Triple Positive and Lupron?

Hi all!

I'm almost 6 years out from diagnosis of Triple Positive Stage 2a node negative. I just got my period back last week..after almost 6 years. I went to the Gyno who did a sonogram to confirm that is what it was, and it was for sure my period. Now my oncologist wants to meet with me about pros and cons of Lupron + Tamoxifen.

I REALLLLLLLLLLLLLLLLLLLLLY do not want to do Lupron but am I going to have a choice? This is literally my first period and first ovulation since October of 2011. Shouldn't we wait and see if I get another one?

Would love some thoughts?

Thanks!

Thank you for responding! Do you mind me asking your age? I am 40. I was 34 at diagnosis. I also really do not want my ovaries removed.

I have been in peri menopause all this time (yearly hormonal testing has shown this) but I guess my ovaries decided to kick on this last month...who knows if they will again.

Melster,

I do monthly Lupron so I can take an AI due to the aforementioned SOFT/TEXT trial results...I was 31 at diagnosis and am 34 now. Aside from some fatigue and general blahhh for about 2 days after the shot, I don't have many problems with it. I get occasional mild hot flashes but they don't bug me too much (I know some people get them really bad though). You could always try the shots and see if you tolerate them...if you don't, you can talk to your onc about other routes. I know most oncs don't want to take ovaries out too young due to the bone risks and other issues.

I'd talk to your oncologist regarding what they think about waiting a bit to see if your period is really coming back for good.

Melster- I'm so sorry to hear that you are feeling better and that you might then have to upset your system w Lupron! I have been alternating with monthly or three month shots for various reasons. So either can be administered. I've had so many surgeries this year I didn't want another to remove my ovaries. So here we are on monthly Lupron so I can take an AI. But Ovarian suppression plus Tamoxifen was not found to be effective. Edited to add the link

http://www.ascopost.com/issues/june-10-2016/ovarian-suppression-in-premenopausal-women-with-estrogen-receptor-positive-breast-cancer/

Melster,

While the HER2 component is definitely a priority for treatment, the HR-positive factor must not be overlooked, so yes I believe the anti-hormonals are still very very important in preventing recurrence. In other words, having all the HER2 treatments in the world won't mean that you can comfortably forgo hormonal treatments, as this is another important element of your cancer. Of course, your oncologist can probably give you more info on this, but that's what I've come to understand.

Hi there

We have almost indentical stats except I was 42 when diagnosed 48 now

I did OS when my period returned. On and off for 4 or so years because I felt terrible in full out menopause. Tried several AIs and I couldn't tolerate any. So I've been on tam for 6 years with mostly suppressed ovaries

My Onc said that all the SOFT studies followed woman who did AI + OS immediately after treatment. She said they can summize that there would be a benefit for those of us a few years out but that the % benefit is unknown. Hope that makes sense. She said based in the fact that I'm tolerating tam, am at year 6 and was miserable on Lupron she is happy with me continuing on tam (they rather you in something then quitting altogether) It's been over a year since I stopped the shots and no period. I'm thinking of being tested and trying an AI again but I'm closer to natural menopause then you are

You could try the Lupron and see how you feel. That's the good thing, you can test drive menopause. You can stop if you can't tolerate i

That's good news Melster! Thanks for the update.