What about Cannabis Oil?

I live in a state where medical MJ is legal. Most of the time it's prescribed for se's, pain and to stimulate appetite. I do think there's potential for it to play a greater role in cancer so I hope the research continues.

Caryn

Yes, there is a lot of buzz around cannabis oil and it's hard to decide what's good and bad info.  I read the good stories, but I also know of people that it has been ineffective for.  I am undecided on this.  I also can't afford to treat with this.  I live in a state where it is legal for medical purposes, but insurance does not cover.  I estimated it would cost me between $500-$800 a month to use the oil.  I'd sell my car and all my stuff if There was reliable info showing me that it could work....at least some stats.  For now, I have a treatment that has been shown to be effective for some patients in my position, so that's how I reason it.

I would love to see any information from reliable sources.  Please share.  I'm still on the fence with this one.  Thanks for bringing it up, Musiclover.

ML, thanks for starting this thread.  I've also seen quite a few positive reports about cannabis oil and wondered if there's any scientific basis to them.  Here's one of the few bits of research I could find:

http://www.sciencedaily.com/releases/2014/07/14071...

And here's some interesting research on hempseed oil, which I gather has similarities to cannabis oil?  Someone on the Bone Mets thread has reported significant pain relief using a topical application of hempseed oil mixed in coconut oil, although I don't know the ratio for her concoction.

http://www.sciencedaily.com/releases/2014/01/1401...

a close friend insists I try it ..

I definitely will not have cannabis oil shots! ))

Weird presention, not to be sent to a regularly stuck-by-needles people

Zavrovka and stagefree,

It's been 2 weeks taking 15mg per day of FECO (Full Extract Cannibis Oil) with a ratio of 2-1 (CBD -THC).  A ratio of higher CBD to THC is recommended for those with estrogen receptor cancer.  I'm still looking into research and data that is appropriate and not hearsay.  It's difficult.  I'm keeping a journal, too.  DO NOT SMOKE MJ thinking you are killing cancer cells.  This only alleviates stress, eating probs, sleep, etc.

This was posted via the Susan G. Komen site.  It is a report by a cancer doctor who had been following a 9 yr survivor of Stage iv BC.  This was posted on ScienceBasedMedicine.org.

"Another thing that needs to be pointed out. Every single one of the studies invoked by Medical Jane has nothing to do with hemp oil, be it Rick Simpson’s hemp oil or some other type. Each of the studies examines either purified cannabinoids or, in the case of this study, a chemically modified cannabinoid. This study cited in Molecular Cancer, for instance, looks Δ9-tetrahydrocannabinol, the most abundant and potent cannabinoid in marijuana, and JWH-133, a non-psychotropic CB2 receptor-selective agonist. Both inhibit the growth of HER2(+) breast cancer cells in cell culture and in mice, but the concentrations needed are pretty high, with an IC50 (concentration that is 50% of maximum inhibition) in the range of 5 to 10 μM, concentrations achievable with injection of purified compound but certainly not by smoking pot

You are also unlikely to achieve these levels by drinking hemp oil, which, by the way, usually contains so little THC that it is below the limit of detection for common assays and manufacturers brag that it’s impossible to fail a drug test if you’re consuming hemp seed oil because “THC levels in our products are barely measurable.” Of course, I do realize that Rick Simpson calls his oil hemp oil even though it’s really cannabis oil derived from the buds rather than the seeds, but even he brags that “following the dosage previously described, many people can take the full treatment and never get high,” which implies that his oil achieves nowhere near the concentration of THC in the blood necessary to be active against cancer. Moreover, oral bioavailability of THC from such oils is notoriously low, between 4-20%, making it unlikely that concentrations well above the 10 μM necessary to inhibit or kill more than 50% of the cancer cells are achievable with oral dosing.

Thus, the various studies cited, such as this one, which shows inhibition of the epidermal growth factor pathway by purified cannabidiol (CBD), a non-psychotropic cannabinoid; this one, the aforementioned study that examines purified Δ⁹-THC and JWH-133 against HER2(+) breast cancer; and this one, which also examines CBD in breast cancer, are interesting and very preliminary. Moreover, they all examine cannabinoids purified from cannabis, and one even examines a chemically modified cannabinoid. In other words, even if cannabinoids make the jump from preclinical models to humans, these studies do not support the use of medical marijuana, either smoked as the plant or ingested as an oil, to treat breast cancer. They also do not suggest sufficient activity to produce miracle cures of stage IV cancer as described by Rick Simpson. Indeed, a recent review concludes that “current preclinical data does not yet provide robust evidence that systemically administered Δ⁹-THC will be useful for the curative treatment of cancer,” although CBD might have a role based on preclinical data."

All stats are preliminary in finding and we must try to push forward for more definitive studies and verified evidence for a federally registered Cannibis Oil so that controlled access is no longer a struggle for those in desperate need.

LaurenG - thank you for the update. How are you doing?

I am taking 10mg per day of CBD/THC in a 4:1 mixture. Probably well below any therapeutic dose. I am not pursuing cannabis oil as a cure right now but I have my eye on it.

>Z<

Thank you Christa! Many people will be interested in hearing how this goes.

>Z<

My wife just started oral CBD oil 1 mg per day for a few days just to make sure she isn't allergic because she is very sensitive to treatments. For the past 3 days she took 25 mg per day (powder in capsule) with no noticeable immediate effect. I'm hoping to get through a month maybe increasing to 50 mg per day during the last week or so. She's also on warfarin so we are closely monitoring her INR. Apparently the CBD may affect the metabolism of other drugs so please be aware of this aspect (Google it).

dx 2002

metastatic 2004: liver, bone

too many treatments to list

current Kadcyla, cycle 2 for recurrence after 5 month "vacation"

I will be starting Ibrance and Letrezole at the end of the month. I am currently using CBD(in pill form) - so far it has helped with anxiety, pain and my appetite. I heard that CBD can interact with Ibrance though - has anyone's doctor discussed this? I really want to continue with the CBD but don't want it to compromise the effect of the Ibrance. Thanks for your help!!

Hi! I've been reading alot about this topic with interest. I was diagnosed with ER+/PR+/HER2- metastatic breast cancer in Feb 2015 and I'm on my first line treatment (Tamoxifen & Lupron). I'm interested in medical marijuana to mitigate bone pain. (Technically, one of my two tumors in my spine sits on my spinal nerve.) I'm a little confused as there seems to be mixed opinions.

My questions to you are: (1) What is the appropriate ratio of THC:CBD given that I'm ER+/PR+/HER2-? I've read repeatedly that 1:1 or 1:3 is recommended. (2) Should I stick with a low concentration? I'm a little nervous about interactions with Tamoxifen.