Arimidex & Cartlidge/Tendon/Joint Degeneration

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  I was told by a doctor that Arimidex causes the cartlidge and tendons in our joints to dry, become brittle, and therefore we who are on this medication, are more prone to cartlidge and ligament tears and injuries. Have any of you heard mention of this?

Comments

  • karen1956
    karen1956 Member Posts: 6,503
    edited June 2010

    I developed CTS on Arimidex and dequervances tendonities on Aromasin....CTS is listed as a side effect of Arimidex

  • delfratte1
    delfratte1 Member Posts: 1
    edited June 2010

    I have been on arimidex for ten months.  I found a 2 1/2 inch lump in my left breast and was diagnosed with stage III breast cancer.  I had a mastectomy, followed by 4 months of chemo and five weeks of radiation.During chemo, I found lumps in my right breast which were benign.  I decided to have another mestectomy.  Lately my joint/bone pain is so severe I need to take hydrocodone to function.  When I awake, I can hardly get out of bed.  My fingers would not bend and I was tested for carpal tunnel syndrome.  The test showed bilateral carpal tunnel.  I hesitate to have surgery, since I believe much of my pain can be attributed to arimidex.  Yesterday my oncologist agreed to allow me to go off arimidex for three weeks, to see if I feel better.

    The bone and joint pain depresses me and keeps me from doing all the things I love to do, like gardening and playing with my grandchildren.

    Is anyone else having trouble with arimidex?  Also, what is CTS.  Is it carpal tunnel syndrome?

  • Katiejane
    Katiejane Member Posts: 789
    edited June 2010

    delfratte,  I have been on Arimidex for just alittle over 2.5 years with another 2.5 years to go. I do experience joint pain time to time but it does seem to come and go.I don't know what I would do if it was a constant! I also Have CTS-yes, that is the abbreviation for carpal tunnel. Mine started when I was pregnant w/ my 1st child 24 years ago. It then kind of disappeared. If I would do alot with my hands on any given day it would aggravate it once again.Since my children have left the nest I've gone back to work full time and it has reared it's ugly head once more. So this past April 19th I had CT release surgery on my L hand. Results have been great so far-no numbness, tingling, or pain. I don't know if I'll ever do the R hand as I have lymphedema in that arm. I really can't say what caused my CTS to reappear but I don't think it was the Arimidex. Even if it was the cause I wouldn't stop the Arimidex. I can live w/ CTS---I can't live with cancer. Good luck and I hope this resolves itself!  Katiejane

  • Wendy66
    Wendy66 Member Posts: 3
    edited June 2010

    Wow!  I have been on Arimidex for only 3 weeks and I feel like crap!  I feel dizzy all the time, nausea all the time, I hurt all over, especially my hands, wrist, one arm, neck, back.  I have no energy and my sex drive is gone!!  I was diagnosed in Feb. 2007 with stage 2 breast cancer.  I had a lumpectomy and 7 Lymphnodes removed.  I had Chemo. Then Radiation and then a year of Herceptin. Then I was put on Tamoxifen and I had a Hysterectomy and I was just put on Arimidex.  I am tired just wondering if anyone else feels this way!!!

  • EWB
    EWB Member Posts: 2,927
    edited June 2010

    I have not heard that but I have certainly experienced this on Femara...I have been on for 3.5 yrs and in addition to the general stiffness...have have joint pain almost daily and def notice I am more prone to tendonitis-ish problems. No help from ortho who just says I am getting older..ack. getting older does not normally happen over night.

  • ruthbru
    ruthbru Member Posts: 57,235
    edited June 2010

    I think that exercise is the 'magic bullet' to keep everything working like it should, that and the calcium/vitamin D component.

  • webstertoo
    webstertoo Member Posts: 51
    edited June 2010

    Dear Delfratte,

    I gave arimidex gave six months and am now on tamoxifen for the last two and feeling so much better. I had trouble excercising as it was painful to walk. Now I'm back at the gym and my hands, while not yet back to pre-arimidex are much better.  Give it a little longer but there are alternatives.

