Taxotere damage to hands and feet
I am going through my 4th cancer over the past 20 years and just had my 4th treatment with carboplatin and taxotere and herceptin. I started getting tender really red areas on the webs of my thumbs and forefingers that grew to cover about one half of my hands. My feet were next with very red, sore, itchy areas starting on my insoles then extending to the soles of my feet. I am especially concerned about my feet because I already have diabetic neuropathy in the soles of my feet and it is not clear to me how much improvement I will see from this....
When my Doc's nurse saw my feet, she said, "That is a Taxotere overdose". I was in tears by then and asked if I could take a week off - which is where I am now - 4 days into a 7 day break. I am a bit less red and sore but I still have two major treatments to go to finish my treatments. There are options.... I can take much smaller amounts over a longer time (a treatment a week over 9 weeks rather than two large treatments like I have been getting or I can stop right here - which does not seem smart to me at all.
I am pretty frustrated with my Doctor. I mostly saw his nurse but did he think I was just a whiner? Why did it have to get to be such an obvious overdose before any action was taken at all? He told me they "shoot for the middle when it came to amounts and length of treatments - some folks need more - some need less but they try to hit the middle patient." I experienced extreme diarrhea, vomiting, headaches, fatigue. I have been through these similar treatments on two other occasions and was chalking it up to the fact that my last chemo treatments were 13 years ago and maybe I was just feeling it more cause I am older...
I will post a followup to let yaw'll know how things are going...
Comments
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Scarlett1 - sounds like you have hand-foot syndrome. I had that after my 4th round of Adriamycin and it ran on into my first round of Taxol. My MO did decrease my Taxol dosage. Some things she told me to do that helped greatly - stay off of feet as much as possible until pain is better, keep feet elevated as much as possible, when on feet wear soft shoes with padding, ice to feet - I used bags of frozen peas wrapped in a washcloth, keep feet moisturized. It improved after abt 3 days. It was painful - so sorry you are having to deal with this. One more thing - I also iced my hands and feet while I was receiving the chemo. It will help with neuropathy.
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Scarlett1 - sounds like you have hand-foot syndrome. I had that after my 4th round of Adriamycin and it ran on into my first round of Taxol. My MO did decrease my Taxol dosage. Some things she told me to do that helped greatly - stay off of feet as much as possible until pain is better, keep feet elevated as much as possible, when on feet wear soft shoes with padding, ice to feet - I used bags of frozen peas, keep feet moisturized. It improved after abt 3 days. It was painful - so sorry you are having to deal with this.
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I had one round of taxotere. I immediately had a severe reaction to it. After 4 rounds of A/C. It was so bad MO stopped further chemo. They put some extra fluid in me, and sent me home. I think I should have gone to hospital. Worst of the whole treatment year.
I too am diabetic and had just a little neuropathy in my feet. No big deal there. The allergic reaction has affected my feet, lower legs, a very small bit in my hands. It's a strange feeling. I can feel if I've stepped on something but they always feel like wrapped in plastic wrap.
Icing wasn't heard of 5 years ago, maybe it would help prevent for you now. Press your MO for better relief. Be aware of worsening symptoms.
Good luck.
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maybe decrease the taxotere dose for the remaining cycles
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I kept telling MO that I had extreme burning in my hands and feet after first dose of taxotere. It was ignored until I took a photo in. My dose was not reduced instead was given more steroids oh and some cream that did nothing.....now am stuck with major pain 5 months post chemo hands, arms, legs, feet and torso
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Summer and scarlett,
That sounds terrible! I am on taxotere, and while I have had a little skin peeling, mostly on my feet, it is nothing compared to what you are describing. I keep body butter on my feet at all times with socks over them, and that has helped. At night I do the same to my hands and sleep with cotton gloves on.
I get it once every three weeks, and am in the middle of my second cycle. My dose is described as 75 mg/M squared/ dose in 0.9% saline 250ml, in a 60 minute infusion, for comparison to see if you are getting more than that (not that everyone is supposed to get the same thing, of course). And I would think special considerations are needed for patients with diabetes.
Scarlett, I really hope things are better and you are able to give an update soon.
L.
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Yep. I looked like that from the soles of my feet to the top of my bald head. It was awfu
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Thanks for all the moral support. Dr decided to end my chemo after 4 treatments. My Dr who does my colostomys gave me some samples of Metanx which worked wonders! After 1 pill - pain in feet and hands was gone. I still have the "walking on plastic" feeling that I had before Taxotere but at least there is no more pain. I will see about a prescription but am not sure I can get one as I believe it is classified as a "medical food" and will not be covered. I still have inflammation to both feet but I can now walk around with no problems. Good luck with your treatments - Be Well
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Thanks for all the moral support. Dr decided to end my chemo after 4 treatments. My Dr who does my colonoscopies gave me some samples of Metanx which worked wonders! After 1 pill - pain in feet and hands was gone. I still have the "walking on plastic" feeling that I had before Taxotere but at least there is no more pain. I will see about a prescription but am not sure I can get one as I believe it is classified as a "medical food" and will not be covered. I still have inflammation to both feet but I can now walk around with no problems. Good luck with your treatments - Be Well
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Scarlett1-----So good to hear there was something you could take to feel better! My doctor tested my b12 and had me start daily b12 injections, then weekly, next will be monthly. I should ask about Metanx. Trying to remember if she said that my body can't absorb through stomach that's why injections.....hmmmm will need to ask her.
Soopkiesmom----that sounds like the worst reaction yet! I'm sorry you had to endure that as I know how miserable I was with my feet and hands. Now my legs and forearms are so tight they feel like they could burst rather than stretch. My feet are horribly painful and my hands are asleep and painful yet my MO still tells me it is not the Taxotere. Well I sure wasn't like this Before Taxotere!!!! I now understand when people speak of Quality of Life. I have a few good days and many days that I can not move!
Wishing all of us wellness always!
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Summer - I hope you don't mind my jumping in but I just got back from an appointment with my neurologist to discuss my pre-existing peripheral neuropathy before starting chemo and he said that the nerve pain from chemo is the worst kind of neuropathy and usually doesn't go away completely. I was supposed to have Taxol but it and the other taxanes, like Taxotere, are known causes of what you are describing. It amazes me that doctors deny this when it is drug websites
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Hi Lita19901----Glad you joined in! Did you skip chemo altogether?
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I am 5 years out from Taxotere, and sorry to say I still have crippling neuropathy in my feet. I cannot wear closed toed shoes, def no heels, ever, and cannot stand on my feet for very long.
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I am so sorry to hear of your long suffering... I mentioned a medication above, Metanx that works wonders for me as long as I take it every day. I am running out of samples and the doc who gave me samples says my internist or a neuropathist will have to prescribe it so I will try to fit in another doc appt next week...
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I am 3 years out and worst of the neuropathy is now down to fingertips and ends of my toes. It took all of this time to get passed numb hands and feet,always dropping things. My feet still are very heavy feeling. But I hope I have given some hope that it may improve.
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