Arimidex-Memory Loss

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  • bevin
    bevin Member Posts: 1,902
    edited February 2013

    I have trouble too and I'm young.  It is scary and I worry about long term effects too. I'm never sure if its the arimidex, or the stress coupled with lack of sleep.  Either way, I'm not liking the path I'm headed down. I wonder if there are any natural type things we can take for memory?

  • Curlylocks
    Curlylocks Member Posts: 1,060
    edited February 2013

    I am a 7.5 year bc survivor.  I took Armidex for 5 years...absolutely hated some of the s/e's...memory loss (huge), sleep distriburances, hotflashes!  I have been done Armidex for 2 years now and my memory is 100 times better, hotflashes have gone to almost nothing (I am 48 - 49 in May) but into chemical menopause at age 42 and then permanently at age 44.

    I truely believe the lack of estrogen causes the memory loss of which Armidex contributes to greatly.

    Hang in there those that are still in the trenches taking Armidex, thinks do get better after you come off the drug!

    Michele

  • signalfire
    signalfire Member Posts: 3
    edited March 2013


    Something that might help for memory loss and that 'tip of the tongue' feeling; check with your doctors but it shouldn't be an issue and get some over the counter lecithin; it has choline in it and it's the precursor for acetylcholine, one of the neurotransmitters in the brain directly responsible for that awake, alert feeling. Try one first thing in the morning and if you think you need more, try two.  If you take them in the evening you'll have trouble sleeping, just like if you'd had some caffeine.  They really do help and should not cause any side effects with your meds at all.  

    You could also add extra choline sources to your diet; I think egg yolk is the strongest one, but personally, I get sick of eating eggs all the time and would rather take the pills. 

  • ConcernedMale
    ConcernedMale Member Posts: 1
    edited March 2013

    My wife was prescribed Arimidex for 5 years after her radiation treatments for BC. She had immediate memory issues and I tried to convince her to talk to her Dr. about it. I even made a point to remind her about talking to the Dr. before an appointment and she forgot. She came back saying her bone density was good. When I asked her about how the discussion on memory loss went I got a blank stare and she said she forgot.

    I finally got her off Arimidex at 3.5 years, 30 pound weight gain and some unbelievably ridiculous conversations where she wasn't connected to what was going on. The truly sad part is that 5 years later she can't shed the weight and more sadly she still has memory loss and gets spacey. Anything critical I have to follow behind to make sure it's done. She is now 60. I'm very concerned if it might be early signs of dementia or Alzheimers at this point.

    While I'm sure it's a good medicine for some it's definitely not a cure-all for everyone. The side effects don't go away for everyone so beware and be diligent. 

  • Mountain_Gem
    Mountain_Gem Member Posts: 26
    edited April 2013

    I know this is an old post, but I wanted to ask if you've found out more about your wife's conditon. I'm going thru the same thing, but I believe at almost 64 and already with some memory loss that I need to get off this stuff. I think it must be the estrogen loss. After menopause is bad enough, but to completely wipe it out of your body isn't natural.

    I hope you get your wife checked out for dementia because there are some drugs that they say really help slow it down. I was reading on a UK Alzheimer's site where there are several people who are having real success with them, including a man who was diagnosed 7 yrs ago.

  • SandraM
    SandraM Member Posts: 1
    edited December 2014


    Hi.  I started taking Arimidex (Anastrozole) in February 2010.  This was following a lumpectomy and lymph node removal. I was 63 at the time and had been on HRT for several years.  I went from extra oestrogen (HRT) to no oestrogen in less than 3 months!  I've been OK with the Arimidex, but after about 18 months / 2 years I started to notice memory loss.  It's not too bad - I can still function perfectly normally - it's just that I forget things that were said to me 5 minutes previously!

    My question is to anyone who has been on Arimidex, has noticed the memory loss, but has now finished taking Arimidex. 
    Q: what happened to your memory after the Arimidex cleared from your system?  Did it come back? If so, how soon?

    I'd really appreciate hearing from anyone out there.  Thanks.

  • Moderators
    Moderators Member Posts: 25,912
    edited December 2014

    Hi Sandra,

    This topic is a bit old, but still very relevant.

    There has been some research showing that certain treatments can affect memory.

    Take a look here:

    Memory loss

    Based on this, it appears that the memory issues resolve after you stop taking the medication:

    Hormone therapy and memory

    Let us know if this is helpful!

    Best,

    The Mods

  • dojtaylor11
    dojtaylor11 Member Posts: 1
    edited December 2015

    i've onlly been taking this for a week and ai feel lik ei have Alzheimers. I was wondering if it' just me or if, in addition to my metastisized breast cancer in my lung, I also have Alzheimer's, which is what my Mothe passed wihth in 1012. i've always been an ectremel functional multitasker,all of a sudden i can't keep up wiht anything, leave my things behin when I leave a place, phone, purse, etc.. and can't analyze anything. this is so frustrating. i waswondering if it's the drug or if tha cance has also metastsized into my brain.. So frustrated


  • gypsyjo
    gypsyjo Member Posts: 304
    edited December 2015

    dojtaylor, you are not alone in your feelings. Their is an effect to memory for many women. Lack of estrogen does have an impact on the brain. The extent varies. I did take some time to try to sort out the cause. Some of it for me was caused by lack of sleep and depression following treatments. I still notice a difference, but it has gotten a little better over time. I even was at a point where when driving I couldn't recognize where I was while driving a route that I had driven for years. Give it some time and track some of your other side effects to see if they are contributing.