  • PB22
    PB22 Member Posts: 315
    edited June 2010

    I had the same complaints after taking arimidex for 6weeks, the difficulty opening and closing fingers, getting up from sitting position, stiffness.  After my revision of the implants I took tramadol for pain and realized I did not have the arthritic pain any more.  I am now off the tramadol and the arthritic pain is mild.  I only took the tramadol once a day and not the twice prescribed and when I thought about it, I realized it cured my complaints with the arimidex.  I did not have any of the side effects mentioned on the tramadol insert.

  • MonicaSmith
    MonicaSmith Member Posts: 18
    edited June 2010

    I have 18 months to go on Arimidex and have had constant problems.  I had CPS in 2007, the year after my mastectomy.   CPS was a recurrence from 2003.  The shots worked until the mastectomy when I began to sleep on my right side.  Now I have knee problems following a sport injury "keeping fit".  I am at my wits end.  I am terrified to go off the drug as this was my second bout with breast cancer.  After a lumpectomy in 1998 I refused Tamoxifen as I thought the risk very small.  Currently it is Motrin and Ambien that keeps me going but  this makes me bitchy and easily irritated.   It seems that as soon as one problem is fixed another arises.  I hate that all the time I am complaining it is now getting to my husband

  • KinAZ
    KinAZ Member Posts: 180
    edited June 2010

    I have been on arimidex for 17 months....suffer with the hand and general body stiffness and random shooting pains (mostly in the feet) and have developed trigger finger.  My hip joints hurt when I walk, and it is painful to stand up and sit down....Called the onco last month, took a 2 wk vacation and then started on aromisin....only difference was the hip pain was gone...but, developed upset stomach and the runs....called onco back after 3 wks...was told we could try femara, but it is similar to arimidex....so taking another 2 wk vacation and then back to the arimidex.

    I spoke with my primary dr, and he explained that the cartilage does not repair itself...so once the damage is done...its done....i have avoided pain pills, take motrin, and exercise doesnt make any difference....i know its important to keep the estrogen down, but some days are very hard

    my family has become immune to my complaining and difficulty moving.  i think that is a normal reaction....it is just the new normal.....praying the find a cure....soon

    Karen

  • JaniceM
    JaniceM Member Posts: 1
    edited June 2010
    I had BC in Oct of 2006.  After chemo, I had three years of Tamoxifen.  I was also on Lexapro, 20 mg daily.  This March I started Arimidex.  I was down to 10 mg of Lexapro, but was weaning completely off.  I didn't have any pains or symptoms (other than hot flashes) on Arimidex.  A month after being on it, I was completely off the Lexapro.  Then what a Mess!!!!  I had devastating pains in my larger joints; hot and cold flashes; shakes and flu-like symptoms; on and on.  After a month of symptoms, I went back to my oncologist.  I actually broke down in his office.  I was shivering in 80 degree weather with a sweater on.  He told me to get back on the Lexapro immediately.  Within two days of taking the Lexapro again, ALL my symptoms disappeared (of course, not the Hot flashes).  I have never had a recurrence of those symptoms of Arimidex, not one complaint.  I don't know whether it's coincidence, but it sure doesn't sound like it.  If you're a mess, ask your doc about Lexapro.  I've read some of the posts and complaints on this subject, and can only say that off the Lexapro = Yell; on Lexapro = Laughing
  • Hummingbirdnomore
    Hummingbirdnomore Member Posts: 2
    edited March 2017

