Anyone being treated with Abraxane after reacting to Taxol?

I had to switch to abraxane due to a reaction to an ingredient in taxol called cremophore. heres my understanding: paclitaxel is not water soluable so the cremophore is used to dissolve the paclitaxel. A lot of people who have reactions to taxol are having a reaction to the cremophore. Abraxane is paclitaxel without the cremophore. They use protein from blood instead of the cremophore whichbinds to the paclitaxel. I didn't need steroids or Benadryl with abraxane making the infusion time much shorter. Needless to say, I had less SE's from Abraxane. Hope this helps:)

In 2012 I had 3 infusions of Taxol and developed a severe rash, Aftwas switched to Abraxane but the rash still continued. The rash cleared up a few weeks after I finished Abraxane.

I had severe reactions to taxotere and taxol, so we switched to Abraxane. So far, I've had no issues aside from the minor bone/joint pain on day 5 after the infusion in my case. I do still have the premed though, after the previous reactions, my MO didn't want to take any chances.

Michela802,

I have Abraxane weekly and have the premeds given slowly, since the steroid can make me feel odd, then the Abraxane itself is a 1/2 hour. The SE's are similar to taxol but of course everyone has a different experience. Hair loss, taste buds, neuropathy in the hands and lifting fingernails have been really annoying but tolerable.

Yes, 1st was taxotere, BP dropped to 60/61 w/abdominal and back pain, heat, flushing and severe shaking. Two weeks later I tried taxol, BP jumped to 176/112 w/intense back pain, puking, heat and flushing. Abraxane was such a relief and has been working very well.

TWG, are you still going to have premeds on Abraxane?

I do. I had bad allergy reaction to taxetera after two rounds of TC infusion: hives head to toe. My doctor replaced Taxetero with Abraxane for then 3rd infusion which I had 10 days ago. The new cocktail worked well on meso far. Less foggy brain, no bad allergy