  • Brutersmom
    Brutersmom Member Posts: 563
    edited December 2015

    My MO gave me a paper that said memory loss comes from a variety of different reasons including the stress of Cancer, radiation treatment, long term side effect from chemo therapy. the hormone drugs etc. Don't beat yourselves up to much. Each of us has been through a lot emotionally and physically. Seek help if necessary. Sometimes it is just frustrating I try to go with it but it is frustrating.

  • kygirl08
    kygirl08 Member Posts: 1
    edited February 2016

    hello! I know it's been a while since anyone has responded on this post. But my mom has been on arimidex for almost 5 years and had recently stopped taking it. She too has memory loss and "can't get her words out" she has trouble thinking of the words she wants to say and gets tounge tied when she tries to talk. She never had this problem before she started the medicine. I guess my question is people that have experienced these symptoms do they go away when you stop taking the medicine and if so how long before it starts to get better? Thank yo

  • Moderators
    Moderators Member Posts: 25,912
    edited February 2016

    Hi Kygirl-

    We posted some links up thread that seem to suggest cognitive function does improve after stopping the medication. We'll repost them here for you to share with your mom! But it's also a good idea to touch base with her doctors and let them know some of these issues she's having.

    Hormone Therapy and Memory

    Memory Loss

    Hope this is helpful!

    The Mods

  • Af17
    Af17 Member Posts: 1
    edited April 2017

    My mom's oncologist suggested she discontinue taking Arimidex after nearly 8 years because of worsening memory issues. She's only 63. She's been off the medication nearly two months and we haven't noticed much improvement. The posted articles don't have much detail, so I'm hoping to hear from others if they experienced improvement and when.

  • Moderators
    Moderators Member Posts: 25,912
    edited April 2017

    Hi Af17,

    We just wanted to take a moment to welcome you to Breastcancer.org and thank you for posting. Hopefully you'll get some helpful responses soon from others who have experienced improvement.

    We look forward to hearing more from you soon! Please let us know if you need any help while you navigate the boards.

    --The Mods

  • muska
    muska Member Posts: 1,195
    edited April 2017
    Hi Af17, I am very sorry to hear about your Mom's memory issues. Has she been evaluated by a neurologist?

  • Fearless59
    Fearless59 Member Posts: 74
    edited May 2017

    I have been on Arimidex for one week and already noticed a memory problem. Was filling out a job application, and planned to use a friend as a reference, and could not remember her name. My mind went blank. It took about half a minute or possibly a whole minute for the information to come in. I need to work, to pay down my debts and I am little concerned that this could affect how quickly I can learn a job and be good at it. I do admin work, and really rely on my quick mind for problem solving, so I must consider whether I should be maybe cutting back on the drug. Or pretend I'm taking it, and take only half doses, etc., so the doctors will not worry about it and make a fuss. Hmmm.

    I doubt the loss will be permanent. Maybe I can do a week on and a week off. ? Maybe there is a tradeoff. Thanks, everyone, for sharing here.

  • dtad
    dtad Member Posts: 2,323
    edited May 2017

    Fearless...so sorry you are having memory issues on Arimidex. Your comment about pretending to take it or taking less really struck a chord with me. How many other people pretend they are taking it or are taking less? IMO it's so sad that we feel we have to do this. Again I'm happy for those of you who do well on anti hormone therapy. However there are just too many of us that don't. What other option are there? What can we do to increase compliance on these drugs? We should not have to decide between QOL and recurrence. WE need to speak up for better treatment options! Good luck to all navigating this complicated disease.

  • Whitltjr
    Whitltjr Member Posts: 1
    edited May 2017

    Are you still having this problem...it is frighteni

    ng me.

  • mayday66
    mayday66 Member Posts: 1
    edited October 2017

    Oh ladies, how glad I am to hear that I'm not alone! I seriously have had horrible problems with my memory, and did not even connect it with my Arimidex use until recently. I've been on it for a year. My short term memory is totally unreliable. I can recall conversations but not who I had them with, and wake up in a panic thinking I've forgotten to do something at the office, only to get there the next day and realize that I did it. I'm 50 and too young for this! I am going to discuss it with my oncologist next month at my checkup. I want to be protected against recurrence, but is there anything out there with fewer side effects?


  • dtad
    dtad Member Posts: 2,323
    edited October 2017

    mayday66...so sorry you are suffering from memory loss. You are right. You are too young for this but unfortunately it is a SE from the drug. Our brains need estrogen! Maybe you could try a different aromatase inhibitor. Some say changing does make a difference. Good luck and keep us posted.

  • cwayman650
    cwayman650 Member Posts: 102
    edited November 2017

    Arimidex was the first thing I was put on. It was terrible for my memory and gave me terrible joint pain. I felt like an old lady both in movement and mind. I was 52 at the time. (3 yrs ago). The oncologist changed it to Aromasin, then Femara. Those weren't as bad for my memory or joint pain but still had considerable pain. Now I'm on Tomaxifen and doing well on it. Definitely talk to your oncologist. There are other options for you. Tomoxifin isn't a choice for everyone if your still having periods, but the Dr. will discuss that with you. Good luck.

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