Faslodex Girls Thread 2014

So need some insight. I have been on a roller coaster since this whole thing started. I switched MO's because I felt the first one let my tx wait too long. Long Story. New MO.....I have been on Arimirdex since Feb. Started Radiation 6 days ago, RO said stop Horomone Therapy. I went to MO office today to see if he wants to see me since I am on break from Hormone, he said I should be taking it..**Shaking head*** and he wants to give Faslodex injection tomorrow....I am lucking and thanking stars, god, universe, thru this who ordeal no SE and I feel GREAT.

What can I expect tomorrow for this injection?

Shetland pony- you are always in my

Thank you, Dianarose. Ditto.

So first Faslodex today, not too bad. Feel the glass at wine at lunch will help

Shetland pony I am a little in disbelief myself when I read your disappointing news. I m so sorry to hear it. It made me realize even when we re doing well on Fas, an increase in TM could happen to any one of us, at any time and throw our treatment lives into emotional chaos all over again.

Take care and yes take all the time you need and perhaps get a second opinion. . It s not just the cancer we have to deal with . It s the damn side effects from the cancer drugs.

Hugs to you my friend!

Hugs to you Shetland Pony ...

Tell yourself It s okay to do little or nothing for a few days. Give yourself time ... pls keep us Fas gals updated on how things go ..

Hugs Shetland Pony, you are in my prayers and it's ok to want some sense of control, that is me also! We all love you! MCK54: I ended up in hospital 5 nights so very weak with acute viral syndrome possible pneumonia, I don't think they were quite sure, got IV antibiotics and still on oral antibiotics! Quite depressed, they are going to start me on Wellbutrin! I will bounce back, I know but I'm not a very patient person ,anybody have experience with Wellbutrin? Love you all!

girlwithacurl: that is such a very cute remark I love it!!my last shot was ok but the two before that I had huge glimpses and still have remnants of the

Welcome, Gardener-20! We're sorry that you need to be here but happy to have you among us under the circumstances and ready to help.

I have just completed my 5th course of Ibrance + Faslodex. I have not experienced any real side effects, to include a lack of urine odor issues and no increased appetite. No thinning of hair, either, at least so far.

My TMs are of no use, as they remain very low, regardless. They have been 7 and 15, so my onc says that they are useless as a tool.

So glad to hear about your garden gate...I'm a gardener, too! My bone mets (only ones so far) were also found by accident through a CT scan of my chest for something else, which was negative for the original offender. But...there were the unexpected mets, after 26 years from my original diagnosis.

My garden this past April (before the last 2 weeks of extreme heat). Enjoy your garden!

Hi. I just read many of your comments. I had three Faslodex and am now getting it once a month. Xgeva now every 3 months. Not so much trouble with shots per se. But very tired and grumpy for 3 days but can't sleep like when you get prednisone. I did have taste changes, urine smell. Back spasms and spasms in intestines. Lot of trips to the bathroom. Slight nausea and no appetite. Today is two weeks since my last shot. Still achy and arthritis is flaring. I appreciate reading all your comments. It helps to know that these symptoms aren't all in my head. When docs and NPs discount your symptoms it doesn't help. My last bout 11 years ago taught me that busy professionals don't always pay attention. But I remember one nurses aide, Eileen who crushed ice into tiny chips and gave them to me when I couldn't swallow. An IV was going but I was so uncomfortable I couldn't talk. I remember her kindness. She saw me and figured out what I needed. She's retired now but I'll never forget her and how she saw me as a person that day

Thank you all for you insights into this drug. Hope I stay on it for a long time

How much Claritin do you take? I take it sometimes for seasonal allergies. Does it help with side effects.

Thank you Joyner, I'll give it a try. I see you had a long time from your first go around until mets. I was Her+ and was among the first to take that. New drugs and all on this thread are a blessing

Wow, no one's posted on this thread since August! I hope that indicates all members of the Fanny Pack are cheerfully saluting the world with bottoms up.

Here's some interesting information on the development of oral SERDS. I copied this squib from a more extensive article in today's Medscape entitled "Emerging Therapeutic Strategies in Breast Cancer." Authored by Kayla Cox, BS; Brandon Alford, BS; Hatem Soliman, MD, South Med J. 2017;110(10):632-637.

Selective ER Downregulators

Selective ER downregulators (SERDs) are useful in the treatment of advanced ER-positive breast cancer that has progressed on selective ER modulators such as tamoxifen. Like selective ER modulators, SERDs competitively bind to the ER, but do so with 100 times greater affinity.^[28] In addition, SERDs stimulate ER breakdown and degradation.^[29] This strategy may be particularly useful in tumors that have acquired constitutively activating mutations in the ER gene–leading signaling event in the absence of estrogen binding.^[30,31] Fulvestrant is an intramuscular SERD approved as monotherapy in 2002 for HR-positive metastatic breast cancer in patients who have progressed on antiestrogen therapy.^[32,33] RAD1901 and GDC-0810 are two oral SERDs that are in clinical development.

RAD1901 is a novel oral SERD that may have greater clinical efficacy than fulvestrant. Like fulvestrant, RAD1901 targets ER[alpha] and promotes its degradation. In xenograft models RAD1901 demonstrated a greater antitumor effect and earlier onset than tamoxifen and fulvestrant.^[34] RAD1901 is in a phase 1 dose-escalation study for postmenopausal women with advanced ER-positive, HER2-negative breast cancer (NCT02338349).

GDC-0810 selectively binds and degrades ER[alpha] and has shown activity in tamoxifen-sensitive and tamoxifen-resistant tumor models.^[35] GDC-0810 is being compared with fulvestrant in postmenopausal patients with metastatic ER-positive/HER2-negative breast cancers that are resistant to aromatase inhibitors (NCT02569801). The oral SERDs are an attractive new developmental target because of their ease of administration and ability to escalate the dose compared with the intramuscular administration of fulvestrant.

Tina

Aurora,

It appears that all of these new, would-be alternatives to Faslodex are are still in trials.They're not available yet. We'll see if they work out!

Tina