Study Prompts Revision in Bone-loss-prevention Guidelines

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cp418
cp418 Member Posts: 7,079

https://breastcancer-news.com/2017/04/27/study-on-...


Breast Cancer and Fractures Study Prompts Revision in Bone-loss-prevention Guidelines

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  • wallycat
    wallycat Member Posts: 3,227
    edited April 2017

    More treatment, more stuff goes wrong. Hate it.

    The jaw issues weren't mentioned in any of it...and many post meno gals will have gum issues because of lack of estrogen.

  • Heidihill
    Heidihill Member Posts: 5,476
    edited May 2017

    There is a mistake in the linked article with reference to denosumab and zoledronate as it differs from the original press release and study. Zoledronate is for when disease recurrence is a priority, denosumab for fracture risks.

    https://eurekalert.org/pub_releases/2017-04/iof-ngf042517.php

    I thought the guideline below was interesting from a mets viewpoint. As in: if they recommend this for all postmeno early stagers with ER+ , then every ER+ postmeno metser on AIs might benefit from it as well, even without bone mets. At least in theory.

    Because of the decreased incidence of bone recurrence and breast cancer specific mortality associated with bisphosphonate use, adjuvant bisphosphonates are recommended for all postmenopausal women at significant risk of disease recurrence.

    For me 5 years of bisphosphonates was well worth it. I had a blood test for bone turnover each time I needed an invasive dental procedure. I gained bone density with the combination of bisphosphonates and lifting weights.

  • Falconer
    Falconer Member Posts: 1,192
    edited May 2017
    Thanks, Heidihill.
  • testus
    testus Member Posts: 2
    edited May 2017
  • Eian01
    Eian01 Member Posts: 30
    edited May 2017

    The more it involves processes the higher risks will be fractures

  • peggy_j
    peggy_j Member Posts: 1,700
    edited May 2017

    Heidihill, can you tell me more about that blood test that checked bone turnover. I've never heard of this. What are they checking? We've been monitoring my bone density every two years but I'm wondering if I should be getting this blood test to see what is going on. Thanks

  • Heidihill
    Heidihill Member Posts: 5,476
    edited May 2017

    From Wikipedia:

    In the early 2000s, a link between bisphosphonate use and impaired bone physiology was noted.[3][4] The strong inhibition of osteoclast function precipitated by bisphosphonate therapy can lead to inhibition of normal bone turnover, leading to impaired wound healing following trauma (such as dental surgery) or even spontaneous non-healing bone exposure. Because bisphosphonates are preferentially deposited in bone with high turnover rates, it is possible that the levels of bisphosphonate within the jaw bones are selectively elevated
    With the advent of implant dentistry, more dental patients are undergoing therapies in the oral cavity that involve bone healing, such as surgical implant placement and bone grafting procedures. In order to evaluate the risk of osteonecrosis for a patient taking bisphosphonates, use of the CTX biomarker was introduced in 2000 by Rosen.

    ----

    I don't know if it is still being used as it has been some time since I was getting Zometa infusions.

  • peggy_j
    peggy_j Member Posts: 1,700
    edited May 2017

    Great, thanks for posing. I emailed my endocrinologist and he said that he wants to hold off on ordering any tests until we meet and review my DEXA images. BTW, he said bone marker tests can be $$ and some insurance plans don't cover the cost. Was that your experience?

  • Heidihill
    Heidihill Member Posts: 5,476
    edited May 2017

    insurance covered it for me. But I am not in the US where medical costs tend to be higher.

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