    I have been experiencing a great deal of pain in my feet and hands. I finished chemo in Nov 2013 and was put on Tamoxifen. Then I started bleeding so much that I decided to have a hysterectomy. After that I was switched to Arimidex. The hot flashes were hard enough to put up with but then my feet started to ache. When I got up out of bed I felt like my feet had been crushed. Then my joints in my hands began to ache. I felt that I was too young for arthritis but that is what I was diagnosed with. My index and middle fingers have knots on them now. My oncologist switched me to Femara. I had a work injury and learned I had a torn tendon & ligament in my thumb. I had physical therapy and that thumb felt better, but soon after I had another work injury which tore the ligament in my other thumb. Still complaining of joint pain and about 1 month on Femara she took me off all medication. I soak my hands in paraffin baths and wear splints to no avail. I have orthotics in my shoes and still I hurt. After speaking with another cancer survivor I learned that radiation, chemo and medication affects the tendons and ligaments of the body. I looked online and saw all of these posts of people suffering from the same symptoms as me. My orthopedist said he wasn't sure if my ligaments were previously weakened prior to my work injury and he is suggesting I have my thumb joints fused. I work with my hands all of the time and was always in motion. No I have to stop doing so much to keep my hands & feet from being in so much pain. On top of all of this my elbow tendons have joined the party. I'm seeing a new oncologist next week and will ask about all of these issues, but I feel certain all of the medication has made me feel like I'm quickly deteriorating! I've been in remission for almost 3 years and I'm grateful but I will not take anymore medication

  • Hummingbirdnomore
    Hummingbirdnomore Member Posts: 2
    edited March 2017
  • Kayla250
    Kayla250 Member Posts: 201
    edited March 2017

    sorry to hear you're having such problems. I was put on letrozole to begin with I couldn't stand those side effects after a few months. I was put on Anastrozole and still had excruciating pains. My PCP sent me to a Rheumatologist and it turned out I had rheumatoid arthritis. I was put on pills for that and I'm much better now. However, I did fracture a hip, running a half marathon in Germany in June, but my bone density came out fine, we can't rule out that it would have happened on or off AI's. Try to hang in there,though, I think Anastrozole may have saved my life.

    In Canada CPS, is a pharmaceutical commission...

  • jpteacher1
    jpteacher1 Member Posts: 52
    edited March 2017

    I was put on Arimidex in 2013. Before Arimidex, I had a little osteoarthritis in my knees, but was walking without assistance and no major pain. Four years later, I have severe inflammatory arthritis, rheumatoid arthritis and osteopenia. I use a walker most of the time an an Amigo when I shop. Rheumatologist said enough was enough of Arimidex. I just stopped Arimidex and hope it isn't too late! My friends have watched my decline and can't believe what has happened to me.

    I know everyone is different. I pray that 4 years of Arimidex had prevented a reoccurrence but at what cost

  • Kayla250
    Kayla250 Member Posts: 201
    edited March 2017

    jpteacher1 - really!? They are saying it was the Anastrozole? Wow, I'm three years off chemo, 2 years on Anastrozole. I have rheumatoid arthritis, fractured a hip and am now, March 2nd, diagnosed with recurrence. Having double mastectomy and who knows what else after that?

    Yes, Anastrozole, to what end?

  • ChiSandy
    ChiSandy Member Posts: 12,133
    edited March 2017

    Cartilage degeneration & joint pain are the most common SE’s of any AI, not just anastrozole. It’s a logical result of estrogen deprivation. I don’t get it in my knees because they don’t have cartilage—they have prostheses (brutal rehab but best elective surgical decision I ever made). As for joint pain everywhere else, I take a couple of 8-hr. Tylenol at bedtime and 200mg. of celecoxib (generic Celebrex) on arising. I was diagnosed with osteopenia before starting letrozole; had one Zometa infusion (never again!), am having a Prolia injection next week (so 2 treatments down, 2 to go), and my next DexaScan is in Nov.—it’ll reveal how much (if any) damage the AI did and how well the bone drugs worked.

  • Bcky
    Bcky Member Posts: 167
    edited May 2017

    I have been on Tamoxifen for 2 years. The bone scans say my bones are getting stronger. Much to my surprise I found out Monday I need a total knee replacement. The cartlidge was wearing thin last year and is completely gone now.I feel I have a 60 yr olds body.

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