KI-67 and Oncotype Scores - comparison

My oncotype was 9 and I never got a KI 67 scor

My oncotype was 3, KI-67 22%. Three different doctors told me oncotype trumps grade. My onc has very little faith in the ki-67, which btw is part of the oncotype score.

Here is a link to some interesting info re: oncotype.

http://www.stjames.ie/GPsHealthcareProfessionals/C...

Keep in mind that the Ki Score is an eyeball test and studies have proven it unreliable to use for grade 2 tumors. Grade 1 and 3 show more reliablity. For example, one major study sent the same samples to different top pathologist and no two pathologist could agree on a Ki score. One specimen had several say it was a 5% and others say it was 35%. My oncologist completely disregarded my 'high' ki score and the mammaprint proved I was low risk.

However, we found very high inter-observer variabilities (Kappa 0.04-0.14) in the read-outs of the G2 carcinomas. It was not possible to explain the inconsistencies exclusively by any of the following factors: (i) pathologists' divergent definitions of what counts as a positive nucleus (ii) the mode of assessment (counting vs. eyeballing), (iii) immunostaining technique, and (iv) the selection of the tumor area in which to count. Despite intensive confrontation of all participating pathologists with the problem, inter-observer agreement did not improve when the same slides were re-examined 4 months later (Kappa 0.01-0.04) and intra-observer agreement was likewise poor (Kappa 0.00-0.35). Assessment of mid-range Ki-67-LI suffers from high inter- and intra-observer variability. Oncologists should be aware of this caveat when using Ki-67-LI as a basis for treatment decisions in moderately differentiated breast carcinomas.
https://www.researchgate.net/publication/225098187_How_Reliable_Is_Ki-67_Immunohistochemistry_in_Grade_2_Breast_Carcinomas_A_QA_Study_of_the_Swiss_Working_Group_of_Breast-_and_Gynecopathologists

My oncotype was 25 and my K167 was 40%. Lumpectomy was almost 8 weeks ago and my two MOs, first and second opinions, now have divergent opinions. One says no chemo, just radiation and hormonal therapy and the other wants to talk to me tomorrow and seems to be heading me in the direction of starting with chemo first. It is all so confusing and a bit subjective, but I want treatment started already so I can move on to fight this BC. I feel like I don't have the time to wait for more tests/doctors. The Tailorx study would seem to say I don't need chemo as I'm over 50 with a score of 25, but of course I'm on the cusp and with a high k167 score, maybe that changes things. Just too much to absorb. Thoughts??

my ki-67 was unknown my oncodx was 34.

There was no ki-67 score on either my pathology or oncodx report.

I’m assuming you got chemotherapy then regardless of your age, correct

my ki67 was 9%. My oncotype was 15. Im 43. No chemo. My stats are in my signature.

My oncotype was 20 and my Ki was 35%... HOWEVER, as I keep saying ladies.  It's an eyeball test.  Every pathologist sees it differently and if you are grade 2, ki is TOTALLY unreliable as studies show that what is 5% to one pathologist is 35% to another.  Please read my comments earlier on the disparity in evalutating ki.

NO CHEMO for me. I was low risk. 

This is an old thread, but I was very glad to stumble upon it. I had DCIS 6 mm, with an invasive component of 3 mm. ER 98%, PR 40% Her 2 negative at 0%. Stage 1A. What scares me is the KI-67 came back at 37%. Oncologist assures me that this is nothing to worry about........She says it's almost certainly luminal A, weird because the mitotic rate was a 1. When I asked her about that, she just shrugged her shoulders. I had a grade 2 score. Lump/rads/ letrozole. I'm mostly ok, but the Ki-67# is high. Not much I can do about it. I wish I had not ever seen that number, it was on the path report. Only a 3mm tumor, so no Oncotype score, that worries me as well. She said they don't test tumors that small, as chemo would not have been indicated at any rate. Hope she's right.

Oncotype 16, KI67 40%

I can no longer find my Ki67 but the number 33% is in my head. I can't find it on the Oncotype, it was 17. I'm a grade 2, luminal A also. I believe it was tumor size that upped my stage from a 1 to a 2? Or was it the micromet? The staging changed right after my diagnosis. You ladies are so good at understanding this, because I still do not totally get all the different things they test/check. I just hope it stays gone for the rest of my life!

This pandemic is stressing me on all levels. I want to be able to shop AT the store but too scared. Plus immune suppressed and 4 kids that are tired of being in the house.

Yes, chemo started this morning. They infuse really slow so I don't have a reaction. Started at 9:30. Its now 2:30. But no reaction so thats good.

Have you had genetic testing? Got my results back today and I have an ATM gene mutation. This puts me at high risk for breast and pancreatic cancer. Maybe you should ask your dr about that. If it came back clear it might ease your worry!

oncotype 4, Ki-67 was 21%. None of the oncologist put much stock in the Ki-67 score

Related, does anyone know how the Quantitative Single-Gene Scores at the bottom of the oncotype DX report are relevant to treatment recommendations?