Concurrent ER/PR +, HER2 - and an ER/PR +, HER + tumors

Anyone else experience both HER2 - and HER2+ tumors at the same time? It certainly seems like it could complicate or confuse things, treatment or prognosis wise, from what I have read. Sigh.

I haven't seen my oncologist yet. They still did an Oncotype DX test, even though I had one tumor that was HER2 + and that should be back this week.

I had small tumors (the largest was the HER2 + at only 6mm and 3 others under 4mm - all of those were invasive - 3 ductal and one lobular - and then a couple of areas of DCIS). I had bilateral mastectomies (DIEP flap reconstruction - 4 weeks ago). I also have negative nodes (stray tumor cells, but under 200, so they consider that negative). I go to Mayo Jacksonville and they tend to be kindness of conservative - radiation was never really on the table. Now, I don't know what to expect chemo wise. If I was HER2 - completely, I think I could have gotten away with not doing chemo, but with HER2+, I'll need Herceptin, which is only FDA approved in conjunction with chemo (and the stats are for mostly for that).

Also, I have genetic mutation that would make Tamoxifen not metabolize properly and I've read HER2 positive tumors can make you Tamoxifen resistant anyway. I am considering a hysterectomy, so I can take the aromatase inhibitors. I don't want to mess around. I am only 42 and have a 12 and 10 year old.

Any thoughts? Questions I should ask the oncologist? Any studies I could look at? I knew people could be HER2 - and the be HER2+, I just never knew it could occur at the same time. It's just like me to be complicated 😉. My husband calls me the 1% because if someone gets something, it's me (I already deal with a host of autoimmune issues and disorders that often go along with them - I am concerned that may also affect my treatment or that the treatment may triggers new autoimmune disease).

Sorry for the book. If anyone followed my rambling, feel free to comment.

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