers partially to the size and lymph node involvement. The grade tells you how aggressive the tumor is growing. Good luck with your chemo. Drink lots of water and rest when you need to!

hello Gail,

you are right, chemo first then surgery, this is what the doctor said, he told me I gave you 6 cycles due to nodes involved, two nodes according to biopsy,US and mammogram. how they know by biopsy? I don't know how!

hello legomaster,

how you find a positive node through biospy and nevgative after surgery?! strange, do you mean the chemo kills cancers in nodes and tumour? appreciate your respond dear.

no Gail, my biopsy not taken during surgery, the doctor used very thin needle to take that biopsy in 15 min . after one week, oncologist doctor told me you have two positive nodes!

BOTH, FIRTS THEY TOOK FROM LUMP AFTER THAT THEY TOOK FROM AUXILIARY NODE

jaymeb, no apologies necessary. It's a lot of people to keep track of.

moth - A fellow Canadian and a dog lover! Awesome! Dogs are my thing too. I used to have horses as well but it's easier to take the dogs to competitions than it was to take the horses. I do a lot of agility with my 2 younger dogs and teach it as well. It kept me going last winter when i was going through months of chemo. I have done just about every dog sport there is but now with less energy agility is my focus. I have always had multiple dogs and they exercise each other somewhat when they play. Maybe not the time doe you to get a puppy but there are lots of pointing dogs needing rescued in Canada. Ther is a rescue devoted to them if you want i can dig up the link.

I just looked at your stats. Pretty similar to mine though I see you are newly diagnosed. Feel free to ask any questions.

Hope, yes, had biopsy of my lymph node last December. a marker was placed at that time. In June, after chemo that node was one of 4 removed. It had no cancer in it upon removal. The chemo did kill the cancer. The goal for ore adjuvant comes chemo was to clean up the lymph node and reduce the tumor. It was very effective. My cancer on that side was 23%ER/10%PR so I think that helped the response. It was Grade 2, Stage IIB.

The pathology report identified a 3.5cm tumor bed but very sparse living cancer cells remaining. It is kind of comforting to know that the chemo worked well which I guessis one advantage of having chemo prior to surgery.