Ki-67 question-don't know where to post this

Just chiming in to agree with Special K. The Ki-67 is roughly correlated with cell growth and the Oncotype DX test will be a more informative number that includes the Ki-67 plus other genetic tests. My Ki-67 score increased from pre-surgery biopsy to post-surgery pathology, and it bugged the heck out of me since it was the only number that got worse. Typical of me to focus on the negative! But my doctor said the lack of node involvement and the smaller size was much more important so yeah, I agree with your doctors on this being happy news.

Hi Mudd. Sounds like if you are started on letrozole you are done with surgery, have clean margins and no lymph node involvement, and have already met with a medical oncologist at least once. Do I have that right? The Ki-67 score is roughly correlated with the Oncotype DX score, but please, please try not to worry while you wait for the results. Chemotherapy will be a choice you can make once you have all the facts; it is not something you will be forced to do. So far you have received mostly good news!

The Ki-67 is used a LOT as a marker in research - you'll see references to it in many studies. The problem is that it's difficult to know what standards different labs are using, so many MOs think of it as unreliable. As a rough measure of the growth rate, however, it's a pretty good ballpark indicator.

But as far as Oncotype goes, it is just one of several proteins factored in. It's pretty difficult (impossible) to guess one's Oncotype in advance so it's best to just take some deep breaths and try not to worry too much.

My Ki-67 came in post-lumpectomy patholoigy report - 56.8%. After research and speaking with surgeon, Ki-67 is correlated somewhat with oncotype dx. IF one or the other (Ki-67 or oncotype dx) is "high" (greater than 25), there is a greater than 90% chance that the other will be high, too. My oncotype dx was requested on thursday 8/2/18 and am now waiting 2 weeks for results. I am preparing myself to have to do chemo. 56.8% is a pretty damn high Ki-67. The high Ki-67 puts in the Luminal B category, which has 7 to 9 % improved overall survival rates with BOTH endocrine therapy and chemotherapy.